CRCGN014_HEPG2_3H:O08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description promethazine 40.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

152 genes differentially expressed following the CRCGN014_HEPG2_3H:O08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 9.91752
CYCS cytochrome c, somatic 7.3819
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.09504
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 6.82484
LPAR2 lysophosphatidic acid receptor 2 6.22365
MYC v-myc avian myelocytomatosis viral oncogene homolog 5.68822
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 5.54906
TRIB3 tribbles pseudokinase 3 5.14217
STAP2 signal transducing adaptor family member 2 5.06337
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 4.79161
RGS2 regulator of G-protein signaling 2 4.21849
JADE2 jade family PHD finger 2 4.19509
TNIP1 TNFAIP3 interacting protein 1 4.10075
TIMP2 TIMP metallopeptidase inhibitor 2 4.05743
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.91664
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.81705
CBR3 carbonyl reductase 3 3.76858
ADRB2 adrenoceptor beta 2, surface 3.67755
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.58664
TSC22D3 TSC22 domain family, member 3 3.57752
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 3.49657
JUN jun proto-oncogene 3.44407
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.35837
NOTCH1 notch 1 3.28977
WFS1 Wolfram syndrome 1 (wolframin) 3.28728
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.23537
CDK7 cyclin-dependent kinase 7 3.19067
TERF2IP telomeric repeat binding factor 2, interacting protein 3.05132
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.03261
CIAO3 cytosolic iron-sulfur assembly component 3 3.00367
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.99521
VGLL4 vestigial-like family member 4 2.8115
MAP7 microtubule-associated protein 7 2.79806
SQSTM1 sequestosome 1 2.76109
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.75776
CHN1 chimerin 1 2.75321
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.74082
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.71024
KIFBP kinesin family binding protein 2.69014
KDM3A lysine (K)-specific demethylase 3A 2.68887
ZNF423 zinc finger protein 423 2.65306
ABHD4 abhydrolase domain containing 4 2.59089
ICAM1 intercellular adhesion molecule 1 2.57096
TESK1 testis-specific kinase 1 2.55404
AARS1 alanyl-tRNA synthetase 1 2.51861
ATP13A1 ATPase type 13A1 2.51365
SARS1 seryl-tRNA synthetase 1 2.4504
GPATCH8 G patch domain containing 8 2.41278
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.36772
RHOG ras homolog family member G 2.34949
ADAM10 ADAM metallopeptidase domain 10 2.34735
NFIL3 nuclear factor, interleukin 3 regulated 2.33791
STX1A syntaxin 1A (brain) 2.33467
TIAM1 T-cell lymphoma invasion and metastasis 1 2.31572
GSTZ1 glutathione S-transferase zeta 1 2.27485
ZFP36 ZFP36 ring finger protein 2.27113
INPP1 inositol polyphosphate-1-phosphatase 2.20255
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.19364
ISG20 interferon stimulated exonuclease gene 20kDa 2.18542
UBE2A ubiquitin-conjugating enzyme E2A 2.1762
NOSIP nitric oxide synthase interacting protein 2.13877
H2BC12 H2B clustered histone 12 2.13323
ZHX2 zinc fingers and homeoboxes 2 2.11401
RAB31 RAB31, member RAS oncogene family 2.10721
EZR ezrin 2.10486
TUBG2 tubulin, gamma 2 2.08082
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.07439
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.04033

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.78767
LDHD lactate dehydrogenase D -6.46843
ZNF586 zinc finger protein 586 -5.8067
FASTKD5 FAST kinase domains 5 -5.62528
CDC20 cell division cycle 20 -5.00905
TLCD3A TLC domain containing 3A -5.00684
PCNA proliferating cell nuclear antigen -4.61596
BPHL biphenyl hydrolase-like (serine hydrolase) -4.60528
PSRC1 proline/serine-rich coiled-coil 1 -4.50174
PCCB propionyl CoA carboxylase, beta polypeptide -4.24528
TM9SF3 transmembrane 9 superfamily member 3 -4.0302
SLC35F2 solute carrier family 35, member F2 -4.00437
STMN1 stathmin 1 -3.88583
PROS1 protein S (alpha) -3.76875
PARP1 poly (ADP-ribose) polymerase 1 -3.73798
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.68662
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.57632
PRPF4 pre-mRNA processing factor 4 -3.47892
LBR lamin B receptor -3.4603
POLR1A polymerase (RNA) I polypeptide A, 194kDa -3.45464
HEATR1 HEAT repeat containing 1 -3.44472
CCNB1 cyclin B1 -3.29235
CDK1 cyclin-dependent kinase 1 -3.27674
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.23215
DNM1L dynamin 1-like -3.23164
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.2114
PGAM4 phosphoglycerate mutase family member 4 -3.11844
CDC25B cell division cycle 25B -3.11019
NLRP2B NLR family pyrin domain containing 2B -3.09864
TLR4 toll-like receptor 4 -3.07942
CCNB2 cyclin B2 -2.89972
GNAS GNAS complex locus -2.8341
HMG20B high mobility group 20B -2.80843
ETFB electron-transfer-flavoprotein, beta polypeptide -2.71771
FAT1 FAT atypical cadherin 1 -2.63572
ISOC1 isochorismatase domain containing 1 -2.6128
MAT2A methionine adenosyltransferase II, alpha -2.57787
GRWD1 glutamate-rich WD repeat containing 1 -2.57216
NT5DC2 5'-nucleotidase domain containing 2 -2.53607
GTF2A2 general transcription factor IIA, 2, 12kDa -2.45136
GET1 guided entry of tail-anchored proteins factor 1 -2.40565
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.40418
MAPK13 mitogen-activated protein kinase 13 -2.39338
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.39072
NISCH nischarin -2.38517
HDAC2 histone deacetylase 2 -2.38004
IL33 interleukin 33 -2.37162
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.35457
THAP11 THAP domain containing 11 -2.35174
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.35135
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.32356
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.26389
AFM afamin -2.25559
S100A9 S100 calcium binding protein A9 -2.24482
ZWINT ZW10 interacting kinetochore protein -2.23004
RPIA ribose 5-phosphate isomerase A -2.22904
TUBB6 tubulin, beta 6 class V -2.21389
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.21339
G6PC1 glucose-6-phosphatase catalytic subunit 1 -2.20855
CCNA2 cyclin A2 -2.2078
PPA2 pyrophosphatase (inorganic) 2 -2.18726
CD63 CD63 molecule -2.16559
TFDP1 transcription factor Dp-1 -2.15463
ZNF711 zinc finger protein 711 -2.15382
BLCAP bladder cancer associated protein -2.14792
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 -2.14313
MYLK myosin light chain kinase -2.12211
SKIC2 SKI2 subunit of superkiller complex -2.11894
CYP3A7-CYP3A51P CYP3A7-CYP3A51P readthrough -2.11762
ATP8B4 ATPase, class I, type 8B, member 4 -2.09935
ITGA1 integrin, alpha 1 -2.09377
RFC2 replication factor C (activator 1) 2, 40kDa -2.07396
NUP210 nucleoporin 210kDa -2.06407
DCPS decapping enzyme, scavenger -2.06076
AGO4 argonaute RISC catalytic component 4 -2.0566
CYB5RL cytochrome b5 reductase-like -2.04109
ATAD5 ATPase family, AAA domain containing 5 -2.03907
ABI3BP ABI family, member 3 (NESH) binding protein -2.02549
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa -2.01989
CHAD chondroadherin -2.01942
NFRKB nuclear factor related to kappaB binding protein -2.01048
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.00763
PECR peroxisomal trans-2-enoyl-CoA reductase -2.00563
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 -2.003