CRCGN014_HEPG2_3H:N12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vorinostat 21.32 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

338 genes differentially expressed following the CRCGN014_HEPG2_3H:N12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRKCD protein kinase C, delta 7.80644
TBPL1 TBP-like 1 7.23637
CGRRF1 cell growth regulator with ring finger domain 1 7.05382
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 6.22875
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 5.8683
CCND3 cyclin D3 5.7161
FOXO4 forkhead box O4 5.60777
HSPA1A heat shock 70kDa protein 1A 5.57928
ALAS1 5'-aminolevulinate synthase 1 5.53049
CYCS cytochrome c, somatic 5.41348
PLA2G15 phospholipase A2, group XV 5.40451
STX1A syntaxin 1A (brain) 5.36834
STXBP1 syntaxin binding protein 1 5.18051
CDK7 cyclin-dependent kinase 7 5.07393
ALDOC aldolase C, fructose-bisphosphate 5.03428
CORO1A coronin, actin binding protein, 1A 4.60026
PTPN1 protein tyrosine phosphatase, non-receptor type 1 4.21501
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.00917
CCL2 chemokine (C-C motif) ligand 2 3.9379
GLRX glutaredoxin (thioltransferase) 3.93479
C2CD2 C2 calcium-dependent domain containing 2 3.8818
CARMIL1 capping protein regulator and myosin 1 linker 1 3.70953
HOXA10 homeobox A10 3.65688
PLSCR1 phospholipid scramblase 1 3.62972
BAG3 BCL2-associated athanogene 3 3.60288
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.5886
AMDHD2 amidohydrolase domain containing 2 3.55471
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.50108
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 3.4825
CBR1 carbonyl reductase 1 3.40308
SQOR sulfide quinone oxidoreductase 3.22901
BTK Bruton agammaglobulinemia tyrosine kinase 3.22207
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.20042
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.15189
MCOLN1 mucolipin 1 3.12363
MPC1 mitochondrial pyruvate carrier 1 3.11522
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3.09447
CHMP6 charged multivesicular body protein 6 3.05614
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 3.0485
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 3.00474
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 2.99921
MAP7 microtubule-associated protein 7 2.99294
GPN3 GPN-loop GTPase 3 2.99003
IL1B interleukin 1, beta 2.94105
ATG2A autophagy related 2A 2.93828
RND1 Rho family GTPase 1 2.90599
NOTCH1 notch 1 2.86879
OPLAH 5-oxoprolinase (ATP-hydrolysing) 2.84844
MTMR14 myotubularin related protein 14 2.7704
WDR47 WD repeat domain 47 2.76828
BLCAP bladder cancer associated protein 2.76769
ICAM1 intercellular adhesion molecule 1 2.73628
TBC1D10C TBC1 domain family, member 10C 2.71035
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.70483
CNPY4 canopy FGF signaling regulator 4 2.70304
TRAK2 trafficking protein, kinesin binding 2 2.68137
NCOA3 nuclear receptor coactivator 3 2.64226
IFT52 intraflagellar transport 52 2.63895
PRPF38B pre-mRNA processing factor 38B 2.62629
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2.61846
ASB6 ankyrin repeat and SOCS box containing 6 2.60592
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.59211
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.56692
FZD7 frizzled class receptor 7 2.55274
ZDHHC6 zinc finger, DHHC-type containing 6 2.53856
HMOX1 heme oxygenase 1 2.52705
SETD3 SET domain containing 3 2.49271
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 2.48978
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.47125
ELOVL6 ELOVL fatty acid elongase 6 2.46969
TUBA4A tubulin, alpha 4a 2.4649
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.45181
MLF1 myeloid leukemia factor 1 2.44289
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.42374
FAM117A family with sequence similarity 117, member A 2.41554
RBKS ribokinase 2.40764
DZANK1 double zinc ribbon and ankyrin repeat domains 1 2.39563
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 2.37909
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.36713
SPEG SPEG complex locus 2.33549
FABP3 fatty acid binding protein 3, muscle and heart 2.33442
YPEL5 yippee-like 5 (Drosophila) 2.33115
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.32136
HMG20B high mobility group 20B 2.3174
ROGDI rogdi homolog (Drosophila) 2.30116
ASRGL1 asparaginase like 1 2.29988
IER5 immediate early response 5 2.29878
FGD6 FYVE, RhoGEF and PH domain containing 6 2.29584
PNKP polynucleotide kinase 3'-phosphatase 2.29566
PPY pancreatic polypeptide 2.27962
WDR19 WD repeat domain 19 2.27899
SCPEP1 serine carboxypeptidase 1 2.27154
TRNAU1AP tRNA selenocysteine 1 associated protein 1 2.26849
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 2.26771
IQCC IQ motif containing C 2.25592
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.25545
ZNF205 zinc finger protein 205 2.23312
RECK reversion-inducing-cysteine-rich protein with kazal motifs 2.23204
GAS6 growth arrest-specific 6 2.22814
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 2.22386
LPAR2 lysophosphatidic acid receptor 2 2.21065
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.19217
HSPA1B heat shock 70kDa protein 1B 2.19155
TSPYL5 TSPY-like 5 2.18747
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.16061
CHUK conserved helix-loop-helix ubiquitous kinase 2.14541
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.14514
GADD45B growth arrest and DNA-damage-inducible, beta 2.1449
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.13452
SALL2 spalt-like transcription factor 2 2.13223
CEP131 centrosomal protein 131kDa 2.11886
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 2.11361
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2.10795
GPATCH8 G patch domain containing 8 2.09491
SFTPB surfactant protein B 2.08851
SHARPIN SHANK-associated RH domain interactor 2.08089
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.07912
PLCH2 phospholipase C, eta 2 2.07907
NEK11 NIMA-related kinase 11 2.0787
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.07715
ASMTL acetylserotonin O-methyltransferase-like 2.06698
TSPYL2 TSPY-like 2 2.05863
TBP TATA box binding protein 2.0576
CAMLG calcium modulating ligand 2.04763
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.04632
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.04601
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.04249
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 2.04062
FCHO1 FCH domain only 1 2.03459
MAGEH1 melanoma antigen family H1 2.03187
LOC122526780 uncharacterized LOC122526780 2.0205
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 2.01446
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.008
TTLL3 tubulin tyrosine ligase-like family member 3 2.00402

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -9.25376
KEAP1 kelch-like ECH-associated protein 1 -8.61616
TCERG1 transcription elongation regulator 1 -7.539
CD320 CD320 molecule -7.02115
MYC v-myc avian myelocytomatosis viral oncogene homolog -6.97368
SPAG4 sperm associated antigen 4 -6.77792
CCNB2 cyclin B2 -6.11897
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.79024
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.73997
TRIB3 tribbles pseudokinase 3 -5.65245
TLR4 toll-like receptor 4 -5.50543
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.22008
SLC35F2 solute carrier family 35, member F2 -4.96076
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.68811
TLCD3A TLC domain containing 3A -4.64011
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.60858
ISOC1 isochorismatase domain containing 1 -4.32452
CCNB1 cyclin B1 -4.28916
SCAND1 SCAN domain containing 1 -4.15668
C2CD5 C2 calcium-dependent domain containing 5 -4.1205
FOSL1 FOS-like antigen 1 -3.96052
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.93613
AURKB aurora kinase B -3.76749
FGFR4 fibroblast growth factor receptor 4 -3.72537
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.52565
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.50604
NUP62 nucleoporin 62kDa -3.48276
ACAA1 acetyl-CoA acyltransferase 1 -3.36444
GRWD1 glutamate-rich WD repeat containing 1 -3.2371
BIRC2 baculoviral IAP repeat containing 2 -3.22683
AQP9 aquaporin 9 -3.07279
SMYD5 SMYD family member 5 -3.04323
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -3.00135
TCEAL4 transcription elongation factor A (SII)-like 4 -2.94542
NT5DC2 5'-nucleotidase domain containing 2 -2.9421
NRIP1 nuclear receptor interacting protein 1 -2.90272
TSKU tsukushi, small leucine rich proteoglycan -2.88652
RRAGA Ras-related GTP binding A -2.8616
FOXM1 forkhead box M1 -2.83503
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.82085
LDHD lactate dehydrogenase D -2.77489
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.75106
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 -2.73447
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.71521
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.69958
MRPS2 mitochondrial ribosomal protein S2 -2.68794
GNAS GNAS complex locus -2.66161
RGS2 regulator of G-protein signaling 2 -2.66079
MPDU1 mannose-P-dolichol utilization defect 1 -2.65784
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -2.65658
NEUROD2 neuronal differentiation 2 -2.64623
USP22 ubiquitin specific peptidase 22 -2.63649
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.61891
GBP2 guanylate binding protein 2, interferon-inducible -2.60939
MTA1 metastasis associated 1 -2.60406
AOC2 amine oxidase, copper containing 2 (retina-specific) -2.59346
MRM3 mitochondrial rRNA methyltransferase 3 -2.5806
CDK6 cyclin-dependent kinase 6 -2.57419
CXCR1 chemokine (C-X-C motif) receptor 1 -2.56717
TMEM11 transmembrane protein 11 -2.56047
TEAD4 TEA domain family member 4 -2.56041
XPOT exportin, tRNA -2.55661
BTNL2 butyrophilin-like 2 -2.55269
PLK1 polo-like kinase 1 -2.54838
SDCBP syndecan binding protein (syntenin) -2.52565
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 -2.52018
KRT38 keratin 38, type I -2.51431
KLF15 Kruppel-like factor 15 -2.50174
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) -2.49864
TRIB1 tribbles pseudokinase 1 -2.49673
NLE1 notchless homolog 1 (Drosophila) -2.49343
FXN frataxin -2.49186
CTCF CCCTC-binding factor (zinc finger protein) -2.47976
WDR18 WD repeat domain 18 -2.46454
MRPL12 mitochondrial ribosomal protein L12 -2.46396
HOXB8 homeobox B8 -2.46047
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.45723
HSPA8 heat shock 70kDa protein 8 -2.45684
NAT10 N-acetyltransferase 10 (GCN5-related) -2.43664
FAT1 FAT atypical cadherin 1 -2.43591
TIMCC TIM double twin CX3C motif chaperone -2.43203
CCDC86 coiled-coil domain containing 86 -2.42812
GNRH2 gonadotropin-releasing hormone 2 -2.42423
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.42012
TTLL12 tubulin tyrosine ligase-like family member 12 -2.4153
KIF4A kinesin family member 4A -2.41456
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.40781
BYSL bystin-like -2.37701
ZP2 zona pellucida glycoprotein 2 (sperm receptor) -2.37268
ZNF324B zinc finger protein 324B -2.37177
SMIM10L1 small integral membrane protein 10 like 1 -2.36551
TNK1 tyrosine kinase, non-receptor, 1 -2.35674
THRB thyroid hormone receptor, beta -2.33706
CASC3 cancer susceptibility candidate 3 -2.32861
CDX4 caudal type homeobox 4 -2.31952
WDR7 WD repeat domain 7 -2.31621
BPY2B basic charge, Y-linked, 2B -2.30168
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.29879
ZNF134 zinc finger protein 134 -2.29754
FOXN2 forkhead box N2 -2.29668
SLC39A2 solute carrier family 39 (zinc transporter), member 2 -2.29534
CCNA2 cyclin A2 -2.29461
TLR8 toll-like receptor 8 -2.29005
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.28802
ZNF146 zinc finger protein 146 -2.28738
APOL6 apolipoprotein L, 6 -2.28299
TXLNA taxilin alpha -2.27968
CPNE2 copine II -2.2793
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.27517
BTN3A2 butyrophilin, subfamily 3, member A2 -2.27076
TACR1 tachykinin receptor 1 -2.26305
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -2.25869
ZXDA zinc finger, X-linked, duplicated A -2.25639
ASGR2 asialoglycoprotein receptor 2 -2.25228
ZNF208 zinc finger protein 208 -2.25156
METTL13 methyltransferase like 13 -2.24485
SNX11 sorting nexin 11 -2.24357
PARP2 poly (ADP-ribose) polymerase 2 -2.24099
KRT33B keratin 33B, type I -2.23897
SYNGR4 synaptogyrin 4 -2.23882
YME1L1 YME1-like 1 ATPase -2.23342
MRPS18B mitochondrial ribosomal protein S18B -2.23313
CTSL cathepsin L -2.23069
PODNL1 podocan-like 1 -2.22928
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) -2.22377
ZNF282 zinc finger protein 282 -2.21636
BMP4 bone morphogenetic protein 4 -2.2149
EMG1 EMG1 N1-specific pseudouridine methyltransferase -2.21427
SIGLEC5 sialic acid binding Ig-like lectin 5 -2.20007
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit -2.19812
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -2.19594
ARAF A-Raf proto-oncogene, serine/threonine kinase -2.19568
PES1 pescadillo ribosomal biogenesis factor 1 -2.19444
RAB11FIP2 RAB11 family interacting protein 2 (class I) -2.19345
CABP5 calcium binding protein 5 -2.1929
LYPLA1 lysophospholipase I -2.1909
GALR3 galanin receptor 3 -2.18919
GJB4 gap junction protein, beta 4, 30.3kDa -2.17838
SPAG7 sperm associated antigen 7 -2.17786
MICALL1 MICAL-like 1 -2.17092
FNBP4 formin binding protein 4 -2.16835
SOX5 SRY (sex determining region Y)-box 5 -2.16784
TRIM25 tripartite motif containing 25 -2.16315
APOBEC3A_B APOBEC3A and APOBEC3B deletion hybrid -2.16152
QPCTL glutaminyl-peptide cyclotransferase-like -2.15212
PYGL phosphorylase, glycogen, liver -2.15131
ACOD1 aconitate decarboxylase 1 -2.15031
FAM120C family with sequence similarity 120C -2.14881
ERN1 endoplasmic reticulum to nucleus signaling 1 -2.14341
DEFA3 defensin, alpha 3, neutrophil-specific -2.14045
DNAH2 dynein, axonemal, heavy chain 2 -2.13835
RCC1L RCC1 like -2.13173
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -2.12214
TLX3 T-cell leukemia homeobox 3 -2.11736
TRPM6 transient receptor potential cation channel, subfamily M, member 6 -2.11643
ZIM2 zinc finger, imprinted 2 -2.11623
FPR2 formyl peptide receptor 2 -2.11584
SMNDC1 survival motor neuron domain containing 1 -2.11507
RXRG retinoid X receptor, gamma -2.11453
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 -2.10506
MELTF melanotransferrin -2.10434
SMG9 SMG9 nonsense mediated mRNA decay factor -2.10034
MSH6 mutS homolog 6 -2.0999
ASIC1 acid sensing (proton gated) ion channel 1 -2.09625
FPR1 formyl peptide receptor 1 -2.09556
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -2.09507
CCNH cyclin H -2.09181
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -2.08765
PSORS1C2 psoriasis susceptibility 1 candidate 2 -2.08659
NPAP1 nuclear pore associated protein 1 -2.08386
CADM3 cell adhesion molecule 3 -2.07613
HOXB5 homeobox B5 -2.0757
WNT3 wingless-type MMTV integration site family, member 3 -2.07554
UMPS uridine monophosphate synthetase -2.06931
CCR8 chemokine (C-C motif) receptor 8 -2.06832
KLF3 Kruppel-like factor 3 (basic) -2.06574
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 -2.06447
FBXO7 F-box protein 7 -2.06325
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit -2.06061
MC5R melanocortin 5 receptor -2.05981
TXNRD1 thioredoxin reductase 1 -2.05978
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -2.05165
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -2.05042
COL5A2 collagen, type V, alpha 2 -2.04845
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.04713
DEAF1 DEAF1 transcription factor -2.04604
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.03953
DEPDC1 DEP domain containing 1 -2.0393
POU3F3 POU class 3 homeobox 3 -2.03867
MIS18BP1 MIS18 binding protein 1 -2.03523
RPP38 ribonuclease P/MRP 38kDa subunit -2.03436
CDK1 cyclin-dependent kinase 1 -2.03402
LRP3 low density lipoprotein receptor-related protein 3 -2.02697
DEFB126 defensin, beta 126 -2.02584
TLR6 toll-like receptor 6 -2.02562
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.02488
GREB1L growth regulation by estrogen in breast cancer-like -2.02064
PRRX1 paired related homeobox 1 -2.01179
CDCA3 cell division cycle associated 3 -2.00985
MEPE matrix extracellular phosphoglycoprotein -2.00694
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.00606
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 -2.00192
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -2.00035
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -2.00029