| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-(1-naphthyl)ethylenediamine.2hcl 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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104 genes differentially expressed following the CRCGN014_HEPG2_3H:P07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 10.0 |
| DDIT4 | DNA-damage-inducible transcript 4 | 9.58521 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 5.80108 |
| SFTPB | surfactant protein B | 5.16421 |
| CHN1 | chimerin 1 | 4.78837 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 4.22468 |
| MEST | mesoderm specific transcript | 4.17395 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 3.9933 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.8992 |
| ADRB2 | adrenoceptor beta 2, surface | 3.81976 |
| KDM3A | lysine (K)-specific demethylase 3A | 3.76114 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.6654 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.46511 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 3.44904 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.37794 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 3.22786 |
| H2BC12 | H2B clustered histone 12 | 3.14626 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 2.99783 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.94201 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 2.93606 |
| KAT6A | K(lysine) acetyltransferase 6A | 2.81357 |
| HEBP1 | heme binding protein 1 | 2.80968 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 2.74635 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2.73575 |
| LOC122526780 | uncharacterized LOC122526780 | 2.71454 |
| VGLL4 | vestigial-like family member 4 | 2.68349 |
| TRIB3 | tribbles pseudokinase 3 | 2.66778 |
| EVL | Enah/Vasp-like | 2.64611 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.54936 |
| MX1 | MX dynamin-like GTPase 1 | 2.52213 |
| HYOU1 | hypoxia up-regulated 1 | 2.46186 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.37279 |
| FOXF2 | forkhead box F2 | 2.33366 |
| MSMO1 | methylsterol monooxygenase 1 | 2.32183 |
| ZFP36 | ZFP36 ring finger protein | 2.28628 |
| WFS1 | Wolfram syndrome 1 (wolframin) | 2.27172 |
| CIRBP | cold inducible RNA binding protein | 2.2682 |
| HMG20B | high mobility group 20B | 2.26599 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.22339 |
| CCNF | cyclin F | 2.21482 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 2.2097 |
| DLX5 | distal-less homeobox 5 | 2.19893 |
| RALGDS | ral guanine nucleotide dissociation stimulator | 2.14556 |
| PSG2 | pregnancy specific beta-1-glycoprotein 2 | 2.05769 |
| DIO2 | deiodinase, iodothyronine, type II | 2.0402 |
| ATXN2 | ataxin 2 | 2.03638 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 2.03604 |
| ZNF112 | zinc finger protein 112 | 2.02945 |
| HIGD1B | HIG1 hypoxia inducible domain family, member 1B | 2.00326 |
| GPRC5D | G protein-coupled receptor, class C, group 5, member D | 2.00309 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.00045 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -10.0 |
| UBE3C | ubiquitin protein ligase E3C | -7.46334 |
| IER3 | immediate early response 3 | -7.44393 |
| DNM1L | dynamin 1-like | -5.69454 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -5.66476 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -5.39699 |
| CD320 | CD320 molecule | -4.72509 |
| TLR4 | toll-like receptor 4 | -4.11278 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -4.03102 |
| TLCD3A | TLC domain containing 3A | -4.02675 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -3.86559 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.62884 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -3.45641 |
| RXYLT1 | ribitol xylosyltransferase 1 | -3.19077 |
| CDC20 | cell division cycle 20 | -2.97894 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.96432 |
| CD58 | CD58 molecule | -2.7563 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -2.75417 |
| SLC35F2 | solute carrier family 35, member F2 | -2.65838 |
| CAB39 | calcium binding protein 39 | -2.6571 |
| NGRN | neugrin, neurite outgrowth associated | -2.64988 |
| JMJD6 | jumonji domain containing 6 | -2.6217 |
| PLS1 | plastin 1 | -2.48039 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.47975 |
| DUSP6 | dual specificity phosphatase 6 | -2.47897 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.39342 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -2.37909 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.31896 |
| CTPS1 | CTP synthase 1 | -2.31568 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -2.29359 |
| PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | -2.2778 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -2.27095 |
| SLC38A10 | solute carrier family 38, member 10 | -2.26121 |
| FOSL1 | FOS-like antigen 1 | -2.23761 |
| TRAP1 | TNF receptor-associated protein 1 | -2.21524 |
| AGMAT | agmatine ureohydrolase (agmatinase) | -2.1963 |
| ZYX | zyxin | -2.19571 |
| INTS3 | integrator complex subunit 3 | -2.19175 |
| ILK | integrin-linked kinase | -2.18603 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | -2.16965 |
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | -2.15651 |
| CENPS-CORT | CENPS-CORT readthrough | -2.1545 |
| DSCC1 | DNA replication and sister chromatid cohesion 1 | -2.15197 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -2.14787 |
| RAB32 | RAB32, member RAS oncogene family | -2.11482 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.08295 |
| YME1L1 | YME1-like 1 ATPase | -2.07985 |
| ABHD6 | abhydrolase domain containing 6 | -2.07964 |
| TRIB1 | tribbles pseudokinase 1 | -2.06236 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -2.04528 |
| ASL | argininosuccinate lyase | -2.04412 |
| TXNDC9 | thioredoxin domain containing 9 | -2.04287 |
| LACTB2 | lactamase, beta 2 | -2.03266 |
