CRCGN014_HEPG2_3H:P10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dieldrin 40.6 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN014_HEPG2_3H:P10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.78774
PRKCH protein kinase C, eta 4.59701
MAP7 microtubule-associated protein 7 4.56725
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.53531
EVL Enah/Vasp-like 4.44438
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.2252
PMM2 phosphomannomutase 2 3.85473
SFTPB surfactant protein B 3.31375
PPARG peroxisome proliferator-activated receptor gamma 3.02534
CIAO3 cytosolic iron-sulfur assembly component 3 2.91459
STXBP2 syntaxin binding protein 2 2.90405
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.86659
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.86441
LPAR2 lysophosphatidic acid receptor 2 2.79724
CYCS cytochrome c, somatic 2.71808
KIF14 kinesin family member 14 2.66956
MINDY1 MINDY lysine 48 deubiquitinase 1 2.61419
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.34179
PEX11A peroxisomal biogenesis factor 11 alpha 2.32317
SKIC8 SKI8 subunit of superkiller complex 2.21945
ANO10 anoctamin 10 2.0235

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.91627
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.41967
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.12755
LDHD lactate dehydrogenase D -3.85848
VAT1 vesicle amine transport 1 -3.42226
WASHC4 WASH complex subunit 4 -2.97862
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.96843
TLR4 toll-like receptor 4 -2.90009
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.85385
CDC25B cell division cycle 25B -2.81622
EIF5 eukaryotic translation initiation factor 5 -2.69945
ZMIZ1 zinc finger, MIZ-type containing 1 -2.63108
C2CD5 C2 calcium-dependent domain containing 5 -2.59168
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.54568
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.45153
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.43019
ZNF586 zinc finger protein 586 -2.237
NRIP1 nuclear receptor interacting protein 1 -2.16974
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.16311
TRIB3 tribbles pseudokinase 3 -2.10633