CRCGN014_HEPG2_3H:N05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chloroform 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN014_HEPG2_3H:N05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 8.21416
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.6427
CHN1 chimerin 1 5.29195
E2F2 E2F transcription factor 2 4.98
CXCL2 chemokine (C-X-C motif) ligand 2 4.40867
UBE2A ubiquitin-conjugating enzyme E2A 4.3737
PMM2 phosphomannomutase 2 4.35836
PRR15L proline rich 15-like 4.12841
ANO1 anoctamin 1, calcium activated chloride channel 3.59401
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.53013
ATP11B ATPase, class VI, type 11B 3.51741
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.4909
SFTPB surfactant protein B 3.47103
HYOU1 hypoxia up-regulated 1 3.19105
PFKL phosphofructokinase, liver 3.02956
SHB Src homology 2 domain containing adaptor protein B 2.72938
KAT6A K(lysine) acetyltransferase 6A 2.69238
FCHO1 FCH domain only 1 2.65187
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.45782
CCNF cyclin F 2.43595
JCAD junctional cadherin 5 associated 2.42453
KIF14 kinesin family member 14 2.32563
GPER1 G protein-coupled estrogen receptor 1 2.31122
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.2556
REG1B regenerating islet-derived 1 beta 2.24954
HAT1 histone acetyltransferase 1 2.24701
LOC102724594 splicing factor U2AF 35 kDa subunit 2.23792
CLDN5 claudin 5 2.21908
LPAR2 lysophosphatidic acid receptor 2 2.21268
KDR kinase insert domain receptor 2.19044
CD40 CD40 molecule, TNF receptor superfamily member 5 2.19007
DIPK1A divergent protein kinase domain 1A 2.09165
PECAM1 platelet/endothelial cell adhesion molecule 1 2.0913
LALBA lactalbumin, alpha- 2.07164
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.05904
REG3A regenerating islet-derived 3 alpha 2.04881
RASL10A RAS-like, family 10, member A 2.04691
PCDH12 protocadherin 12 2.04397
SPI1 Spi-1 proto-oncogene 2.03632
LRP6 low density lipoprotein receptor-related protein 6 2.03235
CYRIA CYFIP related Rac1 interactor A 2.01544
PRCC papillary renal cell carcinoma (translocation-associated) 2.01234
MMRN1 multimerin 1 2.00901
REG1A regenerating islet-derived 1 alpha 2.00618

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.39903
ZNF586 zinc finger protein 586 -7.44139
LDHD lactate dehydrogenase D -5.77444
PECR peroxisomal trans-2-enoyl-CoA reductase -5.59996
TXNDC9 thioredoxin domain containing 9 -3.79118
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.72942
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.7073
MAPK13 mitogen-activated protein kinase 13 -3.29257
OXA1L oxidase (cytochrome c) assembly 1-like -3.14924
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.96399
HMG20B high mobility group 20B -2.84363
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.80383
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.39588
SCCPDH saccharopine dehydrogenase (putative) -2.32256
ZMIZ1 zinc finger, MIZ-type containing 1 -2.26601
TBC1D31 TBC1 domain family, member 31 -2.15328
WDR7 WD repeat domain 7 -2.08077
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -2.06463
WASHC4 WASH complex subunit 4 -2.04014
CD58 CD58 molecule -2.00974