| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | disulfiram 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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209 genes differentially expressed following the CRCGN014_HEPG2_3H:P04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDIT4 | DNA-damage-inducible transcript 4 | 10.0 |
| HSPA1A | heat shock 70kDa protein 1A | 9.99222 |
| BAG3 | BCL2-associated athanogene 3 | 9.51497 |
| EGR1 | early growth response 1 | 7.5339 |
| HMOX1 | heme oxygenase 1 | 7.04088 |
| UBQLN2 | ubiquilin 2 | 6.59838 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 6.44568 |
| FOSL1 | FOS-like antigen 1 | 6.00919 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 5.79368 |
| FRS2 | fibroblast growth factor receptor substrate 2 | 5.28295 |
| JUN | jun proto-oncogene | 4.88432 |
| H2BC12 | H2B clustered histone 12 | 4.73912 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 4.58675 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 4.52338 |
| HSPA1B | heat shock 70kDa protein 1B | 4.46924 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 4.37432 |
| KIFBP | kinesin family binding protein | 4.2986 |
| LPAR2 | lysophosphatidic acid receptor 2 | 3.71536 |
| CDK7 | cyclin-dependent kinase 7 | 3.67274 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 3.64458 |
| CCNF | cyclin F | 3.64059 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 3.5758 |
| NOTCH1 | notch 1 | 3.54935 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 3.50596 |
| PNKP | polynucleotide kinase 3'-phosphatase | 3.4729 |
| IER2 | immediate early response 2 | 3.3375 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 3.32569 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.31131 |
| JMJD6 | jumonji domain containing 6 | 3.11661 |
| ANKRD10 | ankyrin repeat domain 10 | 3.08335 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 3.07843 |
| CNPY3 | canopy FGF signaling regulator 3 | 3.07031 |
| EVL | Enah/Vasp-like | 3.06772 |
| USPL1 | ubiquitin specific peptidase like 1 | 3.05195 |
| KDM3A | lysine (K)-specific demethylase 3A | 3.01539 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 3.0072 |
| RNMT | RNA (guanine-7-) methyltransferase | 2.97525 |
| ZFP36 | ZFP36 ring finger protein | 2.81241 |
| PTK2 | protein tyrosine kinase 2 | 2.78215 |
| HSPB1 | heat shock 27kDa protein 1 | 2.76824 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.76604 |
| KIF20A | kinesin family member 20A | 2.73281 |
| LOC128125814 | uncharacterized LOC128125814 | 2.71043 |
| TBP | TATA box binding protein | 2.62553 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.58992 |
| PLS1 | plastin 1 | 2.5769 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 2.5573 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 2.52879 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 2.52464 |
| DNM1L | dynamin 1-like | 2.51005 |
| NUP58 | nucleoporin 58 | 2.49331 |
| CYCS | cytochrome c, somatic | 2.48934 |
| BBC3 | BCL2 binding component 3 | 2.46798 |
| ATF3 | activating transcription factor 3 | 2.45797 |
| ZNF12 | zinc finger protein 12 | 2.45386 |
| TRIB1 | tribbles pseudokinase 1 | 2.4429 |
| FOXJ3 | forkhead box J3 | 2.43985 |
| SKIC8 | SKI8 subunit of superkiller complex | 2.43418 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 2.42944 |
| SNX7 | sorting nexin 7 | 2.42825 |
| CDK6 | cyclin-dependent kinase 6 | 2.40356 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.4023 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 2.37447 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 2.3724 |
| GTF2B | general transcription factor IIB | 2.36616 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 2.36367 |
| EFL1 | elongation factor like GTPase 1 | 2.32743 |
| IER5 | immediate early response 5 | 2.30938 |
| EGR3 | early growth response 3 | 2.29716 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 2.28131 |
| TCF15 | transcription factor 15 (basic helix-loop-helix) | 2.26557 |
| C1QA | complement component 1, q subcomponent, A chain | 2.26294 |
| PLK3 | polo-like kinase 3 | 2.23641 |
| COL4A1 | collagen, type IV, alpha 1 | 2.23263 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 2.22659 |
| CEP76 | centrosomal protein 76kDa | 2.2054 |
| SNAPC2 | small nuclear RNA activating complex, polypeptide 2, 45kDa | 2.1857 |
| DIPK1A | divergent protein kinase domain 1A | 2.18527 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 2.1821 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.1706 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.16897 |
| BZW2 | basic leucine zipper and W2 domains 2 | 2.16624 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 2.14052 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 2.12804 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.12609 |
| DUSP2 | dual specificity phosphatase 2 | 2.11141 |
| TRAF6 | TNF receptor-associated factor 6, E3 ubiquitin protein ligase | 2.10972 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 2.10723 |
| NRBP1 | nuclear receptor binding protein 1 | 2.10024 |
| GUSB | glucuronidase, beta | 2.09628 |
| CLK3 | CDC-like kinase 3 | 2.08897 |
| KDM7A | lysine (K)-specific demethylase 7A | 2.08885 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | 2.07141 |
| PRKCG | protein kinase C, gamma | 2.05797 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 2.05618 |
| RALGDS | ral guanine nucleotide dissociation stimulator | 2.05327 |
| CDC42EP4 | CDC42 effector protein (Rho GTPase binding) 4 | 2.04313 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 2.04262 |
| IFRD1 | interferon-related developmental regulator 1 | 2.03896 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 2.03368 |
| TSC22D3 | TSC22 domain family, member 3 | 2.03229 |
| SIRT1 | sirtuin 1 | 2.02558 |
| ZNF202 | zinc finger protein 202 | 2.025 |
| HINFP | histone H4 transcription factor | 2.02293 |
| ALKBH1 | alkB, alkylation repair homolog 1 (E. coli) | 2.01174 |
| ILK | integrin-linked kinase | 2.00074 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -6.23083 |
| COG7 | component of oligomeric golgi complex 7 | -5.87421 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -5.69241 |
| ADI1 | acireductone dioxygenase 1 | -5.2736 |
| HAT1 | histone acetyltransferase 1 | -4.90615 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -4.79256 |
| GLOD4 | glyoxalase domain containing 4 | -4.29333 |
| TRAP1 | TNF receptor-associated protein 1 | -4.12949 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -3.84184 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.83144 |
| VAT1 | vesicle amine transport 1 | -3.76466 |
| GOLT1B | golgi transport 1B | -3.64356 |
| SLC35F2 | solute carrier family 35, member F2 | -3.55723 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -3.54326 |
| UGDH | UDP-glucose 6-dehydrogenase | -3.49697 |
| SNX11 | sorting nexin 11 | -3.42321 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -3.38253 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -3.36034 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -3.20394 |
| ANXA7 | annexin A7 | -3.1779 |
| MRPS16 | mitochondrial ribosomal protein S16 | -3.14703 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -3.11864 |
| GNAS | GNAS complex locus | -3.09037 |
| TXNDC9 | thioredoxin domain containing 9 | -3.00024 |
| BOLA2B | bolA family member 2B | -2.90512 |
| CRYZ | crystallin, zeta (quinone reductase) | -2.90417 |
| CCNB1 | cyclin B1 | -2.88184 |
| PAGR1 | PAXIP1 associated glutamate-rich protein 1 | -2.84443 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.80393 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.77802 |
| LBR | lamin B receptor | -2.77773 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -2.76025 |
| ZDHHC24 | zinc finger, DHHC-type containing 24 | -2.75733 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -2.72387 |
| CD58 | CD58 molecule | -2.70486 |
| PRCP | prolylcarboxypeptidase (angiotensinase C) | -2.67188 |
| NUP85 | nucleoporin 85kDa | -2.66625 |
| BLCAP | bladder cancer associated protein | -2.6205 |
| SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | -2.60419 |
| OR10H1 | olfactory receptor, family 10, subfamily H, member 1 | -2.58764 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.55134 |
| SEMA6D | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | -2.54846 |
| BRCA1 | breast cancer 1, early onset | -2.53581 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -2.53058 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -2.52162 |
| LAGE3 | L antigen family, member 3 | -2.51156 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -2.50343 |
| STUM | stum, mechanosensory transduction mediator homolog | -2.49068 |
| ATP5ME | ATP synthase membrane subunit e | -2.45863 |
| HMGA2 | high mobility group AT-hook 2 | -2.4299 |
| TBC1D31 | TBC1 domain family, member 31 | -2.42612 |
| BLOC1S1 | biogenesis of lysosomal organelles complex-1, subunit 1 | -2.41429 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | -2.41353 |
| LOC112694756 | uncharaterized LOC112694756 | -2.41316 |
| USP22 | ubiquitin specific peptidase 22 | -2.39722 |
| LSM3 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.39385 |
| MRPL30 | mitochondrial ribosomal protein L30 | -2.37644 |
| GNL1 | guanine nucleotide binding protein-like 1 | -2.36874 |
| CDC20 | cell division cycle 20 | -2.34862 |
| FAAP24 | FA core complex associated protein 24 | -2.34704 |
| SPAG4 | sperm associated antigen 4 | -2.3437 |
| TRAIP | TRAF interacting protein | -2.32111 |
| TMEM50A | transmembrane protein 50A | -2.31719 |
| TSPAN4 | tetraspanin 4 | -2.29653 |
| TFDP1 | transcription factor Dp-1 | -2.28386 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -2.26676 |
| PRPF4 | pre-mRNA processing factor 4 | -2.23576 |
| CDC25B | cell division cycle 25B | -2.20626 |
| GET1 | guided entry of tail-anchored proteins factor 1 | -2.19783 |
| SCAND1 | SCAN domain containing 1 | -2.1832 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -2.17913 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | -2.16645 |
| P3H4 | prolyl 3-hydroxylase family member 4 (non-enzymatic) | -2.14751 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -2.14727 |
| METTL9 | methyltransferase like 9 | -2.14456 |
| SYNDIG1 | synapse differentiation inducing 1 | -2.1419 |
| MALT1 | MALT1 paracaspase | -2.14168 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | -2.12609 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | -2.1223 |
| KRT3 | keratin 3, type II | -2.12151 |
| TCTN1 | tectonic family member 1 | -2.10127 |
| FAIM | Fas apoptotic inhibitory molecule | -2.09406 |
| NAV2 | neuron navigator 2 | -2.08188 |
| COX17 | COX17 cytochrome c oxidase copper chaperone | -2.07536 |
| ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | -2.06884 |
| CDH22 | cadherin 22, type 2 | -2.06458 |
| DIP2A | DIP2 disco-interacting protein 2 homolog A (Drosophila) | -2.05988 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -2.05909 |
| G6PC2 | glucose-6-phosphatase, catalytic, 2 | -2.05862 |
| WNT16 | wingless-type MMTV integration site family, member 16 | -2.05839 |
| ODAD2 | outer dynein arm docking complex subunit 2 | -2.05305 |
| ENY2 | enhancer of yellow 2 homolog (Drosophila) | -2.0456 |
| OR1F1 | olfactory receptor, family 1, subfamily F, member 1 | -2.03764 |
| SCCPDH | saccharopine dehydrogenase (putative) | -2.03446 |
| ELAC2 | elaC ribonuclease Z 2 | -2.02759 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -2.02159 |
| PNPO | pyridoxamine 5'-phosphate oxidase | -2.01813 |
| PRR11 | proline rich 11 | -2.01813 |
| DNMT3B | DNA (cytosine-5-)-methyltransferase 3 beta | -2.01348 |
| PRAMEF10 | PRAME family member 10 | -2.01323 |
| SLC9A8 | solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 | -2.00931 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.00905 |
| DSG2 | desmoglein 2 | -2.00556 |
