CRCGN014_HEPG2_3H:O10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tributyl phosphate 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN014_HEPG2_3H:O10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 7.16197
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.84486
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.32576
LPAR2 lysophosphatidic acid receptor 2 4.31314
DIPK1A divergent protein kinase domain 1A 4.1037
NOTCH1 notch 1 3.42565
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.40534
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.21345
CARMIL1 capping protein regulator and myosin 1 linker 1 3.12563
PNKP polynucleotide kinase 3'-phosphatase 3.05341
HYOU1 hypoxia up-regulated 1 2.97427
CCP110 centriolar coiled coil protein 110kDa 2.91222
FZD7 frizzled class receptor 7 2.88432
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.78445
CHN1 chimerin 1 2.66187
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.53143
SAA2 serum amyloid A2 2.37285
BAG3 BCL2-associated athanogene 3 2.27826
PIH1D1 PIH1 domain containing 1 2.27548
GPATCH8 G patch domain containing 8 2.19949
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.19838
EMC9 ER membrane protein complex subunit 9 2.18194
MAP7 microtubule-associated protein 7 2.1778
STK10 serine/threonine kinase 10 2.0474

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -6.73001
CCNB2 cyclin B2 -6.15592
ZNF586 zinc finger protein 586 -5.22052
GNAS GNAS complex locus -4.98443
ZDHHC6 zinc finger, DHHC-type containing 6 -4.06145
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.71889
PCCB propionyl CoA carboxylase, beta polypeptide -3.63615
ADI1 acireductone dioxygenase 1 -3.13883
TLR4 toll-like receptor 4 -3.05937
NT5DC2 5'-nucleotidase domain containing 2 -2.97355
NGRN neugrin, neurite outgrowth associated -2.97241
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.89378
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.68674
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.58398
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.55772
DERA deoxyribose-phosphate aldolase (putative) -2.55365
PEG10 paternally expressed 10 -2.55207
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.45771
HSPA8 heat shock 70kDa protein 8 -2.40241
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.31958
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.29195
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D -2.25265
ATL2 atlastin GTPase 2 -2.19793
MAPK13 mitogen-activated protein kinase 13 -2.18659
PRPF4 pre-mRNA processing factor 4 -2.18049
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.17303
GRWD1 glutamate-rich WD repeat containing 1 -2.08415
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.00334