CRCGN014_HEPG2_3H:N08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description glutaraldehyde 38.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN014_HEPG2_3H:N08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.54419
EGR1 early growth response 1 6.50269
ANO1 anoctamin 1, calcium activated chloride channel 5.23352
ALDOC aldolase C, fructose-bisphosphate 4.307
JUN jun proto-oncogene 4.25657
HSPA1A heat shock 70kDa protein 1A 3.89291
MYLK myosin light chain kinase 3.66584
CCNF cyclin F 3.36832
ZFP36 ZFP36 ring finger protein 3.3112
TRIM13 tripartite motif containing 13 3.08202
JMJD6 jumonji domain containing 6 3.07789
STK10 serine/threonine kinase 10 3.03948
EPN2 epsin 2 2.96432
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.89425
CCP110 centriolar coiled coil protein 110kDa 2.73986
CEP57 centrosomal protein 57kDa 2.66113
DDIT4 DNA-damage-inducible transcript 4 2.64011
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.62257
TERF2IP telomeric repeat binding factor 2, interacting protein 2.60447
H2BC12 H2B clustered histone 12 2.5965
MAP7 microtubule-associated protein 7 2.53212
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.44175
BAMBI BMP and activin membrane-bound inhibitor 2.40793
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.40566
ZW10 zw10 kinetochore protein 2.40375
FOSL1 FOS-like antigen 1 2.35032
IER2 immediate early response 2 2.34502
HMOX1 heme oxygenase 1 2.31762
CYCS cytochrome c, somatic 2.3087
SSBP2 single-stranded DNA binding protein 2 2.27852
NKAPD1 NKAP domain containing 1 2.27295
SMC3 structural maintenance of chromosomes 3 2.23457
HYOU1 hypoxia up-regulated 1 2.16713
PPP4R3A protein phosphatase 4 regulatory subunit 3A 2.12333
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 2.09801
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.08103
THUMPD2 THUMP domain containing 2 2.05386
DIXDC1 DIX domain containing 1 2.04528
TOR1A torsin family 1, member A (torsin A) 2.01754
EXOSC4 exosome component 4 2.01322

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.84254
LDHD lactate dehydrogenase D -7.01889
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.49381
PCCB propionyl CoA carboxylase, beta polypeptide -5.61006
MYC v-myc avian myelocytomatosis viral oncogene homolog -4.69584
OXA1L oxidase (cytochrome c) assembly 1-like -4.63883
SLC35F2 solute carrier family 35, member F2 -4.60473
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -4.34004
PCNA proliferating cell nuclear antigen -3.98308
CCNB1 cyclin B1 -3.97902
TRIB3 tribbles pseudokinase 3 -3.31502
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.28291
PSRC1 proline/serine-rich coiled-coil 1 -3.27426
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.25132
DERA deoxyribose-phosphate aldolase (putative) -3.2231
VAT1 vesicle amine transport 1 -3.04681
PEG10 paternally expressed 10 -2.76538
ADAM10 ADAM metallopeptidase domain 10 -2.74335
NRIP1 nuclear receptor interacting protein 1 -2.53703
CD320 CD320 molecule -2.51218
ARID5B AT rich interactive domain 5B (MRF1-like) -2.3855
CGB8 chorionic gonadotropin, beta polypeptide 8 -2.37645
TBPL1 TBP-like 1 -2.36085
BIRC2 baculoviral IAP repeat containing 2 -2.25025
TXNDC9 thioredoxin domain containing 9 -2.16971
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.1198
PDCD6 programmed cell death 6 -2.06666
TLCD3A TLC domain containing 3A -2.03757
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.03475
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -2.0144
GJA1 gap junction protein, alpha 1, 43kDa -2.00778