CRCGN014_HEPG2_3H:O24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN014_HEPG2_3H:O24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.17114
MEF2C myocyte enhancer factor 2C 3.61411
TIAM1 T-cell lymphoma invasion and metastasis 1 3.57913
SFTPB surfactant protein B 3.44124
IFI44L interferon-induced protein 44-like 3.4031
KLHL9 kelch-like family member 9 3.12542
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.11188
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.10419
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3.08111
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.07393
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 3.06706
XAF1 XIAP associated factor 1 2.88524
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.87787
RRAGA Ras-related GTP binding A 2.81364
MOK MOK protein kinase 2.65201
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.60335
DIPK1A divergent protein kinase domain 1A 2.54125
HOXA10 homeobox A10 2.48863
KIF14 kinesin family member 14 2.47094
MBNL1 muscleblind-like splicing regulator 1 2.43707
MX1 MX dynamin-like GTPase 1 2.39912
MYBPC1 myosin binding protein C, slow type 2.39412
RSAD2 radical S-adenosyl methionine domain containing 2 2.37611
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.34023
TRIM21 tripartite motif containing 21 2.29416
ISG15 ISG15 ubiquitin-like modifier 2.23182
IFI44 interferon-induced protein 44 2.2302
DMTF1 cyclin D binding myb-like transcription factor 1 2.22003
CYBRD1 cytochrome b reductase 1 2.21537
OTUD3 OTU deubiquitinase 3 2.17612
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 2.15684
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.13476
MTTP microsomal triglyceride transfer protein 2.07413
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.0417
CTTN cortactin 2.02237
SNAP25 synaptosomal-associated protein, 25kDa 2.02166
ADAR adenosine deaminase, RNA-specific 2.02114

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.10346
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.30591
PCCB propionyl CoA carboxylase, beta polypeptide -5.29966
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -5.13588
CDC20 cell division cycle 20 -5.0278
LDHD lactate dehydrogenase D -4.69712
FAIM Fas apoptotic inhibitory molecule -4.59094
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.63892
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.4786
OXA1L oxidase (cytochrome c) assembly 1-like -3.31941
CSK c-src tyrosine kinase -3.30616
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.2419
UBE3C ubiquitin protein ligase E3C -3.00038
GRB7 growth factor receptor-bound protein 7 -2.66296
BPHL biphenyl hydrolase-like (serine hydrolase) -2.61225
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.5074
SOAT2 sterol O-acyltransferase 2 -2.45565
AKAP8 A kinase (PRKA) anchor protein 8 -2.25245
TCEAL4 transcription elongation factor A (SII)-like 4 -2.14707
GNAS GNAS complex locus -2.0207