CRCGN014_HEPG2_3H:P14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (e)-3h-indol-3-ylidenemethanol 21.2 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN014_HEPG2_3H:P14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 8.60952
SKIC8 SKI8 subunit of superkiller complex 4.66025
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.87296
DYNLT3 dynein, light chain, Tctex-type 3 3.84633
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 3.24244
PRKCH protein kinase C, eta 3.23555
GPER1 G protein-coupled estrogen receptor 1 3.07973
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.02937
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.95733
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.83869
PNKP polynucleotide kinase 3'-phosphatase 2.79674
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.78766
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.66618
AMDHD2 amidohydrolase domain containing 2 2.66132
ATP11B ATPase, class VI, type 11B 2.64687
ANO1 anoctamin 1, calcium activated chloride channel 2.53075
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.47816
SFTPB surfactant protein B 2.36927
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.36873
LOC122526780 uncharacterized LOC122526780 2.36206
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 2.28992
MEGF8 multiple EGF-like-domains 8 2.22727
SORBS1 sorbin and SH3 domain containing 1 2.19002
KIF14 kinesin family member 14 2.14771
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.11396
IREB2 iron-responsive element binding protein 2 2.11002
CBR3 carbonyl reductase 3 2.02766
EYA4 EYA transcriptional coactivator and phosphatase 4 2.02376
SYNGAP1 synaptic Ras GTPase activating protein 1 2.01097

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -5.4151
MAPK13 mitogen-activated protein kinase 13 -5.29295
CDC20 cell division cycle 20 -4.15324
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.99201
GOLT1B golgi transport 1B -3.76341
TLR4 toll-like receptor 4 -3.49938
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.3433
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.29718
TSPAN4 tetraspanin 4 -3.22508
TUBB6 tubulin, beta 6 class V -2.96295
LDHD lactate dehydrogenase D -2.47071
CCDC86 coiled-coil domain containing 86 -2.29763
BPHL biphenyl hydrolase-like (serine hydrolase) -2.29545
PYCR1 pyrroline-5-carboxylate reductase 1 -2.25128
KRT8 keratin 8, type II -2.16594
KRT18 keratin 18, type I -2.14138
NGRN neugrin, neurite outgrowth associated -2.11439
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.11435
KRT19 keratin 19, type I -2.09278
TXNDC9 thioredoxin domain containing 9 -2.02017
SNX10 sorting nexin 10 -2.01335