CRCGN014_HEPG2_3H:O09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3'-methyl-4-dimethylaminoazobenzene 49.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

144 genes differentially expressed following the CRCGN014_HEPG2_3H:O09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.62852
SFTPB surfactant protein B 4.88272
MINDY1 MINDY lysine 48 deubiquitinase 1 4.75071
CXCL2 chemokine (C-X-C motif) ligand 2 4.71902
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.57955
CIAO3 cytosolic iron-sulfur assembly component 3 4.43887
BACE2 beta-site APP-cleaving enzyme 2 4.09568
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.91939
STK10 serine/threonine kinase 10 3.68838
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.60314
NT5DC2 5'-nucleotidase domain containing 2 3.58305
CHN1 chimerin 1 3.55239
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 3.542
MUC1 mucin 1, cell surface associated 3.52003
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.49763
AMDHD2 amidohydrolase domain containing 2 3.46255
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.36917
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 3.24829
DDIT4 DNA-damage-inducible transcript 4 3.15445
ANO1 anoctamin 1, calcium activated chloride channel 3.09379
C2CD2 C2 calcium-dependent domain containing 2 3.0778
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.89374
NOSIP nitric oxide synthase interacting protein 2.8284
CHMP6 charged multivesicular body protein 6 2.78778
ZBTB35 zinc finger and BTB domain containing 35 2.74944
TBP TATA box binding protein 2.7465
RRAGA Ras-related GTP binding A 2.69607
LOC122526780 uncharacterized LOC122526780 2.69279
PLAAT4 phospholipase A and acyltransferase 4 2.69124
RAX retina and anterior neural fold homeobox 2.65008
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 2.64226
MEST mesoderm specific transcript 2.61051
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.60785
TSKU tsukushi, small leucine rich proteoglycan 2.56906
TMEM265 transmembrane protein 265 2.55942
TCF12 transcription factor 12 2.54622
BAD BCL2-associated agonist of cell death 2.54504
SYMPK symplekin 2.52096
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.51637
CASC3 cancer susceptibility candidate 3 2.48819
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.46465
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.44935
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.41623
CDC34 cell division cycle 34 2.41599
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.4129
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.40256
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.38377
TBXT T-box transcription factor T 2.36205
PGAM4 phosphoglycerate mutase family member 4 2.35947
PCBP4 poly(rC) binding protein 4 2.33025
SHB Src homology 2 domain containing adaptor protein B 2.3276
RND1 Rho family GTPase 1 2.31978
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.3145
NNT nicotinamide nucleotide transhydrogenase 2.28889
PKN1 protein kinase N1 2.26278
CCDC86 coiled-coil domain containing 86 2.25461
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.2531
GADD45G growth arrest and DNA-damage-inducible, gamma 2.2495
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 2.24788
GRB10 growth factor receptor-bound protein 10 2.23645
CDK6 cyclin-dependent kinase 6 2.19334
SYNGAP1 synaptic Ras GTPase activating protein 1 2.18712
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.17989
PTGDR prostaglandin D2 receptor (DP) 2.16353
NOTCH1 notch 1 2.1567
RSF1 remodeling and spacing factor 1 2.15326
FGF9 fibroblast growth factor 9 2.14566
GPATCH8 G patch domain containing 8 2.13842
SH3BP4 SH3-domain binding protein 4 2.13042
LSR lipolysis stimulated lipoprotein receptor 2.12711
OSBP2 oxysterol binding protein 2 2.10963
MBNL3 muscleblind-like splicing regulator 3 2.10025
WDTC1 WD and tetratricopeptide repeats 1 2.10009
MCHR1 melanin-concentrating hormone receptor 1 2.0957
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 2.0871
H2BC21 H2B clustered histone 21 2.08177
CLASRP CLK4-associating serine/arginine rich protein 2.07353
KLK12 kallikrein-related peptidase 12 2.06953
SLC49A3 solute carrier family 49 member 3 2.06717
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.05822
PITX3 paired-like homeodomain 3 2.05001
UBXN6 UBX domain protein 6 2.03924
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.03769
DIPK1A divergent protein kinase domain 1A 2.02886
ARHGAP12 Rho GTPase activating protein 12 2.0266
NR0B2 nuclear receptor subfamily 0, group B, member 2 2.02007
RXRA retinoid X receptor, alpha 2.00768
SKIC8 SKI8 subunit of superkiller complex 2.00615
PAX9 paired box 9 2.0051
ZNF609 zinc finger protein 609 2.00169

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.42523
SPAG4 sperm associated antigen 4 -4.89462
THAP11 THAP domain containing 11 -4.89216
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.7731
ACOT9 acyl-CoA thioesterase 9 -4.72958
SCAND1 SCAN domain containing 1 -4.66365
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.39993
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -4.33254
CCNH cyclin H -4.28922
PCNA proliferating cell nuclear antigen -4.20982
CCNB1 cyclin B1 -3.90001
CD320 CD320 molecule -3.68565
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.67941
OXA1L oxidase (cytochrome c) assembly 1-like -3.67568
SMNDC1 survival motor neuron domain containing 1 -3.47113
ADI1 acireductone dioxygenase 1 -3.25325
TCTN1 tectonic family member 1 -3.23879
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.22781
SLC35F2 solute carrier family 35, member F2 -3.21256
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.18766
FOS FBJ murine osteosarcoma viral oncogene homolog -2.98897
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.98516
BIRC2 baculoviral IAP repeat containing 2 -2.93176
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.82829
CRYZ crystallin, zeta (quinone reductase) -2.7064
BPHL biphenyl hydrolase-like (serine hydrolase) -2.70591
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.68273
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -2.62224
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.58304
BRCA1 breast cancer 1, early onset -2.54871
TM9SF2 transmembrane 9 superfamily member 2 -2.41072
RWDD2B RWD domain containing 2B -2.40853
EAPP E2F-associated phosphoprotein -2.40469
PRCP prolylcarboxypeptidase (angiotensinase C) -2.40263
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.39161
RBKS ribokinase -2.34543
ITGB1BP1 integrin beta 1 binding protein 1 -2.34311
ENOPH1 enolase-phosphatase 1 -2.24415
MOK MOK protein kinase -2.22076
ZNF586 zinc finger protein 586 -2.18615
ADSS2 adenylosuccinate synthase 2 -2.18157
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.15843
HLA-DMA major histocompatibility complex, class II, DM alpha -2.15653
DNM1L dynamin 1-like -2.14289
GINS4 GINS complex subunit 4 (Sld5 homolog) -2.1422
PECR peroxisomal trans-2-enoyl-CoA reductase -2.09779
MALT1 MALT1 paracaspase -2.09477
L2HGDH L-2-hydroxyglutarate dehydrogenase -2.09259
FBXL12 F-box and leucine-rich repeat protein 12 -2.07242
RWDD2A RWD domain containing 2A -2.07235
TOMM34 translocase of outer mitochondrial membrane 34 -2.05784
MAP7D3 MAP7 domain containing 3 -2.03493
AKAP8 A kinase (PRKA) anchor protein 8 -2.01766
KIF2C kinesin family member 2C -2.00924