CRCGN014_HEPG2_3H:N11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aroclor 1016 38.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN014_HEPG2_3H:N11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.69376
DDIT4 DNA-damage-inducible transcript 4 5.96402
MAP7 microtubule-associated protein 7 4.25672
EVL Enah/Vasp-like 3.94146
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.66419
PPARG peroxisome proliferator-activated receptor gamma 3.66104
IER3 immediate early response 3 3.51414
ABHD6 abhydrolase domain containing 6 3.11038
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.06212
EPHB2 EPH receptor B2 2.96003
TRIB1 tribbles pseudokinase 1 2.88757
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.74824
RAB21 RAB21, member RAS oncogene family 2.74576
PRR15L proline rich 15-like 2.64145
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.58224
TRIB3 tribbles pseudokinase 3 2.51675
CIAO3 cytosolic iron-sulfur assembly component 3 2.49813
GSTZ1 glutathione S-transferase zeta 1 2.47558
EPHA3 EPH receptor A3 2.47182
CHN1 chimerin 1 2.42419
SNAP25 synaptosomal-associated protein, 25kDa 2.36146
EGR1 early growth response 1 2.35996
DIPK1A divergent protein kinase domain 1A 2.31736
ATP11B ATPase, class VI, type 11B 2.30227
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.28919
CLDN4 claudin 4 2.2503
SNX7 sorting nexin 7 2.23976
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.20577
ADRB2 adrenoceptor beta 2, surface 2.17124
VGLL4 vestigial-like family member 4 2.13694
FOSL1 FOS-like antigen 1 2.13273
TIAM1 T-cell lymphoma invasion and metastasis 1 2.10911
CORO2A coronin, actin binding protein, 2A 2.10788
PEX11A peroxisomal biogenesis factor 11 alpha 2.09576
COPS7A COP9 signalosome subunit 7A 2.08312

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -6.91002
LDHD lactate dehydrogenase D -6.61992
TLR4 toll-like receptor 4 -5.8297
MAPK13 mitogen-activated protein kinase 13 -5.54838
ZNF586 zinc finger protein 586 -5.33629
UGDH UDP-glucose 6-dehydrogenase -4.87712
NGRN neugrin, neurite outgrowth associated -4.40292
PCCB propionyl CoA carboxylase, beta polypeptide -4.03636
GRWD1 glutamate-rich WD repeat containing 1 -3.82885
C2CD5 C2 calcium-dependent domain containing 5 -3.54293
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.30091
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.62221
SNX11 sorting nexin 11 -2.4788
TMEM97 transmembrane protein 97 -2.4721
PECR peroxisomal trans-2-enoyl-CoA reductase -2.45781
CDC25B cell division cycle 25B -2.31633
BLCAP bladder cancer associated protein -2.29638
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.25194
GNAS GNAS complex locus -2.13772
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.11661
PSRC1 proline/serine-rich coiled-coil 1 -2.07425
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.0363
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 -2.02817