CRCGN014_HEPG2_3H:O12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(4-aminobenzyl)phenylamine 20.17 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN014_HEPG2_3H:O12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 4.42661
PLSCR3 phospholipid scramblase 3 4.37084
CIAO3 cytosolic iron-sulfur assembly component 3 4.30716
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.12032
UBQLN2 ubiquilin 2 3.95183
STIMATE STIM activating enhancer 3.77737
HPRT1 hypoxanthine phosphoribosyltransferase 1 3.63224
RPL39L ribosomal protein L39-like 3.59688
GPER1 G protein-coupled estrogen receptor 1 3.43548
STK10 serine/threonine kinase 10 3.35939
SFTPB surfactant protein B 3.33737
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.01431
CXCL2 chemokine (C-X-C motif) ligand 2 2.9709
SNAP25 synaptosomal-associated protein, 25kDa 2.9151
SEC31B SEC31 homolog B (S. cerevisiae) 2.59412
KLHL9 kelch-like family member 9 2.52494
TIAM1 T-cell lymphoma invasion and metastasis 1 2.50797
LCN2 lipocalin 2 2.47004
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.46575
TPD52L2 tumor protein D52-like 2 2.4445
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.43116
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.42094
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.40294
TREM1 triggering receptor expressed on myeloid cells 1 2.36477
HOOK3 hook microtubule-tethering protein 3 2.27333
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.22183
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.08613
NME4 NME/NM23 nucleoside diphosphate kinase 4 2.06939
FDXR ferredoxin reductase 2.05107
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.0159
GATA2 GATA binding protein 2 2.00615

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.7598
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.23963
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.63506
PEG10 paternally expressed 10 -4.47323
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.39548
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.34629
CDC20 cell division cycle 20 -4.271
LDHD lactate dehydrogenase D -4.10416
TRIB3 tribbles pseudokinase 3 -4.02681
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.74877
YME1L1 YME1-like 1 ATPase -3.68684
GNAS GNAS complex locus -3.237
CCNB2 cyclin B2 -3.14631
MTA1 metastasis associated 1 -2.71238
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.51973
DCK deoxycytidine kinase -2.2778
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.19135
RNF167 ring finger protein 167 -2.1574
NGRN neugrin, neurite outgrowth associated -2.15258
GALE UDP-galactose-4-epimerase -2.06888