CRCGN014_HEPG2_3H:P08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nickel (ii) sulfate hexahydrate 19.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

141 genes differentially expressed following the CRCGN014_HEPG2_3H:P08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
PPARG peroxisome proliferator-activated receptor gamma 5.8153
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.70656
ADRB2 adrenoceptor beta 2, surface 5.47658
STK10 serine/threonine kinase 10 5.16568
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.12485
ANO1 anoctamin 1, calcium activated chloride channel 5.04414
TIAM1 T-cell lymphoma invasion and metastasis 1 4.45353
MYLK myosin light chain kinase 4.37922
CYCS cytochrome c, somatic 4.36644
LYN LYN proto-oncogene, Src family tyrosine kinase 3.75
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.67708
HOXA10 homeobox A10 3.65744
SFTPB surfactant protein B 3.56547
CIAO3 cytosolic iron-sulfur assembly component 3 3.23164
SKIC8 SKI8 subunit of superkiller complex 3.06153
KIF14 kinesin family member 14 2.79428
NPFF neuropeptide FF-amide peptide precursor 2.67879
ADNP activity-dependent neuroprotector homeobox 2.67271
GPATCH8 G patch domain containing 8 2.66449
SLC35H1 solute carrier family 35 member H1 2.65859
MEN1 multiple endocrine neoplasia I 2.62782
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.61266
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.56336
DYNLT3 dynein, light chain, Tctex-type 3 2.54226
GSTM5 glutathione S-transferase mu 5 2.51528
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.46597
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.4623
GSTZ1 glutathione S-transferase zeta 1 2.45613
KLHL3 kelch-like family member 3 2.37658
LGALS14 lectin, galactoside-binding, soluble, 14 2.37366
SCUBE2 signal peptide, CUB domain, EGF-like 2 2.3618
YJU2 YJU2 splicing factor homolog 2.36015
DNM1 dynamin 1 2.35918
CCDC177 coiled-coil domain containing 177 2.34234
EPM2AIP1 EPM2A (laforin) interacting protein 1 2.32428
INPP5J inositol polyphosphate-5-phosphatase J 2.32231
BTK Bruton agammaglobulinemia tyrosine kinase 2.31937
TRIM66 tripartite motif containing 66 2.30232
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.29597
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 2.29381
GPR132 G protein-coupled receptor 132 2.29037
S100G S100 calcium binding protein G 2.28518
FSCN2 fascin actin-bundling protein 2, retinal 2.27557
CALB1 calbindin 1, 28kDa 2.26992
ISOC1 isochorismatase domain containing 1 2.26526
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 2.26422
ZNF556 zinc finger protein 556 2.26295
EGF epidermal growth factor 2.26246
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.26096
ENTREP1 endosomal transmembrane epsin interactor 1 2.25162
EPCAM epithelial cell adhesion molecule 2.22354
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa 2.2202
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 2.21668
TLR7 toll-like receptor 7 2.21589
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.20647
VASH2 vasohibin 2 2.20245
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 2.20218
ZFP91 ZFP91 zinc finger protein 2.19981
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.19974
CD180 CD180 molecule 2.19287
IL13 interleukin 13 2.18766
ADPRH ADP-ribosylarginine hydrolase 2.18119
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.16608
LOXL1 lysyl oxidase-like 1 2.15841
ADORA3 adenosine A3 receptor 2.15339
VENTX VENT homeobox 2.15026
TCIM transcriptional and immune response regulator 2.15018
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.14765
ADAMTSL4 ADAMTS-like 4 2.14494
KLHL9 kelch-like family member 9 2.14126
LCAT lecithin-cholesterol acyltransferase 2.1355
TAS2R16 taste receptor, type 2, member 16 2.12642
MCPH1 microcephalin 1 2.12539
LHX2 LIM homeobox 2 2.12514
CNTN6 contactin 6 2.12442
NEUROG3 neurogenin 3 2.12212
ERMP1 endoplasmic reticulum metallopeptidase 1 2.11852
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.11832
PCDHGA9 protocadherin gamma subfamily A, 9 2.11376
BCO1 beta-carotene oxygenase 1 2.09702
SYNGR3 synaptogyrin 3 2.09556
RASL11B RAS-like, family 11, member B 2.09536
DDHD2 DDHD domain containing 2 2.08864
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 2.0695
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.06735
TMEM94 transmembrane protein 94 2.06179
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 2.05039
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 2.04664
FAT2 FAT atypical cadherin 2 2.04278
DLX5 distal-less homeobox 5 2.03708
KIF24 kinesin family member 24 2.0281
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 2.02405
TFCP2L1 transcription factor CP2-like 1 2.02266
PTPRD protein tyrosine phosphatase, receptor type, D 2.01549
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.0139
TCN2 transcobalamin II 2.00997
NANOS3 nanos homolog 3 (Drosophila) 2.00808
CABP5 calcium binding protein 5 2.00274

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -10.0
CDC20 cell division cycle 20 -6.05882
CCNB2 cyclin B2 -4.57644
PCNA proliferating cell nuclear antigen -4.22773
MAPK13 mitogen-activated protein kinase 13 -3.89571
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.85845
ACLY ATP citrate lyase -3.76362
MEA1 male-enhanced antigen 1 -3.19967
MTA1 metastasis associated 1 -2.80468
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.78551
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.68675
PSRC1 proline/serine-rich coiled-coil 1 -2.67305
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.65443
RAP2A RAP2A, member of RAS oncogene family -2.63924
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -2.50806
PGAM4 phosphoglycerate mutase family member 4 -2.47477
LGMN legumain -2.40222
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -2.39679
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -2.39148
WASHC4 WASH complex subunit 4 -2.37667
CSK c-src tyrosine kinase -2.37571
ACOT9 acyl-CoA thioesterase 9 -2.33733
ARID5B AT rich interactive domain 5B (MRF1-like) -2.33555
TPM4 tropomyosin 4 -2.33452
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -2.32016
TEAD3 TEA domain family member 3 -2.29208
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.20591
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -2.20313
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.20113
AMOTL2 angiomotin like 2 -2.19474
APH1A APH1A gamma secretase subunit -2.18866
RND3 Rho family GTPase 3 -2.18282
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.18157
FAM8A1 family with sequence similarity 8, member A1 -2.17076
FXR2 fragile X mental retardation, autosomal homolog 2 -2.12069
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 -2.11764
STAP2 signal transducing adaptor family member 2 -2.10161
SNX6 sorting nexin 6 -2.09562
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.04993
MRPL37 mitochondrial ribosomal protein L37 -2.02922
SLC39A1 solute carrier family 39 (zinc transporter), member 1 -2.02725
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.0234