CRCGN014_HEPG2_3H:O11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 40.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

191 genes differentially expressed following the CRCGN014_HEPG2_3H:O11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 7.0894
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.02074
AMDHD2 amidohydrolase domain containing 2 6.84677
CHMP6 charged multivesicular body protein 6 4.95196
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.84271
CBR3 carbonyl reductase 3 4.82276
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.79261
BZW2 basic leucine zipper and W2 domains 2 4.71081
PPARG peroxisome proliferator-activated receptor gamma 4.66185
MEST mesoderm specific transcript 4.60353
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.49091
CARMIL1 capping protein regulator and myosin 1 linker 1 3.94818
LPAR2 lysophosphatidic acid receptor 2 3.83237
NT5DC2 5'-nucleotidase domain containing 2 3.79408
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.6594
BAX BCL2-associated X protein 3.51049
ZNF428 zinc finger protein 428 3.36638
POU3F3 POU class 3 homeobox 3 3.29492
MELK maternal embryonic leucine zipper kinase 3.25028
GATA3 GATA binding protein 3 3.04893
ZNF589 zinc finger protein 589 2.95655
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.92932
KIF20A kinesin family member 20A 2.92423
NUP133 nucleoporin 133kDa 2.89885
BRSK2 BR serine/threonine kinase 2 2.83021
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.82097
INHA inhibin, alpha 2.65902
TREH trehalase (brush-border membrane glycoprotein) 2.64819
CCL2 chemokine (C-C motif) ligand 2 2.62344
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.62232
TIAM1 T-cell lymphoma invasion and metastasis 1 2.60677
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.56553
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.51657
WNT7B wingless-type MMTV integration site family, member 7B 2.51592
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 2.51024
S1PR5 sphingosine-1-phosphate receptor 5 2.50869
DIPK1A divergent protein kinase domain 1A 2.49811
UBE2A ubiquitin-conjugating enzyme E2A 2.47785
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.47533
FAAP20 FA core complex associated protein 20 2.459
FBXL8 F-box and leucine-rich repeat protein 8 2.45001
MMP23B matrix metallopeptidase 23B 2.44506
WNT3 wingless-type MMTV integration site family, member 3 2.4434
HOXD10 homeobox D10 2.44075
PLA2G2E phospholipase A2, group IIE 2.43435
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.42059
CANT1 calcium activated nucleotidase 1 2.41571
PRKCG protein kinase C, gamma 2.41507
H4C7 H4 clustered histone 7 2.40737
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.40346
SCRT1 scratch family zinc finger 1 2.40326
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.39958
CMA1 chymase 1, mast cell 2.39523
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 2.39417
TAOK3 TAO kinase 3 2.38616
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.38262
CLCA2 chloride channel accessory 2 2.37176
DGKQ diacylglycerol kinase, theta 110kDa 2.36914
CSH2 chorionic somatomammotropin hormone 2 2.36536
BCL7C B-cell CLL/lymphoma 7C 2.35764
FFAR3 free fatty acid receptor 3 2.33769
MED22 mediator complex subunit 22 2.33524
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 2.31954
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.31211
FOXN1 forkhead box N1 2.30672
MCOLN1 mucolipin 1 2.30526
RXFP3 relaxin/insulin-like family peptide receptor 3 2.29173
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.29132
PCDHA10 protocadherin alpha 10 2.28301
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.27776
CCDC82 coiled-coil domain containing 82 2.2704
MAPK4 mitogen-activated protein kinase 4 2.26592
IVL involucrin 2.26579
DAPK3 death-associated protein kinase 3 2.26532
ZNF274 zinc finger protein 274 2.2646
FAAP100 FA core complex associated protein 100 2.25768
STXBP2 syntaxin binding protein 2 2.25175
GATA2 GATA binding protein 2 2.24765
SIX2 SIX homeobox 2 2.24168
CDX4 caudal type homeobox 4 2.23248
IL36G interleukin 36, gamma 2.23212
ANO1 anoctamin 1, calcium activated chloride channel 2.22866
DENND2B DENN domain containing 2B 2.22703
GIPR gastric inhibitory polypeptide receptor 2.22387
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.21936
TEF thyrotrophic embryonic factor 2.21789
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.21744
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.21193
FOXD3 forkhead box D3 2.18272
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.17108
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.16902
FN3K fructosamine 3 kinase 2.16836
DTX2 deltex 2, E3 ubiquitin ligase 2.16253
SAA2 serum amyloid A2 2.16148
CCL5 chemokine (C-C motif) ligand 5 2.15493
GPR27 G protein-coupled receptor 27 2.1505
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 2.14849
CFAP46 cilia and flagella associated protein 46 2.14069
FAM32A family with sequence similarity 32, member A 2.13014
NOSIP nitric oxide synthase interacting protein 2.12459
XCR1 chemokine (C motif) receptor 1 2.12227
SSTR1 somatostatin receptor 1 2.12008
RCVRN recoverin 2.11801
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.11631
CASC3 cancer susceptibility candidate 3 2.10947
INTS12 integrator complex subunit 12 2.10847
CBR1 carbonyl reductase 1 2.10069
CD247 CD247 molecule 2.09854
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 2.09512
CLN3 ceroid-lipofuscinosis, neuronal 3 2.09242
NNT nicotinamide nucleotide transhydrogenase 2.09107
FOXL1 forkhead box L1 2.09018
OSBP2 oxysterol binding protein 2 2.08984
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.08745
PSG11 pregnancy specific beta-1-glycoprotein 11 2.08281
ARSA arylsulfatase A 2.08028
TMEM223 transmembrane protein 223 2.07502
TEX11 testis expressed 11 2.07193
STX10 syntaxin 10 2.07091
PPP1R37 protein phosphatase 1, regulatory subunit 37 2.06814
DRD3 dopamine receptor D3 2.06351
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.06206
IL26 interleukin 26 2.05766
LOC124907782 dual specificity protein phosphatase 22 2.05548
PLPP3 phospholipid phosphatase 3 2.04995
KHDC1L KH homology domain containing 1-like 2.0485
FABP4 fatty acid binding protein 4, adipocyte 2.0477
HCAR3 hydroxycarboxylic acid receptor 3 2.04643
COPS4 COP9 signalosome subunit 4 2.04161
IL1A interleukin 1, alpha 2.03982
SPINK5 serine peptidase inhibitor, Kazal type 5 2.02559
FGF8 fibroblast growth factor 8 (androgen-induced) 2.0254
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.02006
NEUROG3 neurogenin 3 2.01955
LRTM1 leucine-rich repeats and transmembrane domains 1 2.01852
TNNI1 troponin I type 1 (skeletal, slow) 2.01613
AIM2 absent in melanoma 2 2.01551
CLDN15 claudin 15 2.0155
EMC6 ER membrane protein complex subunit 6 2.0129
STMN3 stathmin-like 3 2.01283
CTSW cathepsin W 2.00611
OVOL3 ovo-like zinc finger 3 2.00298
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 2.00252

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -6.67724
ADI1 acireductone dioxygenase 1 -6.4604
OXA1L oxidase (cytochrome c) assembly 1-like -6.11918
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.98234
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.97147
PCNA proliferating cell nuclear antigen -4.79838
PRPF4 pre-mRNA processing factor 4 -4.41288
RPN1 ribophorin I -4.39829
CD320 CD320 molecule -4.2591
ACAA1 acetyl-CoA acyltransferase 1 -4.0423
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.76459
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.53163
GNAS GNAS complex locus -3.46686
DCK deoxycytidine kinase -3.44023
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.36229
CAB39 calcium binding protein 39 -3.34184
SNX11 sorting nexin 11 -3.13015
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.1025
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.06664
SQOR sulfide quinone oxidoreductase -2.85191
MTA1 metastasis associated 1 -2.76988
TXNDC9 thioredoxin domain containing 9 -2.7486
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.61091
MYL9 myosin, light chain 9, regulatory -2.57643
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.56163
USP22 ubiquitin specific peptidase 22 -2.53766
PECR peroxisomal trans-2-enoyl-CoA reductase -2.47476
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.40568
LEMD3 LEM domain containing 3 -2.40408
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.35038
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.30394
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -2.24325
CRYZ crystallin, zeta (quinone reductase) -2.21612
TCTN1 tectonic family member 1 -2.1928
TM9SF2 transmembrane 9 superfamily member 2 -2.18152
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.16913
FOS FBJ murine osteosarcoma viral oncogene homolog -2.13682
STAG3 stromal antigen 3 -2.09836
THAP11 THAP domain containing 11 -2.09045
GTF2H5 general transcription factor IIH, polypeptide 5 -2.07503
SNF8 SNF8, ESCRT-II complex subunit -2.07287
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.07249
HSPE1 heat shock 10kDa protein 1 -2.05467
FCHO1 FCH domain only 1 -2.03842
TAOK1 TAO kinase 1 -2.03349
WASHC4 WASH complex subunit 4 -2.03306
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -2.01688
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -2.00381