CRCGN014_HEPG2_3H:O03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tricresyl phosphate 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

196 genes differentially expressed following the CRCGN014_HEPG2_3H:O03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 10.0
DDIT4 DNA-damage-inducible transcript 4 9.66744
EGR1 early growth response 1 5.82481
NFIL3 nuclear factor, interleukin 3 regulated 5.74762
TRIB3 tribbles pseudokinase 3 5.05937
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.72878
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.48016
IER3 immediate early response 3 4.13604
CIAO3 cytosolic iron-sulfur assembly component 3 4.1221
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 4.08264
MINDY1 MINDY lysine 48 deubiquitinase 1 4.07136
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.83655
H2BC12 H2B clustered histone 12 3.82496
SCRN1 secernin 1 3.80694
AMDHD2 amidohydrolase domain containing 2 3.79409
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.70925
EPHB2 EPH receptor B2 3.58786
BHLHE40 basic helix-loop-helix family, member e40 3.44772
ZFP36 ZFP36 ring finger protein 3.40912
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.38342
MAP7 microtubule-associated protein 7 3.27295
AARS1 alanyl-tRNA synthetase 1 3.06684
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.04279
PLS1 plastin 1 3.03109
ICAM1 intercellular adhesion molecule 1 3.03045
SYNGAP1 synaptic Ras GTPase activating protein 1 3.01023
PNKP polynucleotide kinase 3'-phosphatase 2.9811
UBQLN2 ubiquilin 2 2.89635
PLSCR1 phospholipid scramblase 1 2.86581
BZW2 basic leucine zipper and W2 domains 2 2.85788
NT5DC2 5'-nucleotidase domain containing 2 2.83734
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.67716
PER1 period circadian clock 1 2.6475
IL4R interleukin 4 receptor 2.61981
SSBP2 single-stranded DNA binding protein 2 2.60527
KYAT3 kynurenine aminotransferase 3 2.5909
RALGDS ral guanine nucleotide dissociation stimulator 2.58723
CCP110 centriolar coiled coil protein 110kDa 2.58028
KRT86 keratin 86, type II 2.57657
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.56033
NNT nicotinamide nucleotide transhydrogenase 2.55766
FOSL1 FOS-like antigen 1 2.54716
MEST mesoderm specific transcript 2.53613
CASC3 cancer susceptibility candidate 3 2.53373
NARS1 asparaginyl-tRNA synthetase 1 2.48888
BAG3 BCL2-associated athanogene 3 2.45616
TIAM1 T-cell lymphoma invasion and metastasis 1 2.41087
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.40152
NUPR1 nuclear protein, transcriptional regulator, 1 2.39619
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.39573
TRIB1 tribbles pseudokinase 1 2.38858
HYOU1 hypoxia up-regulated 1 2.35157
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.3489
DENND2B DENN domain containing 2B 2.34183
DENND4C DENN/MADD domain containing 4C 2.3121
DIPK1A divergent protein kinase domain 1A 2.28762
CHEK2 checkpoint kinase 2 2.27734
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.26539
DUSP8 dual specificity phosphatase 8 2.2553
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.24958
CBX4 chromobox homolog 4 2.22281
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.20939
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.2086
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.20313
SORBS3 sorbin and SH3 domain containing 3 2.1889
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.18185
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.15572
NR1D1 nuclear receptor subfamily 1, group D, member 1 2.15287
CARS1 cysteinyl-tRNA synthetase 1 2.14419
IGF2R insulin-like growth factor 2 receptor 2.14335
SPAG7 sperm associated antigen 7 2.14137
JADE2 jade family PHD finger 2 2.12863
SHB Src homology 2 domain containing adaptor protein B 2.12334
DNM1L dynamin 1-like 2.11833
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.11591
CUX1 cut-like homeobox 1 2.09887
MAN2A1 mannosidase, alpha, class 2A, member 1 2.09151
TFEB transcription factor EB 2.08626
NCSTN nicastrin 2.07854
NCKIPSD NCK interacting protein with SH3 domain 2.07816
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.07702
PTK7 protein tyrosine kinase 7 (inactive) 2.05634
KLHL26 kelch-like family member 26 2.04644
WDR70 WD repeat domain 70 2.0404
SNAI1 snail family zinc finger 1 2.0378
PTK2 protein tyrosine kinase 2 2.03316
PHF2 PHD finger protein 2 2.02517
UFSP2 UFM1-specific peptidase 2 2.01661
CRYL1 crystallin, lambda 1 2.00938
YME1L1 YME1-like 1 ATPase 2.00013

decreased expression

Symbol Name Standardized Value
FASTKD5 FAST kinase domains 5 -9.94442
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -5.81437
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.73466
MAPK13 mitogen-activated protein kinase 13 -4.69191
SCAND1 SCAN domain containing 1 -4.60686
SMNDC1 survival motor neuron domain containing 1 -4.55531
CCNB2 cyclin B2 -4.52611
PSRC1 proline/serine-rich coiled-coil 1 -4.35453
CCDC86 coiled-coil domain containing 86 -3.86133
ZMIZ1 zinc finger, MIZ-type containing 1 -3.71949
CAB39 calcium binding protein 39 -3.66539
TOMM34 translocase of outer mitochondrial membrane 34 -3.62737
BPHL biphenyl hydrolase-like (serine hydrolase) -3.62428
THAP11 THAP domain containing 11 -3.57113
SLC35F2 solute carrier family 35, member F2 -3.47822
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.45915
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.37276
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.30879
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.24964
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -3.19284
CCNH cyclin H -3.13302
PLK1 polo-like kinase 1 -3.12368
RXYLT1 ribitol xylosyltransferase 1 -3.08863
TCEAL4 transcription elongation factor A (SII)-like 4 -3.07799
GLOD4 glyoxalase domain containing 4 -3.07158
EIF5 eukaryotic translation initiation factor 5 -3.06418
NVL nuclear VCP-like -3.03748
NUP93 nucleoporin 93kDa -3.01165
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.96096
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.95981
SOAT2 sterol O-acyltransferase 2 -2.92089
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.91421
CRYZ crystallin, zeta (quinone reductase) -2.86534
PRCP prolylcarboxypeptidase (angiotensinase C) -2.84014
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.82385
TROAP trophinin associated protein -2.79645
E2F3 E2F transcription factor 3 -2.77498
ELAC2 elaC ribonuclease Z 2 -2.76525
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.72206
TBC1D31 TBC1 domain family, member 31 -2.66662
TXLNA taxilin alpha -2.63882
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.62968
FAIM Fas apoptotic inhibitory molecule -2.55118
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.53687
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.52477
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.50812
MOK MOK protein kinase -2.50175
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -2.47625
LBHD1 LBH domain containing 1 -2.45982
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.44763
RGS19 regulator of G-protein signaling 19 -2.4436
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.44219
RIOX1 ribosomal oxygenase 1 -2.41886
MAT2A methionine adenosyltransferase II, alpha -2.39842
RPS27L ribosomal protein S27-like -2.38719
TXNRD1 thioredoxin reductase 1 -2.38531
TCTN1 tectonic family member 1 -2.38491
TBPL1 TBP-like 1 -2.38294
PEX11A peroxisomal biogenesis factor 11 alpha -2.38071
TM9SF2 transmembrane 9 superfamily member 2 -2.34175
ACAA1 acetyl-CoA acyltransferase 1 -2.33994
RUVBL1 RuvB-like AAA ATPase 1 -2.32835
UGDH UDP-glucose 6-dehydrogenase -2.32292
DYNLT3 dynein, light chain, Tctex-type 3 -2.30893
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.30879
NOP56 NOP56 ribonucleoprotein -2.30555
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.2932
DDB2 damage-specific DNA binding protein 2, 48kDa -2.28573
CDC20 cell division cycle 20 -2.28353
HEBP1 heme binding protein 1 -2.26322
SLIRP SRA stem-loop interacting RNA binding protein -2.25781
HJURP Holliday junction recognition protein -2.2508
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.23735
PAK1IP1 PAK1 interacting protein 1 -2.22432
ANXA7 annexin A7 -2.22409
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.21941
S100A4 S100 calcium binding protein A4 -2.20643
CDCA3 cell division cycle associated 3 -2.19096
WDCP WD repeat and coiled coil containing -2.18113
SORD sorbitol dehydrogenase -2.1793
PCTP phosphatidylcholine transfer protein -2.17768
NUP85 nucleoporin 85kDa -2.17677
IFRD2 interferon-related developmental regulator 2 -2.17254
EBNA1BP2 EBNA1 binding protein 2 -2.16565
PNPLA3 patatin-like phospholipase domain containing 3 -2.15691
NSG1 neuron specific gene family member 1 -2.15424
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.14252
CCNF cyclin F -2.13756
TFCP2 transcription factor CP2 -2.12716
ZNF586 zinc finger protein 586 -2.10701
KEAP1 kelch-like ECH-associated protein 1 -2.10673
REXO5 RNA exonuclease 5 -2.09482
RNASE7 ribonuclease, RNase A family, 7 -2.09236
ISOC1 isochorismatase domain containing 1 -2.06474
MKKS McKusick-Kaufman syndrome -2.05559
CRYGD crystallin, gamma D -2.03927
CAVIN3 caveolae associated protein 3 -2.03842
ETFB electron-transfer-flavoprotein, beta polypeptide -2.02836
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.02735
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) -2.02452
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -2.01919
CTSL cathepsin L -2.01694
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.01491
RLN1 relaxin 1 -2.01005
TOE1 target of EGR1, member 1 (nuclear) -2.0017
S100A13 S100 calcium binding protein A13 -2.00169