CRCGN014_HEPG2_3H:N14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN014_HEPG2_3H:N14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 9.09605
CBR3 carbonyl reductase 3 5.07638
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.96237
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.64716
PPARG peroxisome proliferator-activated receptor gamma 4.46606
ANO1 anoctamin 1, calcium activated chloride channel 4.36556
MAP7 microtubule-associated protein 7 3.77529
DHRS7 dehydrogenase/reductase (SDR family) member 7 3.16685
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.09984
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.87945
ARID4B AT rich interactive domain 4B (RBP1-like) 2.6226
SYCP2 synaptonemal complex protein 2 2.47736
COPS7A COP9 signalosome subunit 7A 2.47022
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.38008
SIRT3 sirtuin 3 2.34661
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.29209
ACSL5 acyl-CoA synthetase long-chain family member 5 2.29079
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.20439
LYRM1 LYR motif containing 1 2.19877
CD63 CD63 molecule 2.16553
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.16028
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.12844
ADAT1 adenosine deaminase, tRNA-specific 1 2.10067
JADE2 jade family PHD finger 2 2.07124
GYS1 glycogen synthase 1 (muscle) 2.04872
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 2.03168
ANKRD40 ankyrin repeat domain 40 2.01342

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.68934
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.81311
LDHD lactate dehydrogenase D -4.69522
GOLT1B golgi transport 1B -4.21355
PCNA proliferating cell nuclear antigen -4.04477
TBC1D31 TBC1 domain family, member 31 -3.78202
PRPF4 pre-mRNA processing factor 4 -3.64709
OXA1L oxidase (cytochrome c) assembly 1-like -2.75783
IPO13 importin 13 -2.74064
MAT2A methionine adenosyltransferase II, alpha -2.7175
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.63615