CRCGN014_HEPG2_3H:N13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN014_HEPG2_3H:N13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.27181
UBQLN2 ubiquilin 2 4.82575
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.57845
NOTCH1 notch 1 3.92917
PEX11A peroxisomal biogenesis factor 11 alpha 3.64526
TIAM1 T-cell lymphoma invasion and metastasis 1 3.43042
RPP38 ribonuclease P/MRP 38kDa subunit 3.31497
SFTPB surfactant protein B 3.15529
CHN1 chimerin 1 2.69085
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.49498
DIPK1A divergent protein kinase domain 1A 2.47563
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.43804
SATB1 SATB homeobox 1 2.26042
MRPL12 mitochondrial ribosomal protein L12 2.17027
ZBTB18 zinc finger and BTB domain containing 18 2.16661
BCL7B B-cell CLL/lymphoma 7B 2.14275
KMT5B lysine methyltransferase 5B 2.11839
SIRT3 sirtuin 3 2.10371
LOC128966622 putative protein N-methyltransferase FAM86B2 2.09798

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -9.04154
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.73986
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.95261
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.79784
TSPAN4 tetraspanin 4 -4.68334
PRPF4 pre-mRNA processing factor 4 -4.59062
PCNA proliferating cell nuclear antigen -4.38668
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.336
GNAS GNAS complex locus -3.84423
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.55789
TLCD3A TLC domain containing 3A -2.81962
LOC124907782 dual specificity protein phosphatase 22 -2.81339
WDR7 WD repeat domain 7 -2.66293
WASHC4 WASH complex subunit 4 -2.36821
CHEK1 checkpoint kinase 1 -2.32158
RGS2 regulator of G-protein signaling 2 -2.13943
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -2.03873