CRCGN014_HEPG2_3H:O02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description TCDD-dioxin 0.03 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

109 genes differentially expressed following the CRCGN014_HEPG2_3H:O02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 5.5385
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.4336
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.19155
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.10055
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.95395
E2F2 E2F transcription factor 2 4.71315
ADGRE5 adhesion G protein-coupled receptor E5 4.7053
BTK Bruton agammaglobulinemia tyrosine kinase 4.42955
PRKCH protein kinase C, eta 4.2134
SFTPB surfactant protein B 3.93645
ABHD6 abhydrolase domain containing 6 3.93625
MYLK myosin light chain kinase 3.79615
CCDC86 coiled-coil domain containing 86 3.6493
MAP7 microtubule-associated protein 7 3.49523
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.26505
GSTZ1 glutathione S-transferase zeta 1 3.2585
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.25515
TGFB3 transforming growth factor, beta 3 3.1574
GLI2 GLI family zinc finger 2 3.1066
SHB Src homology 2 domain containing adaptor protein B 3.10135
TAC4 tachykinin 4 (hemokinin) 3.0224
RAP1GAP RAP1 GTPase activating protein 2.98105
KIF14 kinesin family member 14 2.9536
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.9242
MAST2 microtubule associated serine/threonine kinase 2 2.89683
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.86435
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.82175
FAM120C family with sequence similarity 120C 2.6073
ANO1 anoctamin 1, calcium activated chloride channel 2.51755
HMG20B high mobility group 20B 2.4896
CD72 CD72 molecule 2.4849
KLRC4-KLRK1 KLRC4-KLRK1 readthrough 2.47695
CD180 CD180 molecule 2.47405
GPR68 G protein-coupled receptor 68 2.43015
PRR15L proline rich 15-like 2.4007
GPATCH8 G patch domain containing 8 2.39115
TLR6 toll-like receptor 6 2.3723
HCRT hypocretin (orexin) neuropeptide precursor 2.3545
PAX7 paired box 7 2.33805
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 2.33085
TLX3 T-cell leukemia homeobox 3 2.3294
MEST mesoderm specific transcript 2.2791
CST7 cystatin F (leukocystatin) 2.2726
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.2416
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.23408
VPREB3 pre-B lymphocyte 3 2.23295
HOXB8 homeobox B8 2.2261
PDE11A phosphodiesterase 11A 2.1996
KLRG1 killer cell lectin-like receptor subfamily G, member 1 2.19775
CRTAM cytotoxic and regulatory T cell molecule 2.18145
ABHD4 abhydrolase domain containing 4 2.1767
TEC tec protein tyrosine kinase 2.1583
TNF tumor necrosis factor 2.1225
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.11685
CXCL13 chemokine (C-X-C motif) ligand 13 2.1121
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.1105
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.0998
RHOH ras homolog family member H 2.09205
FLT3 fms-related tyrosine kinase 3 2.0614
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 2.04083
RUNX3 runt-related transcription factor 3 2.03375
CD79B CD79b molecule, immunoglobulin-associated beta 2.03105
FN3K fructosamine 3 kinase 2.02085
GPR18 G protein-coupled receptor 18 2.01955
COQ8A coenzyme Q8A 2.0141
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 2.00004

decreased expression

Symbol Name Standardized Value
TSEN2 TSEN2 tRNA splicing endonuclease subunit -5.98515
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0
SLC35F2 solute carrier family 35, member F2 -4.9973
SPAG4 sperm associated antigen 4 -4.9799
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.923
ZNF586 zinc finger protein 586 -4.8688
LDHD lactate dehydrogenase D -4.8668
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.6059
ARID5B AT rich interactive domain 5B (MRF1-like) -4.36015
OXA1L oxidase (cytochrome c) assembly 1-like -4.1446
GNAS GNAS complex locus -3.82287
TBC1D31 TBC1 domain family, member 31 -3.5735
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.4004
NGRN neugrin, neurite outgrowth associated -3.222
PEG10 paternally expressed 10 -2.98125
YME1L1 YME1-like 1 ATPase -2.94142
TCERG1 transcription elongation regulator 1 -2.8526
PRPF4 pre-mRNA processing factor 4 -2.79472
RFC2 replication factor C (activator 1) 2, 40kDa -2.76143
WDR7 WD repeat domain 7 -2.73785
BPHL biphenyl hydrolase-like (serine hydrolase) -2.7302
TCEAL4 transcription elongation factor A (SII)-like 4 -2.63795
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.4166
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.39885
RNF167 ring finger protein 167 -2.34585
TATDN2 TatD DNase domain containing 2 -2.2713
OXR1 oxidation resistance 1 -2.2678
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.2097
PECR peroxisomal trans-2-enoyl-CoA reductase -2.17455
CEP70 centrosomal protein 70kDa -2.16755
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.1504
GUK1 guanylate kinase 1 -2.13875
BIN3 bridging integrator 3 -2.1213
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.11755
STAP2 signal transducing adaptor family member 2 -2.1112
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.07325
EMC7 ER membrane protein complex subunit 7 -2.04045
TMX2 thioredoxin-related transmembrane protein 2 -2.03675
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -2.034
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.03205
PCDH9 protocadherin 9 -2.02842
TMEM208 transmembrane protein 208 -2.02475
AUP1 ancient ubiquitous protein 1 -2.02215