CRCGN014_HEPG2_3H:O18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methyl-2-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy]propanoic acid 21.26 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN014_HEPG2_3H:O18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CBR3 carbonyl reductase 3 4.57308
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.55838
E2F2 E2F transcription factor 2 4.27639
CXCL2 chemokine (C-X-C motif) ligand 2 4.14864
CYCS cytochrome c, somatic 3.53063
MAP7 microtubule-associated protein 7 3.3118
TEX10 testis expressed 10 2.88736
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.84341
STIMATE STIM activating enhancer 2.77583
UBQLN2 ubiquilin 2 2.52756
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.50866
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.30458
VGLL4 vestigial-like family member 4 2.29825
TREM1 triggering receptor expressed on myeloid cells 1 2.25288
RSAD2 radical S-adenosyl methionine domain containing 2 2.23179
AMDHD2 amidohydrolase domain containing 2 2.13897
AXIN1 axin 1 2.12014
NFIL3 nuclear factor, interleukin 3 regulated 2.09502
IFI6 interferon, alpha-inducible protein 6 2.07502
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.06548
ANO1 anoctamin 1, calcium activated chloride channel 2.03048
GPER1 G protein-coupled estrogen receptor 1 2.02188

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.04782
TRIB3 tribbles pseudokinase 3 -4.64886
MAPK13 mitogen-activated protein kinase 13 -4.06945
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.97534
MTA1 metastasis associated 1 -2.91078
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.75256
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.57729
NGRN neugrin, neurite outgrowth associated -2.57564
HSPB1 heat shock 27kDa protein 1 -2.49798
TXNDC9 thioredoxin domain containing 9 -2.34032
CSK c-src tyrosine kinase -2.2959
MYL9 myosin, light chain 9, regulatory -2.17246
CHMP4B charged multivesicular body protein 4B -2.15048
REEP5 receptor accessory protein 5 -2.13073
EIF5 eukaryotic translation initiation factor 5 -2.10278
NT5DC2 5'-nucleotidase domain containing 2 -2.02467