CRCGN014_HEPG2_3H:N02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diisononyl phthalate 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

322 genes differentially expressed following the CRCGN014_HEPG2_3H:N02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 7.47342
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.77626
MAP7 microtubule-associated protein 7 5.55615
CIAO3 cytosolic iron-sulfur assembly component 3 4.6938
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.58062
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 4.56513
SHB Src homology 2 domain containing adaptor protein B 4.04206
TRIM13 tripartite motif containing 13 3.93186
DENND2D DENN/MADD domain containing 2D 3.9036
TIAM1 T-cell lymphoma invasion and metastasis 1 3.85431
JADE2 jade family PHD finger 2 3.84543
HPRT1 hypoxanthine phosphoribosyltransferase 1 3.83074
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.82331
CAPN1 calpain 1, (mu/I) large subunit 3.48954
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.39416
IDE insulin-degrading enzyme 3.1446
VGLL4 vestigial-like family member 4 3.13295
LOXL1 lysyl oxidase-like 1 3.13013
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.10269
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.06422
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.03158
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.02593
CCNF cyclin F 3.00542
PRDM5 PR domain containing 5 2.94693
DAO D-amino-acid oxidase 2.91986
TERT telomerase reverse transcriptase 2.87509
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.8513
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.81645
STK10 serine/threonine kinase 10 2.80718
ASCL3 achaete-scute family bHLH transcription factor 3 2.77136
TGFB3 transforming growth factor, beta 3 2.74628
USP29 ubiquitin specific peptidase 29 2.66887
CLDN4 claudin 4 2.66865
BCL2L14 BCL2-like 14 (apoptosis facilitator) 2.6532
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.64705
NPY4R2 neuropeptide Y receptor Y4-2 2.62116
PMM2 phosphomannomutase 2 2.61967
OR10H3 olfactory receptor, family 10, subfamily H, member 3 2.61365
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.6099
IL22 interleukin 22 2.5875
CDK19 cyclin-dependent kinase 19 2.5828
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 2.58265
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.57694
NCKIPSD NCK interacting protein with SH3 domain 2.56884
CLEC1A C-type lectin domain family 1, member A 2.56678
ADAM29 ADAM metallopeptidase domain 29 2.56239
OR10J1 olfactory receptor, family 10, subfamily J, member 1 2.54551
MAST2 microtubule associated serine/threonine kinase 2 2.54392
SQOR sulfide quinone oxidoreductase 2.54058
CBR3 carbonyl reductase 3 2.5333
GCGR glucagon receptor 2.52943
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.52556
OR1G1 olfactory receptor, family 1, subfamily G, member 1 2.52003
FBXO34 F-box protein 34 2.50831
PMFBP1 polyamine modulated factor 1 binding protein 1 2.50553
UBQLN2 ubiquilin 2 2.49478
MROH7 maestro heat-like repeat family member 7 2.49034
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 2.48795
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.47485
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.47435
FSCN3 fascin actin-bundling protein 3, testicular 2.47373
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.47232
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 2.46921
CXCL2 chemokine (C-X-C motif) ligand 2 2.46843
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.46644
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.44933
NPVF neuropeptide VF precursor 2.43318
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.43263
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 2.43127
TAAR5 trace amine associated receptor 5 2.42657
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.41786
OR1E1 olfactory receptor, family 1, subfamily E, member 1 2.41007
NPBWR2 neuropeptides B/W receptor 2 2.40511
ILK integrin-linked kinase 2.40439
SMCP sperm mitochondria-associated cysteine-rich protein 2.39446
PLSCR2 phospholipid scramblase 2 2.39236
UNC5C unc-5 homolog C (C. elegans) 2.38838
RFPL3 ret finger protein-like 3 2.38751
NMBR neuromedin B receptor 2.38572
MMP2 matrix metallopeptidase 2 2.38272
TMC7 transmembrane channel-like 7 2.37524
ZBTB18 zinc finger and BTB domain containing 18 2.37365
CHRM2 cholinergic receptor, muscarinic 2 2.36993
CDON cell adhesion associated, oncogene regulated 2.35733
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.35721
CFHR5 complement factor H-related 5 2.351
FSHR follicle stimulating hormone receptor 2.34898
ZNF589 zinc finger protein 589 2.34227
OVOL1 ovo-like zinc finger 1 2.34214
DAGLA diacylglycerol lipase, alpha 2.34016
THRB thyroid hormone receptor, beta 2.33657
MAGIX MAGI family member, X-linked 2.32992
SPATA31A3 SPATA31 subfamily A, member 3 2.32659
TULP2 tubby like protein 2 2.32627
HCRTR1 hypocretin (orexin) receptor 1 2.3202
EFR3B EFR3 homolog B (S. cerevisiae) 2.30953
CBR1 carbonyl reductase 1 2.30899
XCR1 chemokine (C motif) receptor 1 2.30861
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 2.3079
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 2.30666
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 2.29764
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.2914
ZPBP zona pellucida binding protein 2.28832
SYNGR4 synaptogyrin 4 2.28786
FBP1 fructose-1,6-bisphosphatase 1 2.28779
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.28648
NSUN7 NOP2/Sun domain family, member 7 2.27893
SYK spleen tyrosine kinase 2.27406
SGPP2 sphingosine-1-phosphate phosphatase 2 2.27355
ADAM30 ADAM metallopeptidase domain 30 2.27341
OR2F2 olfactory receptor, family 2, subfamily F, member 2 2.27323
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 2.27135
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.26991
TSSK2 testis-specific serine kinase 2 2.26755
AKAP1 A kinase (PRKA) anchor protein 1 2.26703
OR2H1 olfactory receptor, family 2, subfamily H, member 1 2.26416
TAS2R3 taste receptor, type 2, member 3 2.25493
HOXB8 homeobox B8 2.25416
CYSLTR1 cysteinyl leukotriene receptor 1 2.25126
OR12D3 olfactory receptor, family 12, subfamily D, member 3 2.25012
ODAD2 outer dynein arm docking complex subunit 2 2.24913
SFTPB surfactant protein B 2.24839
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.24482
GPR173 G protein-coupled receptor 173 2.23783
OR5I1 olfactory receptor, family 5, subfamily I, member 1 2.23417
SP4 Sp4 transcription factor 2.23114
CCDC7 coiled-coil domain containing 7 2.23047
OR10H2 olfactory receptor, family 10, subfamily H, member 2 2.22744
SYT13 synaptotagmin XIII 2.22713
DIAPH3 diaphanous-related formin 3 2.22118
PDZD7 PDZ domain containing 7 2.21794
IFNA7 interferon, alpha 7 2.21689
RDH16 retinol dehydrogenase 16 (all-trans) 2.21521
UBQLN3 ubiquilin 3 2.21344
STAP2 signal transducing adaptor family member 2 2.21312
GPR3 G protein-coupled receptor 3 2.21203
PRODH2 proline dehydrogenase (oxidase) 2 2.20928
AANAT aralkylamine N-acetyltransferase 2.20918
MEN1 multiple endocrine neoplasia I 2.20734
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 2.20376
MLNR motilin receptor 2.19957
ACR acrosin 2.1983
ODF1 outer dense fiber of sperm tails 1 2.19616
FETUB fetuin B 2.19236
C5 complement component 5 2.19209
OR1D2 olfactory receptor, family 1, subfamily D, member 2 2.19063
SCN10A sodium channel, voltage gated, type X alpha subunit 2.18637
FAM135A family with sequence similarity 135, member A 2.18629
SHCBP1L SHC SH2-domain binding protein 1-like 2.18504
CNGA1 cyclic nucleotide gated channel alpha 1 2.18261
TSBP1 testis expressed basic protein 1 2.18233
OVOL3 ovo-like zinc finger 3 2.1791
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa 2.17881
ACRV1 acrosomal vesicle protein 1 2.17715
CIBAR1 CBY1 interacting BAR domain containing 1 2.16775
CHN1 chimerin 1 2.16756
GRPR gastrin-releasing peptide receptor 2.16369
ZNF507 zinc finger protein 507 2.16019
COQ8A coenzyme Q8A 2.15694
ZNF154 zinc finger protein 154 2.1559
OR7A10 olfactory receptor, family 7, subfamily A, member 10 2.15478
MYH4 myosin, heavy chain 4, skeletal muscle 2.15422
ADAM21 ADAM metallopeptidase domain 21 2.14988
GALR3 galanin receptor 3 2.14622
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.1457
SSTR4 somatostatin receptor 4 2.14559
MAP3K3 mitogen-activated protein kinase kinase kinase 3 2.14421
EPB41 erythrocyte membrane protein band 4.1 2.1437
ABHD18 abhydrolase domain containing 18 2.14271
TAS2R13 taste receptor, type 2, member 13 2.14135
PDE7B phosphodiesterase 7B 2.13743
UPK1A uroplakin 1A 2.13595
PITPNM3 PITPNM family member 3 2.13254
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.13122
RRH retinal pigment epithelium-derived rhodopsin homolog 2.12858
GPR132 G protein-coupled receptor 132 2.1246
RFX3 regulatory factor X, 3 (influences HLA class II expression) 2.12354
BTC betacellulin 2.11838
CRHR2 corticotropin releasing hormone receptor 2 2.11698
IFNW1 interferon, omega 1 2.116
FRAS1 Fraser extracellular matrix complex subunit 1 2.11201
FSTL4 follistatin-like 4 2.10914
ALDOC aldolase C, fructose-bisphosphate 2.10906
OR1A2 olfactory receptor, family 1, subfamily A, member 2 2.10661
PRAMEF10 PRAME family member 10 2.10541
ZFY zinc finger protein, Y-linked 2.10238
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.10112
IFNA10 interferon, alpha 10 2.10011
BTG4 B-cell translocation gene 4 2.09378
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 2.0868
ZXDB zinc finger, X-linked, duplicated B 2.08578
TMOD3 tropomodulin 3 (ubiquitous) 2.08356
BSPRY B-box and SPRY domain containing 2.08159
CASS4 Cas scaffolding protein family member 4 2.07989
POPDC2 popeye domain containing 2 2.07986
ACTL7A actin-like 7A 2.07721
AVPR1A arginine vasopressin receptor 1A 2.07703
SLC25A30 solute carrier family 25, member 30 2.07625
KRT37 keratin 37, type I 2.07548
IFNA21 interferon, alpha 21 2.075
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 2.07468
ASCL2 achaete-scute family bHLH transcription factor 2 2.07288
CUEDC1 CUE domain containing 1 2.06952
CCR6 chemokine (C-C motif) receptor 6 2.06771
CAPN11 calpain 11 2.06733
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 2.06298
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 2.061
RARG retinoic acid receptor, gamma 2.06098
GIMAP5 GTPase, IMAP family member 5 2.05916
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) 2.05369
IMPG1 interphotoreceptor matrix proteoglycan 1 2.05322
ZNF81 zinc finger protein 81 2.05304
OR2J3 olfactory receptor, family 2, subfamily J, member 3 2.05299
BTNL2 butyrophilin-like 2 2.05289
S1PR2 sphingosine-1-phosphate receptor 2 2.05219
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.05213
COL4A4 collagen, type IV, alpha 4 2.05079
OXCT2 3-oxoacid CoA transferase 2 2.046
STON1-GTF2A1L STON1-GTF2A1L readthrough 2.04397
RCVRN recoverin 2.04365
ALOXE3 arachidonate lipoxygenase 3 2.04258
KLF3 Kruppel-like factor 3 (basic) 2.04195
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.03823
A4GNT alpha-1,4-N-acetylglucosaminyltransferase 2.03761
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 2.03733
UPK3A uroplakin 3A 2.03717
ELF5 E74-like factor 5 (ets domain transcription factor) 2.03665
AFM afamin 2.03478
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.03395
IFNA5 interferon, alpha 5 2.03078
GRAPL GRB2-related adaptor protein-like 2.03051
TAS2R16 taste receptor, type 2, member 16 2.02941
CLEC4E C-type lectin domain family 4, member E 2.02938
TMLHE trimethyllysine hydroxylase, epsilon 2.0276
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.02741
PLA2G4B phospholipase A2, group IVB (cytosolic) 2.02682
RAB21 RAB21, member RAS oncogene family 2.0254
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.02465
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 2.02462
IL2 interleukin 2 2.02428
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.02144
PAPOLB poly(A) polymerase beta (testis specific) 2.02138
INHBC inhibin, beta C 2.01875
USP53 ubiquitin specific peptidase 53 2.01867
MINDY1 MINDY lysine 48 deubiquitinase 1 2.01852
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.01691
OCLN occludin 2.01505
SPICE1 spindle and centriole associated protein 1 2.01415
SELE selectin E 2.01385
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 2.00813
KCNA10 potassium channel, voltage gated shaker related subfamily A, member 10 2.00657
CDC50B cell division cycle 50 P4-ATPase accessory subunit B 2.00648
GLRA2 glycine receptor, alpha 2 2.00596
GRIK3 glutamate receptor, ionotropic, kainate 3 2.00559
CHRM5 cholinergic receptor, muscarinic 5 2.00462
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.00256
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.00236
FOXN1 forkhead box N1 2.00013

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.17095
PCNA proliferating cell nuclear antigen -7.01514
GRWD1 glutamate-rich WD repeat containing 1 -5.97872
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.99857
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.88079
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.74126
NISCH nischarin -4.63858
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.52878
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -4.38566
ADI1 acireductone dioxygenase 1 -4.26364
ZNF586 zinc finger protein 586 -4.07279
MAPK13 mitogen-activated protein kinase 13 -3.99249
MRPS2 mitochondrial ribosomal protein S2 -3.95481
COG2 component of oligomeric golgi complex 2 -3.89255
CLTB clathrin, light chain B -3.64372
OXA1L oxidase (cytochrome c) assembly 1-like -3.58632
PARP2 poly (ADP-ribose) polymerase 2 -3.50581
NOP56 NOP56 ribonucleoprotein -3.31004
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.2945
DPH2 DPH2 homolog (S. cerevisiae) -3.28308
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.21091
FASTKD5 FAST kinase domains 5 -3.11985
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.01934
SLC35F2 solute carrier family 35, member F2 -2.93583
FGFR4 fibroblast growth factor receptor 4 -2.91971
TSPAN4 tetraspanin 4 -2.71299
PROS1 protein S (alpha) -2.7108
TBC1D31 TBC1 domain family, member 31 -2.67543
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -2.67535
ZMIZ1 zinc finger, MIZ-type containing 1 -2.66472
TCTN1 tectonic family member 1 -2.55546
HMG20B high mobility group 20B -2.53033
EIF5 eukaryotic translation initiation factor 5 -2.51643
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.47223
CHMP6 charged multivesicular body protein 6 -2.4526
RGS2 regulator of G-protein signaling 2 -2.44358
SMNDC1 survival motor neuron domain containing 1 -2.41587
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -2.40662
FOS FBJ murine osteosarcoma viral oncogene homolog -2.34735
HAT1 histone acetyltransferase 1 -2.30931
AACS acetoacetyl-CoA synthetase -2.26109
TLCD3A TLC domain containing 3A -2.24717
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.24495
CDKN2A cyclin-dependent kinase inhibitor 2A -2.22639
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -2.21315
ETFB electron-transfer-flavoprotein, beta polypeptide -2.19574
DOHH deoxyhypusine hydroxylase/monooxygenase -2.18701
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.17926
WDR91 WD repeat domain 91 -2.15694
KLHL21 kelch-like family member 21 -2.14823
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.13146
TFB2M transcription factor B2, mitochondrial -2.12741
WDR7 WD repeat domain 7 -2.11577
SRPRB signal recognition particle receptor, B subunit -2.10904
QRICH1 glutamine-rich 1 -2.0955
CRELD2 cysteine-rich with EGF-like domains 2 -2.09047
CBX6 chromobox homolog 6 -2.07548
ISOC1 isochorismatase domain containing 1 -2.05545
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -2.05396
WRN Werner syndrome, RecQ helicase-like -2.03669
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -2.03528
MCUR1 mitochondrial calcium uniporter regulator 1 -2.03325
WDR12 WD repeat domain 12 -2.01344
RNF44 ring finger protein 44 -2.0098