CRCGN014_HEPG2_3H:O07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K63993117 40.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN014_HEPG2_3H:O07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 10.0
CYCS cytochrome c, somatic 6.942
CXCL2 chemokine (C-X-C motif) ligand 2 5.15475
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.076
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.8559
SFTPB surfactant protein B 4.84133
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.7065
CARMIL1 capping protein regulator and myosin 1 linker 1 4.19715
MOK MOK protein kinase 3.82795
PLSCR1 phospholipid scramblase 1 3.81725
CEP57 centrosomal protein 57kDa 3.69064
ZBTB18 zinc finger and BTB domain containing 18 3.66113
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.45855
DENND2D DENN/MADD domain containing 2D 3.32645
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.29395
TIAM1 T-cell lymphoma invasion and metastasis 1 3.08323
GPATCH8 G patch domain containing 8 3.0259
TREM1 triggering receptor expressed on myeloid cells 1 3.0244
ABHD6 abhydrolase domain containing 6 3.0061
ZNF589 zinc finger protein 589 2.76203
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.64757
CCNF cyclin F 2.62827
PIH1D1 PIH1 domain containing 1 2.41495
JADE2 jade family PHD finger 2 2.33885
CCL2 chemokine (C-C motif) ligand 2 2.32485
NPDC1 neural proliferation, differentiation and control, 1 2.2814
LBHD1 LBH domain containing 1 2.25935
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.2335
NARS1 asparaginyl-tRNA synthetase 1 2.22995
CCDC86 coiled-coil domain containing 86 2.2271
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.2081
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.20425
MTERF3 mitochondrial transcription termination factor 3 2.1335
RRAGA Ras-related GTP binding A 2.13075
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.09875
KLK12 kallikrein-related peptidase 12 2.06635
PANX1 pannexin 1 2.02745

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CD320 CD320 molecule -5.59095
PRCP prolylcarboxypeptidase (angiotensinase C) -5.1313
UBE3C ubiquitin protein ligase E3C -4.1764
GNAS GNAS complex locus -3.59894
CCNH cyclin H -3.3967
NVL nuclear VCP-like -3.3724
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -3.3321
S100A4 S100 calcium binding protein A4 -2.75855
SPI1 Spi-1 proto-oncogene -2.5598
BIRC2 baculoviral IAP repeat containing 2 -2.5398
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.42798
CPNE3 copine III -2.34425
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.24875
MINDY3 MINDY lysine 48 deubiquitinase 3 -2.18085
COL17A1 collagen, type XVII, alpha 1 -2.1393
PUM3 pumilio RNA binding family member 3 -2.1184
SOX4 SRY (sex determining region Y)-box 4 -2.04464
PSIP1 PC4 and SFRS1 interacting protein 1 -2.04108
PHF10 PHD finger protein 10 -2.0336
SUN2 Sad1 and UNC84 domain containing 2 -2.0201