| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | hydrochlorothiazide 39.6 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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235 genes differentially expressed following the CRCGN014_HEPG2_3H:P05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 9.85507 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | 5.95652 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | 5.79652 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 5.65414 |
| CSK | c-src tyrosine kinase | 5.32812 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 5.01222 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.90551 |
| STIMATE | STIM activating enhancer | 4.56197 |
| NOTCH1 | notch 1 | 4.42304 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 4.35014 |
| ADRB2 | adrenoceptor beta 2, surface | 4.11803 |
| VGLL4 | vestigial-like family member 4 | 3.96609 |
| MRPS2 | mitochondrial ribosomal protein S2 | 3.86872 |
| CBR3 | carbonyl reductase 3 | 3.75912 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 3.74768 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 3.65057 |
| AMDHD2 | amidohydrolase domain containing 2 | 3.4884 |
| CASC3 | cancer susceptibility candidate 3 | 3.46691 |
| GATA3 | GATA binding protein 3 | 3.39628 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 3.25808 |
| CDK6 | cyclin-dependent kinase 6 | 3.2565 |
| NNT | nicotinamide nucleotide transhydrogenase | 3.15184 |
| TSPAN6 | tetraspanin 6 | 3.02827 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | 2.99659 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 2.98626 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | 2.96392 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 2.9605 |
| SACM1L | SAC1 suppressor of actin mutations 1-like (yeast) | 2.94357 |
| MEST | mesoderm specific transcript | 2.93511 |
| NENF | neudesin neurotrophic factor | 2.91872 |
| MAP7 | microtubule-associated protein 7 | 2.87963 |
| HMG20B | high mobility group 20B | 2.81 |
| PHF2 | PHD finger protein 2 | 2.78807 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 2.75985 |
| MSRA | methionine sulfoxide reductase A | 2.74355 |
| PRKCD | protein kinase C, delta | 2.70395 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 2.69135 |
| CCDC86 | coiled-coil domain containing 86 | 2.67784 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 2.64666 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.6387 |
| SLC39A1 | solute carrier family 39 (zinc transporter), member 1 | 2.62115 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | 2.62004 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.5724 |
| KIF20A | kinesin family member 20A | 2.5589 |
| LOC124907782 | dual specificity protein phosphatase 22 | 2.54255 |
| GADD45G | growth arrest and DNA-damage-inducible, gamma | 2.5393 |
| TCTA | T-cell leukemia translocation altered | 2.53833 |
| UBE3C | ubiquitin protein ligase E3C | 2.52872 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.51089 |
| ZNF146 | zinc finger protein 146 | 2.50066 |
| CDKN2AIP | CDKN2A interacting protein | 2.48224 |
| BTBD3 | BTB (POZ) domain containing 3 | 2.46113 |
| SCARB1 | scavenger receptor class B, member 1 | 2.44019 |
| TRAPPC3 | trafficking protein particle complex 3 | 2.4313 |
| LAG3 | lymphocyte-activation gene 3 | 2.42254 |
| CDK2AP1 | cyclin-dependent kinase 2 associated protein 1 | 2.41122 |
| TCF12 | transcription factor 12 | 2.41013 |
| MOGS | mannosyl-oligosaccharide glucosidase | 2.39719 |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 | 2.38069 |
| PEX11B | peroxisomal biogenesis factor 11 beta | 2.33287 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 2.32931 |
| DEPDC5 | DEP domain containing 5 | 2.31983 |
| P2RX7 | purinergic receptor P2X, ligand gated ion channel, 7 | 2.31941 |
| ELAVL1 | ELAV like RNA binding protein 1 | 2.31588 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.30849 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.29896 |
| SMG9 | SMG9 nonsense mediated mRNA decay factor | 2.29682 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.28416 |
| NUP88 | nucleoporin 88kDa | 2.27977 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 2.27643 |
| ZNF518A | zinc finger protein 518A | 2.26592 |
| TRIM37 | tripartite motif containing 37 | 2.26377 |
| BLCAP | bladder cancer associated protein | 2.23853 |
| NCKIPSD | NCK interacting protein with SH3 domain | 2.23641 |
| TIE1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 2.23256 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.22377 |
| LSP1 | lymphocyte-specific protein 1 | 2.22303 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | 2.2168 |
| CMTR1 | cap methyltransferase 1 | 2.21319 |
| WDR41 | WD repeat domain 41 | 2.20168 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 2.19986 |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | 2.18853 |
| TLK2 | tousled-like kinase 2 | 2.18645 |
| STX11 | syntaxin 11 | 2.16983 |
| ANKRD10 | ankyrin repeat domain 10 | 2.16971 |
| CHEK2 | checkpoint kinase 2 | 2.16292 |
| SPG11 | spastic paraplegia 11 (autosomal recessive) | 2.15331 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.15066 |
| GAST | gastrin | 2.1458 |
| UTRN | utrophin | 2.14389 |
| PYGL | phosphorylase, glycogen, liver | 2.13224 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 2.13174 |
| MED24 | mediator complex subunit 24 | 2.12652 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.1235 |
| KLHDC3 | kelch domain containing 3 | 2.11665 |
| GNRH1 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) | 2.10613 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 2.09906 |
| SYMPK | symplekin | 2.09267 |
| HSPB6 | heat shock protein, alpha-crystallin-related, B6 | 2.09146 |
| NFIL3 | nuclear factor, interleukin 3 regulated | 2.08876 |
| NISCH | nischarin | 2.08723 |
| TMEM80 | transmembrane protein 80 | 2.0842 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 2.08324 |
| NPTN | neuroplastin | 2.06247 |
| U2AF2 | U2 small nuclear RNA auxiliary factor 2 | 2.05934 |
| TNPO1 | transportin 1 | 2.05233 |
| MLEC | malectin | 2.04558 |
| SCAMP2 | secretory carrier membrane protein 2 | 2.04268 |
| WFS1 | Wolfram syndrome 1 (wolframin) | 2.03688 |
| NACA2 | nascent polypeptide-associated complex alpha subunit 2 | 2.03506 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 2.0251 |
| GRAMD4 | GRAM domain containing 4 | 2.02164 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 2.0179 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 2.01452 |
| UVRAG | UV radiation resistance associated | 2.01342 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -9.84008 |
| SCAND1 | SCAN domain containing 1 | -7.93418 |
| RPN1 | ribophorin I | -6.54145 |
| ADI1 | acireductone dioxygenase 1 | -5.61362 |
| ZNF586 | zinc finger protein 586 | -5.23158 |
| LDHD | lactate dehydrogenase D | -4.5918 |
| CCNB2 | cyclin B2 | -4.22996 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -4.15013 |
| CCNH | cyclin H | -4.14628 |
| MAPK13 | mitogen-activated protein kinase 13 | -4.12433 |
| PRCP | prolylcarboxypeptidase (angiotensinase C) | -3.74387 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.69575 |
| TBC1D31 | TBC1 domain family, member 31 | -3.68937 |
| SQOR | sulfide quinone oxidoreductase | -3.66094 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | -3.6319 |
| HSPA8 | heat shock 70kDa protein 8 | -3.62715 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -3.61283 |
| TCTN1 | tectonic family member 1 | -3.55706 |
| CD320 | CD320 molecule | -3.54179 |
| DNM1L | dynamin 1-like | -3.51328 |
| CRYZ | crystallin, zeta (quinone reductase) | -3.49654 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -3.47511 |
| TLCD3A | TLC domain containing 3A | -3.44531 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -3.36924 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -3.32066 |
| CAB39 | calcium binding protein 39 | -3.24438 |
| EIF5 | eukaryotic translation initiation factor 5 | -3.22733 |
| GLB1L2 | galactosidase, beta 1-like 2 | -3.11938 |
| ENOPH1 | enolase-phosphatase 1 | -3.06391 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -3.01599 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -3.00637 |
| HAT1 | histone acetyltransferase 1 | -2.98168 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | -2.93339 |
| SEC61G | Sec61 gamma subunit | -2.8648 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -2.82422 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | -2.82299 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | -2.79649 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.79031 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.73906 |
| EBNA1BP2 | EBNA1 binding protein 2 | -2.71832 |
| SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | -2.71399 |
| HYOU1 | hypoxia up-regulated 1 | -2.71115 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -2.70438 |
| HMGA2 | high mobility group AT-hook 2 | -2.69194 |
| EAPP | E2F-associated phosphoprotein | -2.67684 |
| NGRN | neugrin, neurite outgrowth associated | -2.66158 |
| RXYLT1 | ribitol xylosyltransferase 1 | -2.65359 |
| PRPF4 | pre-mRNA processing factor 4 | -2.64962 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -2.615 |
| NUP93 | nucleoporin 93kDa | -2.61371 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | -2.60794 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -2.60666 |
| MOK | MOK protein kinase | -2.60169 |
| RASL11B | RAS-like, family 11, member B | -2.56936 |
| HADH | hydroxyacyl-CoA dehydrogenase | -2.56769 |
| ZW10 | zw10 kinetochore protein | -2.55053 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -2.54024 |
| RBKS | ribokinase | -2.53175 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -2.52178 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.50418 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -2.46258 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -2.44156 |
| CTSL | cathepsin L | -2.43481 |
| IFRD2 | interferon-related developmental regulator 2 | -2.4187 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | -2.40514 |
| DACT1 | dishevelled-binding antagonist of beta-catenin 1 | -2.40424 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -2.40011 |
| SCN3B | sodium channel, voltage gated, type III beta subunit | -2.39909 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | -2.39319 |
| ZNF358 | zinc finger protein 358 | -2.38846 |
| FAM169A | family with sequence similarity 169, member A | -2.36395 |
| EBLN2 | endogenous Bornavirus-like nucleoprotein 2 | -2.35744 |
| FAIM | Fas apoptotic inhibitory molecule | -2.35362 |
| MUTYH | mutY homolog | -2.35232 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | -2.33547 |
| CLEC11A | C-type lectin domain family 11, member A | -2.332 |
| COPG1 | coatomer protein complex, subunit gamma 1 | -2.32802 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.3231 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.30314 |
| HOMER1 | homer scaffolding protein 1 | -2.28535 |
| HSD17B1 | hydroxysteroid (17-beta) dehydrogenase 1 | -2.27132 |
| ABHD18 | abhydrolase domain containing 18 | -2.26641 |
| DENND10 | DENN domain containing 10 | -2.26474 |
| VAT1 | vesicle amine transport 1 | -2.26062 |
| ISOC1 | isochorismatase domain containing 1 | -2.25294 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -2.24417 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -2.2323 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.23187 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -2.22992 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | -2.22544 |
| CBX3 | chromobox homolog 3 | -2.22167 |
| UBXN8 | UBX domain protein 8 | -2.2181 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | -2.20793 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.20727 |
| TENT2 | terminal nucleotidyltransferase 2 | -2.18992 |
| GOLT1B | golgi transport 1B | -2.17854 |
| SOAT2 | sterol O-acyltransferase 2 | -2.176 |
| EMILIN1 | elastin microfibril interfacer 1 | -2.14784 |
| TAOK1 | TAO kinase 1 | -2.14725 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -2.12877 |
| YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | -2.12588 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | -2.12208 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -2.11423 |
| NPAT | nuclear protein, ataxia-telangiectasia locus | -2.07946 |
| GDAP1 | ganglioside induced differentiation associated protein 1 | -2.07294 |
| WASHC4 | WASH complex subunit 4 | -2.07209 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -2.05753 |
| PNPLA3 | patatin-like phospholipase domain containing 3 | -2.05157 |
| ZBTB44 | zinc finger and BTB domain containing 44 | -2.05122 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -2.05061 |
| MTFR1 | mitochondrial fission regulator 1 | -2.0481 |
| DEFA4 | defensin, alpha 4, corticostatin | -2.04357 |
| SUMF2 | sulfatase modifying factor 2 | -2.04319 |
| ZNF562 | zinc finger protein 562 | -2.03919 |
| USP22 | ubiquitin specific peptidase 22 | -2.0376 |
| TRAPPC4 | trafficking protein particle complex 4 | -2.03488 |
| DPF1 | D4, zinc and double PHD fingers family 1 | -2.02417 |
| PODNL1 | podocan-like 1 | -2.01916 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -2.01318 |
| NTAQ1 | N-terminal glutamine amidase 1 | -2.00066 |
