| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | phenyl-b-naphthylamine 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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81 genes differentially expressed following the CRCGN014_HEPG2_3H:O19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDIT4 | DNA-damage-inducible transcript 4 | 8.48794 |
| EGR1 | early growth response 1 | 4.47657 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 4.3442 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 4.20972 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 3.96716 |
| ADRB2 | adrenoceptor beta 2, surface | 3.81472 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.602 |
| TRIB3 | tribbles pseudokinase 3 | 3.49608 |
| HYOU1 | hypoxia up-regulated 1 | 3.47381 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 3.47213 |
| AARS1 | alanyl-tRNA synthetase 1 | 3.24809 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.12133 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 3.08115 |
| FCHO1 | FCH domain only 1 | 2.98534 |
| DUSP6 | dual specificity phosphatase 6 | 2.93203 |
| IER3 | immediate early response 3 | 2.92614 |
| KDM3A | lysine (K)-specific demethylase 3A | 2.81374 |
| SQSTM1 | sequestosome 1 | 2.78225 |
| LOC128125814 | uncharacterized LOC128125814 | 2.69473 |
| TRIB1 | tribbles pseudokinase 1 | 2.6607 |
| MYLK | myosin light chain kinase | 2.62303 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 2.57529 |
| CYCS | cytochrome c, somatic | 2.54772 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 2.53766 |
| TERT | telomerase reverse transcriptase | 2.53087 |
| MAP7 | microtubule-associated protein 7 | 2.4836 |
| MNT | MAX network transcriptional repressor | 2.4506 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.4368 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 2.42971 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.41995 |
| HDGFL3 | HDGF like 3 | 2.35967 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 2.34148 |
| GOLT1B | golgi transport 1B | 2.31632 |
| FOSL1 | FOS-like antigen 1 | 2.27851 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2.26805 |
| DIPK1A | divergent protein kinase domain 1A | 2.25203 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.244 |
| ICAM1 | intercellular adhesion molecule 1 | 2.1929 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | 2.18929 |
| NUP133 | nucleoporin 133kDa | 2.15291 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 2.14697 |
| SCFD1 | sec1 family domain containing 1 | 2.09383 |
| FOXJ3 | forkhead box J3 | 2.06039 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDC20 | cell division cycle 20 | -7.26535 |
| FASTKD5 | FAST kinase domains 5 | -5.10321 |
| RPIA | ribose 5-phosphate isomerase A | -4.49131 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -4.42791 |
| NGRN | neugrin, neurite outgrowth associated | -4.21062 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -4.03895 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -3.93858 |
| LAP3 | leucine aminopeptidase 3 | -3.62049 |
| CCNB1 | cyclin B1 | -3.51492 |
| PCNA | proliferating cell nuclear antigen | -3.43271 |
| DERA | deoxyribose-phosphate aldolase (putative) | -3.29679 |
| CCNB2 | cyclin B2 | -3.19009 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.12579 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.12404 |
| HAT1 | histone acetyltransferase 1 | -3.10969 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.09482 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.06687 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -2.99937 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -2.95064 |
| DCK | deoxycytidine kinase | -2.88763 |
| GNAS | GNAS complex locus | -2.8287 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.67019 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.59852 |
| CSK | c-src tyrosine kinase | -2.5936 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.55148 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -2.47039 |
| CAB39 | calcium binding protein 39 | -2.41799 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.41169 |
| PRPF4 | pre-mRNA processing factor 4 | -2.40957 |
| THAP11 | THAP domain containing 11 | -2.40854 |
| TRIP13 | thyroid hormone receptor interactor 13 | -2.25297 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.23451 |
| HSPA8 | heat shock 70kDa protein 8 | -2.21822 |
| HMG20B | high mobility group 20B | -2.19219 |
| HMGA2 | high mobility group AT-hook 2 | -2.16946 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -2.126 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -2.05151 |
| ICAM3 | intercellular adhesion molecule 3 | -2.03117 |
