CRCGN014_HEPG2_3H:N21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)benzenesulfonate 20.68 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN014_HEPG2_3H:N21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.94272
MAMLD1 mastermind-like domain containing 1 5.1701
MAP7 microtubule-associated protein 7 5.05059
ZNF589 zinc finger protein 589 3.71163
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.51969
CSK c-src tyrosine kinase 3.50357
UBQLN2 ubiquilin 2 3.27416
PLSCR1 phospholipid scramblase 1 3.23716
MYLK myosin light chain kinase 3.05724
CBR3 carbonyl reductase 3 3.00332
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.003
CYCS cytochrome c, somatic 2.75616
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.72409
PLSCR3 phospholipid scramblase 3 2.71704
STXBP2 syntaxin binding protein 2 2.56584
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.50637
CHMP6 charged multivesicular body protein 6 2.50096
MSRA methionine sulfoxide reductase A 2.46005
HOXA10 homeobox A10 2.05399
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.0341

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -6.61685
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.48929
ZNF586 zinc finger protein 586 -6.41163
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -6.38074
OXA1L oxidase (cytochrome c) assembly 1-like -4.04966
KDM3A lysine (K)-specific demethylase 3A -3.44909
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.40533
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.28672
REEP5 receptor accessory protein 5 -2.81884
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.69183
LDHD lactate dehydrogenase D -2.48299
SNX11 sorting nexin 11 -2.46861
XPO4 exportin 4 -2.18678
WASHC4 WASH complex subunit 4 -2.03321