CRCGN014_HEPG2_3H:N10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium (e)-4-hydroxy-3-((4-sulfonatonaphthalen-1-yl)diazenyl)naphthalene-1-sulfonate 21.89 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

26 genes differentially expressed following the CRCGN014_HEPG2_3H:N10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.66953
PPARG peroxisome proliferator-activated receptor gamma 4.44903
CYCS cytochrome c, somatic 3.87516
JADE2 jade family PHD finger 2 3.66428
ABHD6 abhydrolase domain containing 6 3.29147
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.11283
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.7802
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.46699
ECH1 enoyl CoA hydratase 1, peroxisomal 2.20411
JOSD1 Josephin domain containing 1 2.15102
RAP1GAP RAP1 GTPase activating protein 2.02701
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.01048
GATA2 GATA binding protein 2 2.0032

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.12938
MAPK13 mitogen-activated protein kinase 13 -4.45076
STAT1 signal transducer and activator of transcription 1, 91kDa -4.37293
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.30228
TXNDC9 thioredoxin domain containing 9 -3.21343
CDC20 cell division cycle 20 -3.09598
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.96164
PECR peroxisomal trans-2-enoyl-CoA reductase -2.89319
TOR1A torsin family 1, member A (torsin A) -2.84168
OXA1L oxidase (cytochrome c) assembly 1-like -2.71484
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.50709
SNX11 sorting nexin 11 -2.27319
FUBP3 far upstream element (FUSE) binding protein 3 -2.00767