CRCGN014_HEPG2_3H:P13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-amino-2,4-dibromoanthraquinone 25.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN014_HEPG2_3H:P13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.24354
STXBP2 syntaxin binding protein 2 4.08339
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.60304
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.35906
PPARG peroxisome proliferator-activated receptor gamma 3.18517
UBQLN2 ubiquilin 2 3.16086
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.14296
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.02748
GSTZ1 glutathione S-transferase zeta 1 3.02682
CSK c-src tyrosine kinase 2.97949
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.85396
VGLL4 vestigial-like family member 4 2.85299
E2F2 E2F transcription factor 2 2.70829
CEP57 centrosomal protein 57kDa 2.66803
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.33587
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.32475
NUP133 nucleoporin 133kDa 2.29712
SSBP2 single-stranded DNA binding protein 2 2.24898
GPATCH8 G patch domain containing 8 2.23351
SFTPB surfactant protein B 2.17587
CARHSP1 calcium regulated heat stable protein 1, 24kDa 2.11353
TESK1 testis-specific kinase 1 2.05328

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.23275
ZNF586 zinc finger protein 586 -5.43689
TLR4 toll-like receptor 4 -5.34265
PRPF4 pre-mRNA processing factor 4 -3.39169
ITGB1BP1 integrin beta 1 binding protein 1 -3.29559
PCNA proliferating cell nuclear antigen -3.16956
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.1015
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.07734
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.86027
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.78999
FBXL12 F-box and leucine-rich repeat protein 12 -2.69538
RFC2 replication factor C (activator 1) 2, 40kDa -2.68024
RAI14 retinoic acid induced 14 -2.64591
GET1 guided entry of tail-anchored proteins factor 1 -2.18605
CCNB2 cyclin B2 -2.1785
EIF5 eukaryotic translation initiation factor 5 -2.14631
C3AR1 complement component 3a receptor 1 -2.12629
SNX11 sorting nexin 11 -2.10659
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.10131
OXA1L oxidase (cytochrome c) assembly 1-like -2.07262
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 -2.06617