| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | geldanamycin 20.0 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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114 genes differentially expressed following the CRCGN014_HEPG2_3H:P01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDIT4 | DNA-damage-inducible transcript 4 | 10.0 |
| HSPA1A | heat shock 70kDa protein 1A | 10.0 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 6.63051 |
| ADRB2 | adrenoceptor beta 2, surface | 6.367 |
| BAG3 | BCL2-associated athanogene 3 | 6.01596 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 5.71557 |
| CBR3 | carbonyl reductase 3 | 5.12665 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 4.90278 |
| CYCS | cytochrome c, somatic | 4.38262 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 4.35553 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 4.28442 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 4.13121 |
| AARS1 | alanyl-tRNA synthetase 1 | 4.10042 |
| HYOU1 | hypoxia up-regulated 1 | 4.01812 |
| SFTPB | surfactant protein B | 4.01373 |
| HSPA1B | heat shock 70kDa protein 1B | 3.88925 |
| RPL39L | ribosomal protein L39-like | 3.5989 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.52863 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 3.50301 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.33853 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 3.24301 |
| HSPB1 | heat shock 27kDa protein 1 | 2.9869 |
| NUCB2 | nucleobindin 2 | 2.8984 |
| EVL | Enah/Vasp-like | 2.78148 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.70248 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 2.69333 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 2.66068 |
| ABHD4 | abhydrolase domain containing 4 | 2.59092 |
| LCN2 | lipocalin 2 | 2.58053 |
| EPN2 | epsin 2 | 2.57366 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 2.57239 |
| PRKCH | protein kinase C, eta | 2.52959 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.4822 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 2.45459 |
| PLS1 | plastin 1 | 2.44525 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.43968 |
| NEK7 | NIMA-related kinase 7 | 2.39096 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 2.37833 |
| PCDHB11 | protocadherin beta 11 | 2.32775 |
| P2RY2 | purinergic receptor P2Y, G-protein coupled, 2 | 2.30914 |
| CDK7 | cyclin-dependent kinase 7 | 2.29668 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 2.28506 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 2.26678 |
| UFM1 | ubiquitin-fold modifier 1 | 2.24329 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 2.21452 |
| MEST | mesoderm specific transcript | 2.19305 |
| CASC3 | cancer susceptibility candidate 3 | 2.19071 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.18674 |
| TES | testin LIM domain protein | 2.16532 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 2.13402 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | 2.12398 |
| EGR1 | early growth response 1 | 2.10794 |
| ICAM1 | intercellular adhesion molecule 1 | 2.09601 |
| ITPKC | inositol-trisphosphate 3-kinase C | 2.08694 |
| BHMT2 | betaine--homocysteine S-methyltransferase 2 | 2.06514 |
| RUBCN | rubicon autophagy regulator | 2.04024 |
| CREB1 | cAMP responsive element binding protein 1 | 2.03377 |
| LOC128125814 | uncharacterized LOC128125814 | 2.02573 |
| TBC1D10C | TBC1 domain family, member 10C | 2.02493 |
| XPOT | exportin, tRNA | 2.00995 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | -7.12623 |
| FASTKD5 | FAST kinase domains 5 | -6.7803 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -6.03419 |
| CAB39 | calcium binding protein 39 | -4.97099 |
| CDC20 | cell division cycle 20 | -4.81624 |
| LAP3 | leucine aminopeptidase 3 | -4.01222 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -3.99898 |
| HAT1 | histone acetyltransferase 1 | -3.886 |
| ADI1 | acireductone dioxygenase 1 | -3.8399 |
| PROS1 | protein S (alpha) | -3.72921 |
| ZNF586 | zinc finger protein 586 | -3.61926 |
| CCDC86 | coiled-coil domain containing 86 | -3.46408 |
| LDHD | lactate dehydrogenase D | -3.44028 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.33315 |
| CCNH | cyclin H | -3.24372 |
| SCAND1 | SCAN domain containing 1 | -3.11031 |
| TERT | telomerase reverse transcriptase | -3.08432 |
| SOAT2 | sterol O-acyltransferase 2 | -3.07285 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -2.99623 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.98357 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.81215 |
| CDC25B | cell division cycle 25B | -2.75007 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | -2.72526 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.68806 |
| ELAC2 | elaC ribonuclease Z 2 | -2.67647 |
| COG7 | component of oligomeric golgi complex 7 | -2.66806 |
| GNAS | GNAS complex locus | -2.55772 |
| ACOT9 | acyl-CoA thioesterase 9 | -2.52719 |
| AGBL5 | ATP/GTP binding protein-like 5 | -2.48315 |
| PLCXD1 | phosphatidylinositol-specific phospholipase C, X domain containing 1 | -2.48207 |
| PLK1 | polo-like kinase 1 | -2.447 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.39256 |
| TRAP1 | TNF receptor-associated protein 1 | -2.33903 |
| TBC1D31 | TBC1 domain family, member 31 | -2.33534 |
| CDK4 | cyclin-dependent kinase 4 | -2.33092 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -2.33025 |
| NOP56 | NOP56 ribonucleoprotein | -2.32543 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -2.27366 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.24142 |
| PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | -2.20307 |
| CHEK1 | checkpoint kinase 1 | -2.20031 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -2.15616 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.1434 |
| EMC8 | ER membrane protein complex subunit 8 | -2.13109 |
| THAP11 | THAP domain containing 11 | -2.11517 |
| TMEM230 | transmembrane protein 230 | -2.1128 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -2.11116 |
| DCK | deoxycytidine kinase | -2.10821 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -2.07599 |
| ATAD5 | ATPase family, AAA domain containing 5 | -2.06174 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | -2.04409 |
| FAIM | Fas apoptotic inhibitory molecule | -2.03114 |
| EFHD2 | EF-hand domain family, member D2 | -2.02939 |
| MSH6 | mutS homolog 6 | -2.0016 |
