CRCGN014_HEPG2_3H:P06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isobutyraldehyde 40.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

311 genes differentially expressed following the CRCGN014_HEPG2_3H:P06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 8.02442
NT5DC2 5'-nucleotidase domain containing 2 5.66916
ADRB2 adrenoceptor beta 2, surface 4.72803
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.66537
MYLK myosin light chain kinase 4.66413
NNT nicotinamide nucleotide transhydrogenase 4.64126
NOTCH1 notch 1 4.58625
PRKCH protein kinase C, eta 4.45284
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.32275
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.22783
STK10 serine/threonine kinase 10 4.18968
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 3.93827
PPARG peroxisome proliferator-activated receptor gamma 3.88979
E2F2 E2F transcription factor 2 3.83293
EPHA3 EPH receptor A3 3.82122
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.70014
UBQLN2 ubiquilin 2 3.68915
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.65325
GPATCH8 G patch domain containing 8 3.54933
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.48658
ZNF518A zinc finger protein 518A 3.41464
ADAM10 ADAM metallopeptidase domain 10 3.35303
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.33692
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.32242
MAP7 microtubule-associated protein 7 3.30324
PPIC peptidylprolyl isomerase C (cyclophilin C) 3.25291
PGAM4 phosphoglycerate mutase family member 4 3.21394
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.1842
NENF neudesin neurotrophic factor 3.17325
MELK maternal embryonic leucine zipper kinase 3.15581
MEST mesoderm specific transcript 3.10709
SYNGAP1 synaptic Ras GTPase activating protein 1 3.06926
GALE UDP-galactose-4-epimerase 3.05799
CYCS cytochrome c, somatic 3.03747
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.94305
CA3 carbonic anhydrase III 2.93851
ELP5 elongator acetyltransferase complex subunit 5 2.92023
FAM120C family with sequence similarity 120C 2.91495
CASC3 cancer susceptibility candidate 3 2.84537
TIAM1 T-cell lymphoma invasion and metastasis 1 2.83079
TBX4 T-box 4 2.82021
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.78586
TNNI2 troponin I type 2 (skeletal, fast) 2.77476
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.73298
HMG20B high mobility group 20B 2.71767
JPH2 junctophilin 2 2.68767
TMEM80 transmembrane protein 80 2.68354
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.67401
CCDC86 coiled-coil domain containing 86 2.6716
MRPS2 mitochondrial ribosomal protein S2 2.66753
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.65761
KLHL9 kelch-like family member 9 2.65047
TNNT3 troponin T type 3 (skeletal, fast) 2.64953
CREB1 cAMP responsive element binding protein 1 2.64315
PHKB phosphorylase kinase, beta 2.64107
CSHL1 chorionic somatomammotropin hormone-like 1 2.63432
MYO1F myosin IF 2.63386
PRM2 protamine 2 2.61362
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.60016
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 2.58381
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.58287
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.56569
CCP110 centriolar coiled coil protein 110kDa 2.56435
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.55595
KIFC3 kinesin family member C3 2.55381
SECISBP2 SECIS binding protein 2 2.55262
NFIL3 nuclear factor, interleukin 3 regulated 2.5314
DES desmin 2.52975
IL2RB interleukin 2 receptor, beta 2.50969
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.47972
ARPP19 cAMP-regulated phosphoprotein, 19kDa 2.46401
COG2 component of oligomeric golgi complex 2 2.46321
SCARB1 scavenger receptor class B, member 1 2.46076
HYAL4 hyaluronoglucosaminidase 4 2.45756
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.44757
S1PR5 sphingosine-1-phosphate receptor 5 2.44016
ZNF571 zinc finger protein 571 2.43491
MACROH2A2 macroH2A.2 histone 2.43303
UBE3C ubiquitin protein ligase E3C 2.42948
CCNT2 cyclin T2 2.42336
TMEM267 transmembrane protein 267 2.41775
CD320 CD320 molecule 2.41674
CRTAM cytotoxic and regulatory T cell molecule 2.41555
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.39813
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 2.38649
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.38209
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.36006
SLC49A3 solute carrier family 49 member 3 2.35107
SFTPB surfactant protein B 2.34919
CHRDL1 chordin-like 1 2.34482
SETBP1 SET binding protein 1 2.34148
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.34027
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.33816
H2AB2 H2A.B variant histone 2 2.31924
TBP TATA box binding protein 2.31268
TRAPPC3 trafficking protein particle complex 3 2.29911
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.29395
DAPK1 death-associated protein kinase 1 2.29374
PKN1 protein kinase N1 2.29345
KLHL41 kelch-like family member 41 2.28994
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.28982
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.28919
ZBTB18 zinc finger and BTB domain containing 18 2.28385
KMT5B lysine methyltransferase 5B 2.27939
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.27407
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.27143
DUSP14 dual specificity phosphatase 14 2.26967
MYL11 myosin light chain 11 2.26562
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.26292
CKM creatine kinase, muscle 2.2626
UBXN6 UBX domain protein 6 2.26201
TRAPPC11 trafficking protein particle complex 11 2.25578
MBNL3 muscleblind-like splicing regulator 3 2.24742
GMEB1 glucocorticoid modulatory element binding protein 1 2.24541
PIWIL2 piwi-like RNA-mediated gene silencing 2 2.24228
CDC34 cell division cycle 34 2.24072
TSPAN6 tetraspanin 6 2.23694
YARS1 tyrosyl-tRNA synthetase 1 2.23616
GH1 growth hormone 1 2.23545
HELZ helicase with zinc finger 2.22976
ANKRD10 ankyrin repeat domain 10 2.22721
MTERF3 mitochondrial transcription termination factor 3 2.22719
CYTH3 cytohesin 3 2.22692
ZNF26 zinc finger protein 26 2.22037
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.2191
GPC4 glypican 4 2.21709
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.21514
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.21209
DUSP13A dual specificity phosphatase 13A 2.21137
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 2.21043
TOX3 TOX high mobility group box family member 3 2.2085
CALCA calcitonin-related polypeptide alpha 2.20115
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.19631
ARL14 ADP-ribosylation factor-like 14 2.17857
CD160 CD160 molecule 2.17041
HAPSTR1 HUWE1 associated protein modifying stress responses 2.16801
MRPL12 mitochondrial ribosomal protein L12 2.16328
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.15905
PRKCD protein kinase C, delta 2.15844
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 2.15797
PYCR1 pyrroline-5-carboxylate reductase 1 2.1573
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.1509
TNNC2 troponin C type 2 (fast) 2.14803
STX11 syntaxin 11 2.14781
VCX3A variable charge, X-linked 3A 2.14565
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 2.14503
THAP12 THAP domain containing 12 2.1449
PLEKHO2 pleckstrin homology domain containing, family O member 2 2.1429
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.14145
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.13671
CASQ2 calsequestrin 2 (cardiac muscle) 2.13541
PPP1R12B protein phosphatase 1, regulatory subunit 12B 2.13215
TGFB3 transforming growth factor, beta 3 2.13017
FEM1B fem-1 homolog b (C. elegans) 2.12671
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.12311
MYOZ1 myozenin 1 2.12117
ELOA elongin A 2.11972
MECR mitochondrial trans-2-enoyl-CoA reductase 2.11927
MYH2 myosin, heavy chain 2, skeletal muscle, adult 2.11692
BOLA1 bolA family member 1 2.11488
MINDY2 MINDY lysine 48 deubiquitinase 2 2.11143
BSG basigin (Ok blood group) 2.11052
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.10758
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.10697
BLZF1 basic leucine zipper nuclear factor 1 2.10514
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 2.1035
ZNF263 zinc finger protein 263 2.10265
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.10177
RCOR1 REST corepressor 1 2.09896
PRDM1 PR domain containing 1, with ZNF domain 2.09661
ACTA1 actin, alpha 1, skeletal muscle 2.09474
TBX21 T-box 21 2.09037
PNKP polynucleotide kinase 3'-phosphatase 2.08795
CATSPERG catsper channel auxiliary subunit gamma 2.08642
CHERP calcium homeostasis endoplasmic reticulum protein 2.08043
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 2.07856
NTN3 netrin 3 2.07829
CSH2 chorionic somatomammotropin hormone 2 2.07715
RBMXL2 RNA binding motif protein, X-linked-like 2 2.07563
TLX1 T-cell leukemia homeobox 1 2.0754
TXNIP thioredoxin interacting protein 2.07331
ZNF443 zinc finger protein 443 2.07315
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.0689
MAGED1 melanoma antigen family D1 2.0681
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.06701
STK11 serine/threonine kinase 11 2.06683
ARHGAP19 Rho GTPase activating protein 19 2.06446
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.0642
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 2.06409
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.06332
TFE3 transcription factor binding to IGHM enhancer 3 2.06316
TPM3 tropomyosin 3 2.06229
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 2.05856
COL21A1 collagen, type XXI, alpha 1 2.05467
CMTR1 cap methyltransferase 1 2.054
WDR18 WD repeat domain 18 2.05338
IRGC immunity-related GTPase family, cinema 2.05268
GALK1 galactokinase 1 2.05239
TREX2 three prime repair exonuclease 2 2.05232
VLDLR very low density lipoprotein receptor 2.05176
SHB Src homology 2 domain containing adaptor protein B 2.05164
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.05121
CCDC70 coiled-coil domain containing 70 2.04697
TSSK2 testis-specific serine kinase 2 2.04124
KAT5 K(lysine) acetyltransferase 5 2.04053
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.03776
TMEM260 transmembrane protein 260 2.03426
PYGM phosphorylase, glycogen, muscle 2.03347
S100PBP S100P binding protein 2.03229
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 2.03071
MYBPC1 myosin binding protein C, slow type 2.03005
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.02708
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 2.02701
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.02589
KLRD1 killer cell lectin-like receptor subfamily D, member 1 2.01837
ZNF426 zinc finger protein 426 2.0169
NAT10 N-acetyltransferase 10 (GCN5-related) 2.01409
LGALSL lectin, galactoside-binding-like 2.01283
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.01069
TBX19 T-box 19 2.00718
CA14 carbonic anhydrase XIV 2.00594
OLAH oleoyl-ACP hydrolase 2.00259
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.00222
RAB3B RAB3B, member RAS oncogene family 2.00202

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -7.28664
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.448
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -5.33067
SCAND1 SCAN domain containing 1 -5.03984
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.99704
LDHD lactate dehydrogenase D -4.4772
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.19616
CCNH cyclin H -4.08412
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -4.07791
PCNA proliferating cell nuclear antigen -3.84252
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.83129
CAB39 calcium binding protein 39 -3.81654
GNAS GNAS complex locus -3.72103
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -3.5534
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.33996
PRCP prolylcarboxypeptidase (angiotensinase C) -3.30059
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -3.23851
CCNB1 cyclin B1 -3.13885
MTFR1 mitochondrial fission regulator 1 -3.12616
SLC35F2 solute carrier family 35, member F2 -3.12318
HYOU1 hypoxia up-regulated 1 -3.00974
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.00394
CRYZ crystallin, zeta (quinone reductase) -2.93441
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.93022
EAPP E2F-associated phosphoprotein -2.87667
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.83701
FAIM Fas apoptotic inhibitory molecule -2.73365
RFC2 replication factor C (activator 1) 2, 40kDa -2.69459
NUP93 nucleoporin 93kDa -2.68248
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.59659
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.55701
DYNLT3 dynein, light chain, Tctex-type 3 -2.55156
ACAA1 acetyl-CoA acyltransferase 1 -2.54604
CIB1 calcium and integrin binding 1 (calmyrin) -2.53677
PRPF4 pre-mRNA processing factor 4 -2.49717
HOXC4 homeobox C4 -2.48593
TBPL1 TBP-like 1 -2.48554
FOS FBJ murine osteosarcoma viral oncogene homolog -2.45672
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.44912
THAP11 THAP domain containing 11 -2.43465
PGLS 6-phosphogluconolactonase -2.42787
RTCA RNA 3'-terminal phosphate cyclase -2.41666
VAT1 vesicle amine transport 1 -2.40029
ZW10 zw10 kinetochore protein -2.3769
MOK MOK protein kinase -2.36917
ZZZ3 zinc finger, ZZ-type containing 3 -2.35562
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.35158
SQOR sulfide quinone oxidoreductase -2.32405
HAT1 histone acetyltransferase 1 -2.32303
QARS1 glutaminyl-tRNA synthetase 1 -2.29646
OCEL1 occludin/ELL domain containing 1 -2.27703
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.27299
LAGE3 L antigen family, member 3 -2.27085
MT1F metallothionein 1F -2.24551
MAT2A methionine adenosyltransferase II, alpha -2.23841
CEMIP cell migration inducing protein, hyaluronan binding -2.21398
KIFBP kinesin family binding protein -2.21108
NSG2 neuronal vesicle trafficking associated 2 -2.20138
SGK1 serum/glucocorticoid regulated kinase 1 -2.20117
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.18668
PCNP PEST proteolytic signal containing nuclear protein -2.17504
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.1736
ANXA7 annexin A7 -2.1643
PDE4B phosphodiesterase 4B, cAMP-specific -2.15692
CNN2 calponin 2 -2.11746
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -2.10876
LMO2 LIM domain only 2 (rhombotin-like 1) -2.10845
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -2.10376
HYI hydroxypyruvate isomerase (putative) -2.08535
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.06967
CCNC cyclin C -2.06798
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -2.06198
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.05848
TM9SF2 transmembrane 9 superfamily member 2 -2.05739
EVI2A ecotropic viral integration site 2A -2.0556
CHMP6 charged multivesicular body protein 6 -2.05278
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 -2.0502
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.04963
EBNA1BP2 EBNA1 binding protein 2 -2.04368
PPOX protoporphyrinogen oxidase -2.03626
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.03542
ZFAND1 zinc finger, AN1-type domain 1 -2.03005
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -2.02938
RWDD2B RWD domain containing 2B -2.0208
MT1X metallothionein 1X -2.01848
BLMH bleomycin hydrolase -2.01761
CGRRF1 cell growth regulator with ring finger domain 1 -2.00093