CRCGN014_HEPG2_3H:P17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tolbutamide 39.8 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

82 genes differentially expressed following the CRCGN014_HEPG2_3H:P17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.43443
C2CD2 C2 calcium-dependent domain containing 2 4.39353
STAP2 signal transducing adaptor family member 2 4.38957
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.82337
PMM2 phosphomannomutase 2 3.76815
AMDHD2 amidohydrolase domain containing 2 3.33713
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.29053
GPATCH8 G patch domain containing 8 3.1225
CCP110 centriolar coiled coil protein 110kDa 3.11838
PRR15L proline rich 15-like 3.09464
ZNF589 zinc finger protein 589 3.00022
MAGEA1 melanoma antigen family A1 2.80028
FTSJ3 FtsJ homolog 3 (E. coli) 2.74477
MYLK myosin light chain kinase 2.61403
MAGEA12 melanoma antigen family A12 2.60867
VGLL4 vestigial-like family member 4 2.60313
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.56405
MNS1 meiosis-specific nuclear structural 1 2.53272
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.52255
AAAS achalasia, adrenocortical insufficiency, alacrimia 2.47554
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.47011
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.46176
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.45389
SSBP2 single-stranded DNA binding protein 2 2.44461
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.42131
CSAG2 CSAG family, member 2 2.41721
KIF20A kinesin family member 20A 2.40493
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 2.4004
ADRB2 adrenoceptor beta 2, surface 2.3702
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.34902
ATP5F1B ATP synthase F1 subunit beta 2.34744
LPAR2 lysophosphatidic acid receptor 2 2.3272
LOC100533997 MAGEA10-MAGEA5 readthrough 2.2335
CHMP6 charged multivesicular body protein 6 2.1832
FAM168B family with sequence similarity 168, member B 2.17845
CST1 cystatin SN 2.16567
CHN1 chimerin 1 2.14547
ELAC2 elaC ribonuclease Z 2 2.14476
ANO1 anoctamin 1, calcium activated chloride channel 2.12226
EFHC1 EF-hand domain (C-terminal) containing 1 2.06751
AGBL2 ATP/GTP binding protein-like 2 2.05869
GLIPR1 GLI pathogenesis-related 1 2.05747
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.03055
ACAD10 acyl-CoA dehydrogenase family, member 10 2.01888
NGLY1 N-glycanase 1 2.01882
MAGEA8 melanoma antigen family A8 2.01123
EPS15 epidermal growth factor receptor pathway substrate 15 2.00848

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.46261
MAPK13 mitogen-activated protein kinase 13 -5.42219
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.95521
CCNB2 cyclin B2 -3.95162
NRIP1 nuclear receptor interacting protein 1 -3.64521
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.3438
MRPS2 mitochondrial ribosomal protein S2 -3.27392
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.2137
SLC35F2 solute carrier family 35, member F2 -3.20039
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.08772
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.01596
VAT1 vesicle amine transport 1 -3.00829
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.98223
PRPF4 pre-mRNA processing factor 4 -2.93701
TSPAN4 tetraspanin 4 -2.82747
NXT1 nuclear transport factor 2-like export factor 1 -2.78343
ZNF586 zinc finger protein 586 -2.60727
TRIB3 tribbles pseudokinase 3 -2.58795
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.57296
SNX11 sorting nexin 11 -2.40893
CD320 CD320 molecule -2.40095
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.36171
SNRPG small nuclear ribonucleoprotein polypeptide G -2.35469
RPIA ribose 5-phosphate isomerase A -2.3258
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.284
SNRPF small nuclear ribonucleoprotein polypeptide F -2.22047
COX7B cytochrome c oxidase subunit VIIb -2.18074
HSPA14 heat shock 70kDa protein 14 -2.15235
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.10307
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) -2.06524
RPL36 ribosomal protein L36 -2.05543
CD48 CD48 molecule -2.05517
ATP5ME ATP synthase membrane subunit e -2.05483
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.0104