CRCGN014_HEPG2_3H:N24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

128 genes differentially expressed following the CRCGN014_HEPG2_3H:N24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.3742
AMDHD2 amidohydrolase domain containing 2 5.33486
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.12486
NOTCH1 notch 1 4.95455
CHMP6 charged multivesicular body protein 6 4.36195
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.29129
ADGRE5 adhesion G protein-coupled receptor E5 4.13226
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.04608
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.94079
TAC4 tachykinin 4 (hemokinin) 3.68765
DYNLT3 dynein, light chain, Tctex-type 3 3.53061
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.46507
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.34268
KIF14 kinesin family member 14 3.1685
BAX BCL2-associated X protein 3.15846
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.62191
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.50245
GALE UDP-galactose-4-epimerase 2.48037
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.17807
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.16641
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.15729
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.08503
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.02692
H2BC12 H2B clustered histone 12 2.00028

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.66988
CCNB1 cyclin B1 -4.73218
GNAS GNAS complex locus -4.67076
DNM1L dynamin 1-like -3.99527
HMG20B high mobility group 20B -3.87542
RAI14 retinoic acid induced 14 -3.86647
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.84896
LDHD lactate dehydrogenase D -3.44644
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.24958
OXA1L oxidase (cytochrome c) assembly 1-like -3.22753
EIF5 eukaryotic translation initiation factor 5 -3.17142
MRPS2 mitochondrial ribosomal protein S2 -3.04653
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.01365
TXNDC9 thioredoxin domain containing 9 -2.98345
BPHL biphenyl hydrolase-like (serine hydrolase) -2.91244
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 -2.90073
HMOX1 heme oxygenase 1 -2.66943
LPA lipoprotein, Lp(a) -2.65897
SYN3 synapsin III -2.56505
RIC3 RIC3 acetylcholine receptor chaperone -2.54973
CTXND1 cortexin domain containing 1 -2.47774
CSK c-src tyrosine kinase -2.47137
RIMS1 regulating synaptic membrane exocytosis 1 -2.45765
OR10J1 olfactory receptor, family 10, subfamily J, member 1 -2.43249
SLITRK3 SLIT and NTRK-like family, member 3 -2.42478
SPATA17 spermatogenesis associated 17 -2.40028
KIAA1549L KIAA1549-like -2.39815
STXBP5L syntaxin binding protein 5-like -2.38652
AFAP1 actin filament associated protein 1 -2.37836
SLITRK2 SLIT and NTRK-like family, member 2 -2.36911
GPR45 G protein-coupled receptor 45 -2.35908
GALR1 galanin receptor 1 -2.35446
ANKRD55 ankyrin repeat domain 55 -2.34082
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -2.32138
REM1 RAS (RAD and GEM)-like GTP-binding 1 -2.30211
BTG4 B-cell translocation gene 4 -2.29637
SNAP91 synaptosomal-associated protein, 91kDa -2.28933
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -2.27916
RAVER2 ribonucleoprotein, PTB-binding 2 -2.26976
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 -2.25732
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -2.25008
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.23484
EXOC6B exocyst complex component 6B -2.23443
PDE12 phosphodiesterase 12 -2.20754
BEX2 brain expressed X-linked 2 -2.20437
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 -2.20378
CAPN9 calpain 9 -2.20243
NSUN7 NOP2/Sun domain family, member 7 -2.19639
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 -2.19481
PURG purine-rich element binding protein G -2.18951
CCDC121 coiled-coil domain containing 121 -2.1824
ADH6 alcohol dehydrogenase 6 (class V) -2.17945
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.17271
KCNIP1 Kv channel interacting protein 1 -2.17017
TLL1 tolloid-like 1 -2.16804
TAS2R3 taste receptor, type 2, member 3 -2.16797
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.16773
THNSL1 threonine synthase-like 1 (S. cerevisiae) -2.16707
GPR85 G protein-coupled receptor 85 -2.16068
CEP72 centrosomal protein 72kDa -2.16029
GRK4 G protein-coupled receptor kinase 4 -2.15908
B3GAT1 beta-1,3-glucuronyltransferase 1 -2.15377
CNTN6 contactin 6 -2.14714
RORB RAR-related orphan receptor B -2.14644
GFM1 G elongation factor, mitochondrial 1 -2.13599
UBE3C ubiquitin protein ligase E3C -2.12991
SMAD9 SMAD family member 9 -2.12695
SPRYD7 SPRY domain containing 7 -2.11909
GRM5 glutamate receptor, metabotropic 5 -2.11395
GRM8 glutamate receptor, metabotropic 8 -2.10929
OR7A10 olfactory receptor, family 7, subfamily A, member 10 -2.10487
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 -2.09661
PACS1 phosphofurin acidic cluster sorting protein 1 -2.0962
TMOD2 tropomodulin 2 (neuronal) -2.09523
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -2.09495
TULP2 tubby like protein 2 -2.09246
NOX3 NADPH oxidase 3 -2.09227
SLC25A30 solute carrier family 25, member 30 -2.09055
OR1G1 olfactory receptor, family 1, subfamily G, member 1 -2.08976
TCP10L t-complex 10-like -2.08267
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 -2.08202
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 -2.08046
MLNR motilin receptor -2.07786
CRYBA4 crystallin, beta A4 -2.07483
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 -2.07243
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -2.0724
TAS2R8 taste receptor, type 2, member 8 -2.06619
KRTAP2-3 keratin associated protein 2-3 -2.06019
CDON cell adhesion associated, oncogene regulated -2.04324
SPO11 SPO11 meiotic protein covalently bound to DSB -2.03499
SCG3 secretogranin III -2.0339
OR1D2 olfactory receptor, family 1, subfamily D, member 2 -2.02553
LRRTM4 leucine rich repeat transmembrane neuronal 4 -2.02413
GPR32 G protein-coupled receptor 32 -2.02343
ZNF480 zinc finger protein 480 -2.0221
ZBTB3 zinc finger and BTB domain containing 3 -2.0199
COL19A1 collagen, type XIX, alpha 1 -2.01834
FAM163A family with sequence similarity 163, member A -2.01595
MSI1 musashi RNA-binding protein 1 -2.01589
SMCP sperm mitochondria-associated cysteine-rich protein -2.01297
KRTAP1-3 keratin associated protein 1-3 -2.01183
IKZF3 IKAROS family zinc finger 3 (Aiolos) -2.01123
ADCY10 adenylate cyclase 10 (soluble) -2.01074
VCY1B variable charge, Y-linked 1B -2.00073