CRCGN014_HEPG2_3H:N23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN014_HEPG2_3H:N23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 9.68278
UBQLN2 ubiquilin 2 6.7698
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.50863
MAP7 microtubule-associated protein 7 4.82465
INTS3 integrator complex subunit 3 4.37373
ADRB2 adrenoceptor beta 2, surface 4.07961
E2F2 E2F transcription factor 2 3.8504
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.84565
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.84534
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.63685
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.3769
GPATCH8 G patch domain containing 8 3.26
SFTPB surfactant protein B 2.973
SNAP25 synaptosomal-associated protein, 25kDa 2.94895
PRKCH protein kinase C, eta 2.60783
PLS1 plastin 1 2.54471
UFM1 ubiquitin-fold modifier 1 2.46946
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.41894
RRAGA Ras-related GTP binding A 2.40593
C1RL complement component 1, r subcomponent-like 2.38753
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.32524
TSPYL4 TSPY-like 4 2.22387
DYNLT3 dynein, light chain, Tctex-type 3 2.16246
SHH sonic hedgehog 2.11825
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.09545
TAPT1 transmembrane anterior posterior transformation 1 2.0809
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 2.02806
TRAPPC11 trafficking protein particle complex 11 2.02069
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) 2.01959
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 2.01247

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.75296
ZNF586 zinc finger protein 586 -6.09579
OXA1L oxidase (cytochrome c) assembly 1-like -5.34354
TUBB6 tubulin, beta 6 class V -4.5869
LDHD lactate dehydrogenase D -3.97029
CHMP4B charged multivesicular body protein 4B -3.36469
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.14857
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.99645
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.90435
TLCD3A TLC domain containing 3A -2.84366
CCNB2 cyclin B2 -2.81721
MTA1 metastasis associated 1 -2.44497
SNX11 sorting nexin 11 -2.44325
NCK1 NCK adaptor protein 1 -2.27285
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -2.21569
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.20747
CABIN1 calcineurin binding protein 1 -2.14618
PLK1 polo-like kinase 1 -2.13161
NSUN5 NOP2/Sun domain family, member 5 -2.08329
NFU1 NFU1 iron-sulfur cluster scaffold -2.02739
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.02592
NGRN neugrin, neurite outgrowth associated -2.0255