CRCGN014_HEPG2_3H:N17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-chloro?aniline) 38.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN014_HEPG2_3H:N17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 7.66469
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.03074
CYCS cytochrome c, somatic 4.52718
PPARG peroxisome proliferator-activated receptor gamma 3.89902
AMDHD2 amidohydrolase domain containing 2 3.68311
MAP7 microtubule-associated protein 7 3.57663
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.29846
BZW2 basic leucine zipper and W2 domains 2 3.12971
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.8935
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.87401
GOLT1B golgi transport 1B 2.8526
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.84876
TRIB3 tribbles pseudokinase 3 2.83435
ADRB2 adrenoceptor beta 2, surface 2.812
KDM5A lysine (K)-specific demethylase 5A 2.73142
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.71954
PEX11A peroxisomal biogenesis factor 11 alpha 2.55191
KIF20A kinesin family member 20A 2.51366
SAA2 serum amyloid A2 2.46645
SSBP2 single-stranded DNA binding protein 2 2.39985
RXYLT1 ribitol xylosyltransferase 1 2.33845
ZNF589 zinc finger protein 589 2.33284
CHMP6 charged multivesicular body protein 6 2.31375
MICALL1 MICAL-like 1 2.27515
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.25107
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 2.22607
ZBTB18 zinc finger and BTB domain containing 18 2.11719
CCP110 centriolar coiled coil protein 110kDa 2.10586
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.07265
NPDC1 neural proliferation, differentiation and control, 1 2.02055
LPAR2 lysophosphatidic acid receptor 2 2.016
MCUR1 mitochondrial calcium uniporter regulator 1 2.01157

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.83105
TUBB6 tubulin, beta 6 class V -5.00112
MRPS2 mitochondrial ribosomal protein S2 -3.92931
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.80456
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.71079
CCNB2 cyclin B2 -3.47652
VAT1 vesicle amine transport 1 -3.29164
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.8862
ZNF586 zinc finger protein 586 -2.46821
LDHD lactate dehydrogenase D -2.39924
CD320 CD320 molecule -2.31393
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.30639
GNAS GNAS complex locus -2.21643
GRWD1 glutamate-rich WD repeat containing 1 -2.03576
WASHC4 WASH complex subunit 4 -2.0013