CRCGN014_HEPG2_3H:P23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description withaferin-a 5.0 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

139 genes differentially expressed following the CRCGN014_HEPG2_3H:P23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 7.99232
DDIT4 DNA-damage-inducible transcript 4 7.76755
BAG3 BCL2-associated athanogene 3 7.57255
EGR1 early growth response 1 6.68581
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 6.29075
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 6.00117
LPAR2 lysophosphatidic acid receptor 2 4.71271
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.63962
CDK7 cyclin-dependent kinase 7 4.32057
PLSCR3 phospholipid scramblase 3 4.10604
CNPY3 canopy FGF signaling regulator 3 4.02137
CARMIL1 capping protein regulator and myosin 1 linker 1 3.94195
JMJD6 jumonji domain containing 6 3.71722
VGLL4 vestigial-like family member 4 3.56391
HSPA1B heat shock 70kDa protein 1B 3.54388
PMM2 phosphomannomutase 2 3.40106
HSPA6 heat shock 70kDa protein 6 (HSP70B') 3.32664
FOXO4 forkhead box O4 3.28944
TERF2IP telomeric repeat binding factor 2, interacting protein 3.13587
IER5 immediate early response 5 3.03164
H2BC12 H2B clustered histone 12 3.0048
BLCAP bladder cancer associated protein 2.95353
CIAO3 cytosolic iron-sulfur assembly component 3 2.94649
FOSL1 FOS-like antigen 1 2.9407
FRS2 fibroblast growth factor receptor substrate 2 2.91956
SYNGAP1 synaptic Ras GTPase activating protein 1 2.91062
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.88914
ABHD4 abhydrolase domain containing 4 2.88462
ZFP36 ZFP36 ring finger protein 2.88388
PRPF38B pre-mRNA processing factor 38B 2.83629
ASCC3 activating signal cointegrator 1 complex subunit 3 2.82584
FOXJ3 forkhead box J3 2.78218
MAMLD1 mastermind-like domain containing 1 2.76415
EGF epidermal growth factor 2.71105
HSPA4L heat shock 70kDa protein 4-like 2.69401
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.68032
NKRF NFKB repressing factor 2.67803
IER2 immediate early response 2 2.67561
HMOX1 heme oxygenase 1 2.60417
ANO1 anoctamin 1, calcium activated chloride channel 2.5896
TBPL1 TBP-like 1 2.58451
SNIP1 Smad nuclear interacting protein 1 2.57837
RNMT RNA (guanine-7-) methyltransferase 2.57831
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 2.56878
CGRRF1 cell growth regulator with ring finger domain 1 2.50746
NUP58 nucleoporin 58 2.50714
NCOA3 nuclear receptor coactivator 3 2.50392
KDM5A lysine (K)-specific demethylase 5A 2.50246
C5 complement component 5 2.50092
TES testin LIM domain protein 2.46387
UBA6 ubiquitin-like modifier activating enzyme 6 2.46105
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 2.44293
NCK1 NCK adaptor protein 1 2.44034
CYCS cytochrome c, somatic 2.43583
PARP2 poly (ADP-ribose) polymerase 2 2.42317
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.41645
FCHO1 FCH domain only 1 2.40827
MEST mesoderm specific transcript 2.4003
SUZ12 SUZ12 polycomb repressive complex 2 subunit 2.38566
CHN1 chimerin 1 2.37655
TERT telomerase reverse transcriptase 2.37124
KIF1B kinesin family member 1B 2.3645
TATDN2 TatD DNase domain containing 2 2.32103
PLS1 plastin 1 2.26084
MAP7 microtubule-associated protein 7 2.24568
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.24145
GADD45B growth arrest and DNA-damage-inducible, beta 2.20397
DUSP2 dual specificity phosphatase 2 2.19973
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.16886
GPATCH2L G patch domain containing 2-like 2.14028
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.10959
CCNT1 cyclin T1 2.04386
MELK maternal embryonic leucine zipper kinase 2.04345
EGR3 early growth response 3 2.02055
CBR3 carbonyl reductase 3 2.02033
ULBP2 UL16 binding protein 2 2.01395
PRKCH protein kinase C, eta 2.00562
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.00013

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.86441
CD320 CD320 molecule -6.7995
COG7 component of oligomeric golgi complex 7 -6.571
CCNB2 cyclin B2 -6.38145
ZNF586 zinc finger protein 586 -6.08086
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.3285
GNAS GNAS complex locus -5.23357
MAPK13 mitogen-activated protein kinase 13 -4.8648
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.86127
BPHL biphenyl hydrolase-like (serine hydrolase) -4.74074
FASTKD5 FAST kinase domains 5 -4.59514
ETFB electron-transfer-flavoprotein, beta polypeptide -4.18422
TMEM109 transmembrane protein 109 -4.09903
TRAP1 TNF receptor-associated protein 1 -3.95915
CCDC86 coiled-coil domain containing 86 -3.52425
ARID5B AT rich interactive domain 5B (MRF1-like) -3.49732
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.49274
RPP38 ribonuclease P/MRP 38kDa subunit -3.22612
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.18448
TCEAL4 transcription elongation factor A (SII)-like 4 -3.15898
TLR4 toll-like receptor 4 -2.97396
FGFR4 fibroblast growth factor receptor 4 -2.85952
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.8491
PEG10 paternally expressed 10 -2.83297
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.82847
NRIP1 nuclear receptor interacting protein 1 -2.70352
SLC35F2 solute carrier family 35, member F2 -2.69881
UGDH UDP-glucose 6-dehydrogenase -2.58157
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.54886
OXA1L oxidase (cytochrome c) assembly 1-like -2.45607
GET1 guided entry of tail-anchored proteins factor 1 -2.40025
HAT1 histone acetyltransferase 1 -2.3888
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.37636
CDC20 cell division cycle 20 -2.36319
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -2.35466
PECR peroxisomal trans-2-enoyl-CoA reductase -2.30156
CRELD2 cysteine-rich with EGF-like domains 2 -2.28143
CASQ2 calsequestrin 2 (cardiac muscle) -2.26394
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.24637
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 -2.23827
MYOC myocilin, trabecular meshwork inducible glucocorticoid response -2.17928
SDF2L1 stromal cell-derived factor 2-like 1 -2.17308
FHL2 four and a half LIM domains 2 -2.16574
CD302 CD302 molecule -2.16338
KLHL9 kelch-like family member 9 -2.1549
CXCL14 chemokine (C-X-C motif) ligand 14 -2.15202
FXN frataxin -2.15178
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.14429
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -2.10034
PCOLCE2 procollagen C-endopeptidase enhancer 2 -2.10004
LXN latexin -2.09206
MRPS16 mitochondrial ribosomal protein S16 -2.07236
DCK deoxycytidine kinase -2.06922
HLA-DMA major histocompatibility complex, class II, DM alpha -2.06907
NDN necdin, melanoma antigen (MAGE) family member -2.05999
REPIN1 replication initiator 1 -2.04999
SOAT2 sterol O-acyltransferase 2 -2.03177
NGRN neugrin, neurite outgrowth associated -2.02843
HOXB5 homeobox B5 -2.01759
TCEAL1 transcription elongation factor A (SII)-like 1 -2.01221
ISOC2 isochorismatase domain containing 2 -2.00215