CRCGN014_HEPG2_3H:N03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dibromoethane 39.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN014_HEPG2_3H:N03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 6.11719
PLS1 plastin 1 5.20546
NFIL3 nuclear factor, interleukin 3 regulated 4.54503
SNAP25 synaptosomal-associated protein, 25kDa 4.15272
PMM2 phosphomannomutase 2 3.99363
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.78143
CHN1 chimerin 1 3.72762
SMIM40 small integral membrane protein 40 3.55494
TREM1 triggering receptor expressed on myeloid cells 1 3.45291
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.34681
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.18631
CHMP6 charged multivesicular body protein 6 3.05383
SFTPB surfactant protein B 3.0132
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.95438
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.87598
KIF20A kinesin family member 20A 2.8325
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.64473
BAMBI BMP and activin membrane-bound inhibitor 2.63118
CYCS cytochrome c, somatic 2.34359
KIF5A kinesin family member 5A 2.31921
GPATCH8 G patch domain containing 8 2.30453
LMO7 LIM domain 7 2.19738
NPDC1 neural proliferation, differentiation and control, 1 2.16796
SNAP91 synaptosomal-associated protein, 91kDa 2.16539
BAG3 BCL2-associated athanogene 3 2.11735
UBE2A ubiquitin-conjugating enzyme E2A 2.11667
EMID1 EMI domain containing 1 2.10109
TIAM1 T-cell lymphoma invasion and metastasis 1 2.02599
LMCD1 LIM and cysteine-rich domains 1 2.01214
GPER1 G protein-coupled estrogen receptor 1 2.00457

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -8.48721
VAT1 vesicle amine transport 1 -5.27064
ZNF586 zinc finger protein 586 -4.8346
PRPF4 pre-mRNA processing factor 4 -4.7703
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.64782
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.37983
PECR peroxisomal trans-2-enoyl-CoA reductase -4.32436
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.30412
HMG20B high mobility group 20B -3.7862
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.21702
DNM1L dynamin 1-like -3.21015
HSPA8 heat shock 70kDa protein 8 -3.07596
SNX11 sorting nexin 11 -3.07023
RFC2 replication factor C (activator 1) 2, 40kDa -2.70303
STX4 syntaxin 4 -2.55389
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.55186
GDF15 growth differentiation factor 15 -2.33785
GNAS GNAS complex locus -2.27819
FRMD4B FERM domain containing 4B -2.15961
MTERF3 mitochondrial transcription termination factor 3 -2.15425
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.13666
ACAA1 acetyl-CoA acyltransferase 1 -2.02419