CRCGN014_HEPG2_3H:P18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dichlorophenoxyacetic acid 40.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN014_HEPG2_3H:P18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 7.80057
MAP7 microtubule-associated protein 7 5.56263
E2F2 E2F transcription factor 2 5.26903
ADRB2 adrenoceptor beta 2, surface 5.23616
BACE2 beta-site APP-cleaving enzyme 2 5.03596
MYLK myosin light chain kinase 4.94203
NOTCH1 notch 1 4.70471
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.50901
ABHD6 abhydrolase domain containing 6 3.9194
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.65817
EPHB2 EPH receptor B2 3.62654
DYNLT3 dynein, light chain, Tctex-type 3 3.61507
TIAM1 T-cell lymphoma invasion and metastasis 1 3.5306
GPER1 G protein-coupled estrogen receptor 1 3.28765
SATB1 SATB homeobox 1 3.02197
JADE2 jade family PHD finger 2 2.97324
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.75159
ZBTB18 zinc finger and BTB domain containing 18 2.74283
COPS7A COP9 signalosome subunit 7A 2.70442
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.69546
KIF14 kinesin family member 14 2.6432
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.60211
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.59722
PNKP polynucleotide kinase 3'-phosphatase 2.50886
CDK19 cyclin-dependent kinase 19 2.41792
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.35575
CHMP6 charged multivesicular body protein 6 2.25424
SAA2 serum amyloid A2 2.23525
CXCL2 chemokine (C-X-C motif) ligand 2 2.18923
KLK2 kallikrein-related peptidase 2 2.1654
TPD52L1 tumor protein D52-like 1 2.09611
TM9SF3 transmembrane 9 superfamily member 3 2.06082

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.64549
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.34633
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.89463
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.86652
CCNB2 cyclin B2 -4.61438
LDHD lactate dehydrogenase D -4.61059
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.72113
OXA1L oxidase (cytochrome c) assembly 1-like -3.62002
LOC124907782 dual specificity protein phosphatase 22 -3.46555
NVL nuclear VCP-like -3.34212
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.96019
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.73708
VAT1 vesicle amine transport 1 -2.63492
CDC20 cell division cycle 20 -2.6073
GTPBP8 GTP-binding protein 8 (putative) -2.44273
OSTF1 osteoclast stimulating factor 1 -2.40697
NRIP1 nuclear receptor interacting protein 1 -2.39643
PPP1R9A protein phosphatase 1, regulatory subunit 9A -2.39564
MAPK13 mitogen-activated protein kinase 13 -2.3916
RPL38 ribosomal protein L38 -2.36102
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.35232
TLR4 toll-like receptor 4 -2.28812
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.27833
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.27624
RPL35 ribosomal protein L35 -2.26864
RPLP2 ribosomal protein, large, P2 -2.25088
TTC1 tetratricopeptide repeat domain 1 -2.23665
TCTN1 tectonic family member 1 -2.23539
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.22267
RPL19 ribosomal protein L19 -2.1652
CDC25B cell division cycle 25B -2.13453
SSR4 signal sequence receptor, delta -2.13035
GPR20 G protein-coupled receptor 20 -2.1215
AKAP8 A kinase (PRKA) anchor protein 8 -2.11861
ADGRB3 adhesion G protein-coupled receptor B3 -2.11752
REEP5 receptor accessory protein 5 -2.10513
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase -2.09129
PCNA proliferating cell nuclear antigen -2.06707
EIF5 eukaryotic translation initiation factor 5 -2.06593
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.05442
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -2.04587
RABL3 RAB, member of RAS oncogene family-like 3 -2.04397
RPLP1 ribosomal protein, large, P1 -2.04217
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.02628
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.01654
BCAS2 breast carcinoma amplified sequence 2 -2.01619
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.01302