CRCGN014_HEPG2_3H:O20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5,7-dichloro-4-(4-fluorophenoxy)quinoline 21.42 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

83 genes differentially expressed following the CRCGN014_HEPG2_3H:O20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 8.75589
EGR1 early growth response 1 6.46646
TRIB3 tribbles pseudokinase 3 5.66833
TRIB1 tribbles pseudokinase 1 5.43078
STIMATE STIM activating enhancer 5.36245
IER3 immediate early response 3 4.80041
CCP110 centriolar coiled coil protein 110kDa 4.67923
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.30516
ANO1 anoctamin 1, calcium activated chloride channel 4.02635
FOSL1 FOS-like antigen 1 4.02166
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.00322
IL4R interleukin 4 receptor 3.98049
CNPY3 canopy FGF signaling regulator 3 3.59784
GPATCH8 G patch domain containing 8 3.59069
CIAO3 cytosolic iron-sulfur assembly component 3 3.53835
LSR lipolysis stimulated lipoprotein receptor 3.53429
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.53068
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 3.5084
AXIN1 axin 1 3.36785
DUSP6 dual specificity phosphatase 6 3.24769
UBQLN2 ubiquilin 2 3.19399
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.07301
CXCL2 chemokine (C-X-C motif) ligand 2 3.0498
HYOU1 hypoxia up-regulated 1 3.03625
CXCR4 chemokine (C-X-C motif) receptor 4 2.86692
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.81169
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.81144
UFM1 ubiquitin-fold modifier 1 2.80755
MAP7 microtubule-associated protein 7 2.78825
NOTCH1 notch 1 2.73369
INPP1 inositol polyphosphate-1-phosphatase 2.70953
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.5836
C2CD2 C2 calcium-dependent domain containing 2 2.56303
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.46497
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.45954
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.43928
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.39486
RBM15B RNA binding motif protein 15B 2.35348
ADAT1 adenosine deaminase, tRNA-specific 1 2.33591
LOC128125814 uncharacterized LOC128125814 2.32988
PTS 6-pyruvoyltetrahydropterin synthase 2.28102
LPAR2 lysophosphatidic acid receptor 2 2.2783
EPHA2 EPH receptor A2 2.27782
IER2 immediate early response 2 2.24377
ICAM1 intercellular adhesion molecule 1 2.21797
TERF2IP telomeric repeat binding factor 2, interacting protein 2.17866
PDGFA platelet-derived growth factor alpha polypeptide 2.16411
KCTD13 potassium channel tetramerization domain containing 13 2.12447
ZFP36 ZFP36 ring finger protein 2.10458
GOLT1B golgi transport 1B 2.08961
FDX1 ferredoxin 1 2.07287
BCR breakpoint cluster region 2.02058
ATF3 activating transcription factor 3 2.01599
SQSTM1 sequestosome 1 2.00689

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.76576
ZNF586 zinc finger protein 586 -5.69393
CDC25B cell division cycle 25B -4.61622
PCNA proliferating cell nuclear antigen -4.20724
FASTKD5 FAST kinase domains 5 -4.17203
PSRC1 proline/serine-rich coiled-coil 1 -3.90274
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.57629
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.38656
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.35146
OXA1L oxidase (cytochrome c) assembly 1-like -3.1664
TLR4 toll-like receptor 4 -3.11785
CCNB1 cyclin B1 -2.94561
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.72862
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.51548
NRIP1 nuclear receptor interacting protein 1 -2.371
THAP11 THAP domain containing 11 -2.323
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.31474
COG2 component of oligomeric golgi complex 2 -2.22809
MALT1 MALT1 paracaspase -2.22306
PGAM4 phosphoglycerate mutase family member 4 -2.20091
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.19218
CDC20 cell division cycle 20 -2.1653
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.08438
CCDC25 coiled-coil domain containing 25 -2.07904
NLRP2B NLR family pyrin domain containing 2B -2.06786
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.06553
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.02805
NUP62 nucleoporin 62kDa -2.02778
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.00376