CRCGN014_HEPG2_3H:O15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitrosoethylmethylamine 39.4 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN014_HEPG2_3H:O15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 4.80599
CCDC92 coiled-coil domain containing 92 4.2712
GPER1 G protein-coupled estrogen receptor 1 3.94418
EVL Enah/Vasp-like 3.61307
UBQLN2 ubiquilin 2 3.5267
PRKCD protein kinase C, delta 3.47576
ABHD6 abhydrolase domain containing 6 3.31801
PPARG peroxisome proliferator-activated receptor gamma 2.94724
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.873
KLHL21 kelch-like family member 21 2.84096
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.79303
MINDY1 MINDY lysine 48 deubiquitinase 1 2.65764
ZBTB18 zinc finger and BTB domain containing 18 2.53757
MAP7 microtubule-associated protein 7 2.45899
DYNLT3 dynein, light chain, Tctex-type 3 2.44689
CCL2 chemokine (C-C motif) ligand 2 2.4322
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.40012
CXCL2 chemokine (C-X-C motif) ligand 2 2.34438
VGLL4 vestigial-like family member 4 2.23432
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.23258
SGPP1 sphingosine-1-phosphate phosphatase 1 2.19412
FZD7 frizzled class receptor 7 2.17636
WFS1 Wolfram syndrome 1 (wolframin) 2.12591
ZNF589 zinc finger protein 589 2.03241
CYCS cytochrome c, somatic 2.0239
SNX7 sorting nexin 7 2.01968
DIPK1A divergent protein kinase domain 1A 2.00668

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.06386
OXA1L oxidase (cytochrome c) assembly 1-like -3.5904
ZNF586 zinc finger protein 586 -3.48353
PCNA proliferating cell nuclear antigen -3.31091
MAPK13 mitogen-activated protein kinase 13 -3.29897
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.15208
LDHD lactate dehydrogenase D -3.00234
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.61823
WASHC4 WASH complex subunit 4 -2.56802
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.55621
CHMP4B charged multivesicular body protein 4B -2.41089
SNX11 sorting nexin 11 -2.36558
EIF5 eukaryotic translation initiation factor 5 -2.33166
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.28414
GNAS GNAS complex locus -2.26753
HMG20B high mobility group 20B -2.18704
TXNDC9 thioredoxin domain containing 9 -2.1449
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.13075
RNF167 ring finger protein 167 -2.06524
MDH1 malate dehydrogenase 1, NAD (soluble) -2.01135