CRCGN014_HEPG2_3H:O01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description TCDD-dioxin 0.05 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

221 genes differentially expressed following the CRCGN014_HEPG2_3H:O01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCDC92 coiled-coil domain containing 92 6.96082
PPARG peroxisome proliferator-activated receptor gamma 5.71414
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.3772
KCNK1 potassium channel, two pore domain subfamily K, member 1 5.24207
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.10428
TIAM1 T-cell lymphoma invasion and metastasis 1 4.95177
JADE2 jade family PHD finger 2 4.80983
AMDHD2 amidohydrolase domain containing 2 4.523
ADGRE5 adhesion G protein-coupled receptor E5 4.50024
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.37519
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.31821
SHB Src homology 2 domain containing adaptor protein B 4.13373
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.02736
TGFB3 transforming growth factor, beta 3 3.9784
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.91546
CIAO3 cytosolic iron-sulfur assembly component 3 3.62523
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.59338
RRAGA Ras-related GTP binding A 3.58923
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.53198
FZD7 frizzled class receptor 7 3.53152
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.45383
CRTAP cartilage associated protein 3.44007
PMM2 phosphomannomutase 2 3.30992
GPATCH8 G patch domain containing 8 3.30616
DIPK1A divergent protein kinase domain 1A 3.26591
CXCL2 chemokine (C-X-C motif) ligand 2 3.24645
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.17719
CBR3 carbonyl reductase 3 3.17408
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.16267
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.15236
ADRB2 adrenoceptor beta 2, surface 3.13303
CHMP6 charged multivesicular body protein 6 3.11963
LOC122526780 uncharacterized LOC122526780 2.91189
PRDM5 PR domain containing 5 2.89636
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.87249
NFIL3 nuclear factor, interleukin 3 regulated 2.8597
LPAR2 lysophosphatidic acid receptor 2 2.85035
SV2B synaptic vesicle glycoprotein 2B 2.81409
MEST mesoderm specific transcript 2.81061
RCVRN recoverin 2.77534
NENF neudesin neurotrophic factor 2.76687
CYTH1 cytohesin 1 2.75998
SFTPB surfactant protein B 2.71961
SIRT3 sirtuin 3 2.71795
MED22 mediator complex subunit 22 2.71177
RPL39L ribosomal protein L39-like 2.70548
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.69925
SMG9 SMG9 nonsense mediated mRNA decay factor 2.6679
TBC1D10C TBC1 domain family, member 10C 2.65923
HROB homologous recombination factor with OB-fold 2.64055
SYNGAP1 synaptic Ras GTPase activating protein 1 2.63701
ZIC3 Zic family member 3 2.60141
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.59822
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.5738
NINL ninein-like 2.57296
FZD1 frizzled class receptor 1 2.55829
ZNF589 zinc finger protein 589 2.54607
PLCG1 phospholipase C, gamma 1 2.53295
ERCC4 excision repair cross-complementation group 4 2.53294
PAX9 paired box 9 2.50839
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.47213
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.46851
RSF1 remodeling and spacing factor 1 2.46696
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.4611
PRKCD protein kinase C, delta 2.44906
LOC107985101 uncharacterized LOC107985101 2.44658
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 2.44614
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.41527
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 2.40988
TATDN2 TatD DNase domain containing 2 2.3728
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.37226
HPSE2 heparanase 2 (inactive) 2.3718
MAP3K6 mitogen-activated protein kinase kinase kinase 6 2.37045
CDC25B cell division cycle 25B 2.36307
BCL2L14 BCL2-like 14 (apoptosis facilitator) 2.36191
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.33736
CD151 CD151 molecule (Raph blood group) 2.30586
OR1G1 olfactory receptor, family 1, subfamily G, member 1 2.30213
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) 2.27989
CTSL cathepsin L 2.2647
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.26035
IDE insulin-degrading enzyme 2.25069
PTH2R parathyroid hormone 2 receptor 2.24049
SH3PXD2A SH3 and PX domains 2A 2.23651
CHRDL1 chordin-like 1 2.23177
STAP2 signal transducing adaptor family member 2 2.22235
RORB RAR-related orphan receptor B 2.2212
NT5DC2 5'-nucleotidase domain containing 2 2.21043
ANKRD34C ankyrin repeat domain 34C 2.20267
AGTR2 angiotensin II receptor, type 2 2.19732
CHN1 chimerin 1 2.18566
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.18476
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.16742
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.16734
SMG6 SMG6 nonsense mediated mRNA decay factor 2.16121
CIDEC cell death-inducing DFFA-like effector c 2.15658
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 2.15426
TARBP2 TAR (HIV-1) RNA binding protein 2 2.15064
ADAM20 ADAM metallopeptidase domain 20 2.13366
KCTD7 potassium channel tetramerization domain containing 7 2.12371
PGM5 phosphoglucomutase 5 2.11914
RBMS3 RNA binding motif, single stranded interacting protein 3 2.11874
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.11646
MYLK myosin light chain kinase 2.11579
PAX7 paired box 7 2.10935
PGC progastricsin (pepsinogen C) 2.10467
TAAR2 trace amine associated receptor 2 2.08637
CD70 CD70 molecule 2.081
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.08052
CHRM2 cholinergic receptor, muscarinic 2 2.08044
TEX10 testis expressed 10 2.07621
HSPA1A heat shock 70kDa protein 1A 2.0734
TRAF1 TNF receptor-associated factor 1 2.07283
CLDN15 claudin 15 2.06084
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.05474
CTSE cathepsin E 2.05115
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.04745
GATA3 GATA binding protein 3 2.04721
POM121L2 POM121 transmembrane nucleoporin-like 2 2.04701
ANO1 anoctamin 1, calcium activated chloride channel 2.04035
INF2 inverted formin, FH2 and WH2 domain containing 2.03071
SFRP1 secreted frizzled-related protein 1 2.02267
OR1D2 olfactory receptor, family 1, subfamily D, member 2 2.02241
RAP1GAP RAP1 GTPase activating protein 2.02043
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.01644
CTNNBIP1 catenin, beta interacting protein 1 2.01617
PCNA proliferating cell nuclear antigen 2.01348
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 2.00986
TSKU tsukushi, small leucine rich proteoglycan 2.00683
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 2.00534
MCHR1 melanin-concentrating hormone receptor 1 2.00497
STX17 syntaxin 17 2.00089

decreased expression

Symbol Name Standardized Value
TSEN2 TSEN2 tRNA splicing endonuclease subunit -6.70907
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -6.32321
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.7232
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.4344
OXA1L oxidase (cytochrome c) assembly 1-like -5.32275
LOC124907782 dual specificity protein phosphatase 22 -5.26904
ZNF586 zinc finger protein 586 -5.18297
ADI1 acireductone dioxygenase 1 -4.87306
CAB39 calcium binding protein 39 -4.81875
BPHL biphenyl hydrolase-like (serine hydrolase) -3.95861
SPAG4 sperm associated antigen 4 -3.94358
MAPK13 mitogen-activated protein kinase 13 -3.50802
TRIB3 tribbles pseudokinase 3 -3.40284
ZMIZ1 zinc finger, MIZ-type containing 1 -3.29561
GDF15 growth differentiation factor 15 -3.28707
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.23468
LAGE3 L antigen family, member 3 -3.16196
RFC2 replication factor C (activator 1) 2, 40kDa -3.05713
TCTN1 tectonic family member 1 -3.03826
RPN1 ribophorin I -3.00272
ANKRD10 ankyrin repeat domain 10 -2.88609
FOS FBJ murine osteosarcoma viral oncogene homolog -2.88125
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.83501
SCAND1 SCAN domain containing 1 -2.7914
RAI14 retinoic acid induced 14 -2.75964
AKAP8 A kinase (PRKA) anchor protein 8 -2.75823
TCEAL4 transcription elongation factor A (SII)-like 4 -2.71085
UGDH UDP-glucose 6-dehydrogenase -2.6955
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.67954
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.66628
POLH polymerase (DNA directed), eta -2.6125
CHEK1 checkpoint kinase 1 -2.60637
FKBP14 FK506 binding protein 14, 22 kDa -2.56566
CLTB clathrin, light chain B -2.55453
CIRBP cold inducible RNA binding protein -2.52501
MEF2C myocyte enhancer factor 2C -2.52497
CCNH cyclin H -2.51548
RNF167 ring finger protein 167 -2.48774
TICAM1 toll-like receptor adaptor molecule 1 -2.48626
GOLGA8F golgin A8 family, member F -2.47683
ATRAID all-trans retinoic acid-induced differentiation factor -2.45786
AUP1 ancient ubiquitous protein 1 -2.3946
DENND2D DENN/MADD domain containing 2D -2.38734
TM9SF3 transmembrane 9 superfamily member 3 -2.38607
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.35704
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough -2.34768
WDR7 WD repeat domain 7 -2.33
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -2.31341
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.29942
TOMM34 translocase of outer mitochondrial membrane 34 -2.28828
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.28009
IMPACT impact RWD domain protein -2.26633
BTBD1 BTB (POZ) domain containing 1 -2.25459
VEZT vezatin, adherens junctions transmembrane protein -2.24683
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -2.24383
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -2.21716
MACF1 microtubule-actin crosslinking factor 1 -2.20229
GGCT gamma-glutamylcyclotransferase -2.18046
ACYP2 acylphosphatase 2, muscle type -2.17398
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -2.15669
HTRA1 HtrA serine peptidase 1 -2.14858
RUVBL1 RuvB-like AAA ATPase 1 -2.14216
CDK9 cyclin-dependent kinase 9 -2.12347
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.1049
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.10296
TMEM208 transmembrane protein 208 -2.10295
PRCP prolylcarboxypeptidase (angiotensinase C) -2.10289
WASHC3 WASH complex subunit 3 -2.10009
VAMP8 vesicle-associated membrane protein 8 -2.09981
RPL26L1 ribosomal protein L26-like 1 -2.09669
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.07726
FTO fat mass and obesity associated -2.07577
RBM15 RNA binding motif protein 15 -2.07361
NUBPL nucleotide binding protein-like -2.0734
GEMIN6 gem (nuclear organelle) associated protein 6 -2.06618
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.06398
DUSP6 dual specificity phosphatase 6 -2.05989
PLSCR4 phospholipid scramblase 4 -2.05302
SSR1 signal sequence receptor, alpha -2.03563
SARAF store-operated calcium entry-associated regulatory factor -2.03166
MAPK12 mitogen-activated protein kinase 12 -2.02793
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.02694
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -2.02388
ZBTB10 zinc finger and BTB domain containing 10 -2.01774
LEMD3 LEM domain containing 3 -2.01377
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.01196
PTPRK protein tyrosine phosphatase, receptor type, K -2.01019
GOLT1B golgi transport 1B -2.00491
SEC61G Sec61 gamma subunit -2.0011