CRCGN014_HEPG2_3H:P24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description withaferin-a 2.5 um perturbation at 3 h in HEPG2 (Carcinogenome)
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Genes

539 genes differentially expressed following the CRCGN014_HEPG2_3H:P24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 10.0
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 10.0
DDIT4 DNA-damage-inducible transcript 4 9.9133
FOSL1 FOS-like antigen 1 8.31355
BAG3 BCL2-associated athanogene 3 7.503
CNPY3 canopy FGF signaling regulator 3 7.2617
HMOX1 heme oxygenase 1 7.2511
CDPF1 cysteine-rich, DPF motif domain containing 1 6.8152
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 6.8071
ABHD4 abhydrolase domain containing 4 6.40655
LPAR2 lysophosphatidic acid receptor 2 6.10765
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.7989
PPARG peroxisome proliferator-activated receptor gamma 5.7556
EGR1 early growth response 1 5.7167
H2BC12 H2B clustered histone 12 5.4042
HSPA1B heat shock 70kDa protein 1B 5.33735
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.3276
AMDHD2 amidohydrolase domain containing 2 5.186
ARFIP2 ADP-ribosylation factor interacting protein 2 4.91145
RNMT RNA (guanine-7-) methyltransferase 4.91035
FRS2 fibroblast growth factor receptor substrate 2 4.75305
TXNRD1 thioredoxin reductase 1 4.71055
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.65765
CBR3 carbonyl reductase 3 4.54885
CXCL2 chemokine (C-X-C motif) ligand 2 4.4765
JUN jun proto-oncogene 4.42347
CHMP6 charged multivesicular body protein 6 4.28465
RGS2 regulator of G-protein signaling 2 4.25135
AARS1 alanyl-tRNA synthetase 1 4.1357
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.0698
FOXJ3 forkhead box J3 4.01425
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.91825
NOTCH1 notch 1 3.89525
TATDN2 TatD DNase domain containing 2 3.806
HOXA10 homeobox A10 3.7881
FOXO4 forkhead box O4 3.73555
JMJD6 jumonji domain containing 6 3.7111
HSPH1 heat shock 105kDa/110kDa protein 1 3.70213
SAA2 serum amyloid A2 3.67863
SERINC1 serine incorporator 1 3.6487
TBP TATA box binding protein 3.56695
CYCS cytochrome c, somatic 3.52775
EVL Enah/Vasp-like 3.4902
BLCAP bladder cancer associated protein 3.4861
TSC22D3 TSC22 domain family, member 3 3.4761
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 3.46045
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.4235
ANO1 anoctamin 1, calcium activated chloride channel 3.34985
MAP7 microtubule-associated protein 7 3.34168
C5 complement component 5 3.2135
CGRRF1 cell growth regulator with ring finger domain 1 3.1982
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.13935
PLSCR3 phospholipid scramblase 3 3.12535
SQSTM1 sequestosome 1 3.1113
LOC124900388 uncharacterized LOC124900388 3.09505
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 3.0932
HSPA6 heat shock 70kDa protein 6 (HSP70B') 3.0846
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.05595
ODR4 odr-4 GPCR localization factor homolog 3.0427
GADD45B growth arrest and DNA-damage-inducible, beta 3.0263
BICRAL BICRA like chromatin remodeling complex associated protein 3.00005
THBS4 thrombospondin 4 2.98575
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 2.9557
SNAP25 synaptosomal-associated protein, 25kDa 2.94618
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 2.92175
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.8841
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.8734
ATF3 activating transcription factor 3 2.8698
TERF2IP telomeric repeat binding factor 2, interacting protein 2.85255
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.84263
CRYAB crystallin, alpha B 2.83405
ZDHHC18 zinc finger, DHHC-type containing 18 2.83205
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.8214
SKAP2 src kinase associated phosphoprotein 2 2.81715
ARID4A AT rich interactive domain 4A (RBP1-like) 2.8168
LOC128125814 uncharacterized LOC128125814 2.69975
MAPK6 mitogen-activated protein kinase 6 2.694
MFAP4 microfibrillar-associated protein 4 2.69375
SUSD6 sushi domain containing 6 2.67695
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.6764
DCP2 decapping mRNA 2 2.64955
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.63735
EAPP E2F-associated phosphoprotein 2.62865
MBNL2 muscleblind-like splicing regulator 2 2.62413
ELL2 elongation factor, RNA polymerase II, 2 2.62345
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 2.62235
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.6168
OGFRL1 opioid growth factor receptor-like 1 2.60935
KLHL21 kelch-like family member 21 2.6029
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.60225
TES testin LIM domain protein 2.60055
PLK3 polo-like kinase 3 2.59545
COLGALT1 collagen beta(1-O)galactosyltransferase 1 2.59065
ROM1 retinal outer segment membrane protein 1 2.562
KDM5A lysine (K)-specific demethylase 5A 2.55505
SYNGAP1 synaptic Ras GTPase activating protein 1 2.5454
RFC2 replication factor C (activator 1) 2, 40kDa 2.53482
GARRE1 granule associated Rac and RHOG effector 1 2.53385
GMIP GEM interacting protein 2.52585
NSUN3 NOP2/Sun domain family, member 3 2.50695
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.50025
IFRD1 interferon-related developmental regulator 1 2.49825
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.4974
KCTD9 potassium channel tetramerization domain containing 9 2.49395
CHD1 chromodomain helicase DNA binding protein 1 2.48835
CDK6 cyclin-dependent kinase 6 2.45485
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2.4427
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 2.43863
SESN1 sestrin 1 2.4283
SMAP1 small ArfGAP 1 2.42365
NUP133 nucleoporin 133kDa 2.4196
FER fer (fps/fes related) tyrosine kinase 2.4189
SNIP1 Smad nuclear interacting protein 1 2.4118
IGF2R insulin-like growth factor 2 receptor 2.40223
PCDHB16 protocadherin beta 16 2.39638
NAV3 neuron navigator 3 2.3924
GTPBP2 GTP binding protein 2 2.3906
THBD thrombomodulin 2.38582
UBR2 ubiquitin protein ligase E3 component n-recognin 2 2.38403
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.37305
CRLF3 cytokine receptor-like factor 3 2.36805
NGF nerve growth factor (beta polypeptide) 2.3657
TSPYL2 TSPY-like 2 2.3355
CCDC85C coiled-coil domain containing 85C 2.3296
FAM53C family with sequence similarity 53, member C 2.32645
PAGE1 P antigen family, member 1 (prostate associated) 2.32195
TPK1 thiamin pyrophosphokinase 1 2.3159
KDM3A lysine (K)-specific demethylase 3A 2.30155
GATAD2A GATA zinc finger domain containing 2A 2.3014
MEGF6 multiple EGF-like-domains 6 2.29185
PHGDH phosphoglycerate dehydrogenase 2.28332
ELOVL6 ELOVL fatty acid elongase 6 2.27775
DUSP14 dual specificity phosphatase 14 2.2776
MYO1F myosin IF 2.2743
TRIB1 tribbles pseudokinase 1 2.27355
CEP192 centrosomal protein 192kDa 2.2637
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.26
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 2.25635
CDC45 cell division cycle 45 2.2558
BTG2 BTG family, member 2 2.25117
LMBRD1 LMBR1 domain containing 1 2.24785
ARB2A ARB2 cotranscriptional regulator A 2.24575
JOSD1 Josephin domain containing 1 2.239
OBP2A odorant binding protein 2A 2.23805
TNRC6B trinucleotide repeat containing 6B 2.23165
SARAF store-operated calcium entry-associated regulatory factor 2.2239
H2BC4 H2B clustered histone 4 2.22306
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.22135
NMD3 NMD3 ribosome export adaptor 2.21815
TCF20 transcription factor 20 (AR1) 2.21365
KRT7 keratin 7, type II 2.20805
PXDC1 PX domain containing 1 2.20675
SUCO SUN domain containing ossification factor 2.2029
C1QA complement component 1, q subcomponent, A chain 2.2021
ADNP2 ADNP homeobox 2 2.1927
REPS1 RALBP1 associated Eps domain containing 1 2.1809
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.17575
DHDDS dehydrodolichyl diphosphate synthase 2.16718
PSAT1 phosphoserine aminotransferase 1 2.16615
RNF11 ring finger protein 11 2.1647
SEPTIN8 septin 8 2.16465
ATF6 activating transcription factor 6 2.1642
STX3 syntaxin 3 2.15943
TMEM135 transmembrane protein 135 2.15745
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.1477
MXD1 MAX dimerization protein 1 2.14765
PWWP3A PWWP domain containing 3A, DNA repair factor 2.14105
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 2.141
GLIPR1 GLI pathogenesis-related 1 2.1408
NOTCH2NLB notch 2 N-terminal like B 2.13545
KLF2 Kruppel-like factor 2 2.13475
USP36 ubiquitin specific peptidase 36 2.12885
DONSON downstream neighbor of SON 2.12325
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 2.12315
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 2.11645
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.11365
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.11
NUP58 nucleoporin 58 2.10965
MTMR6 myotubularin related protein 6 2.1095
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.10777
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 2.1011
MN1 meningioma (disrupted in balanced translocation) 1 2.0978
EPHB6 EPH receptor B6 2.09475
TRIB3 tribbles pseudokinase 3 2.09195
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.0861
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 2.085
TFE3 transcription factor binding to IGHM enhancer 3 2.0841
CDC42SE1 CDC42 small effector 1 2.083
HAPSTR1 HUWE1 associated protein modifying stress responses 2.08075
IST1 increased sodium tolerance 1 homolog (yeast) 2.0767
ZFP36 ZFP36 ring finger protein 2.07595
PRDX4 peroxiredoxin 4 2.07445
LOC124907782 dual specificity protein phosphatase 22 2.06955
SEC24A SEC24 family member A 2.05935
LASP1 LIM and SH3 protein 1 2.0559
NAMPT nicotinamide phosphoribosyltransferase 2.05403
ACOT9 acyl-CoA thioesterase 9 2.0489
TNPO1 transportin 1 2.04382
MEA1 male-enhanced antigen 1 2.04355
HOXA4 homeobox A4 2.0365
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 2.03045
KIAA0232 KIAA0232 2.02965
TXNDC15 thioredoxin domain containing 15 2.02735
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.025
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 2.02015
KXD1 KxDL motif containing 1 2.0143
CAB39 calcium binding protein 39 2.0137
GSTT1 glutathione S-transferase theta 1 2.0132
UGDH UDP-glucose 6-dehydrogenase 2.01105
PARP2 poly (ADP-ribose) polymerase 2 2.01055
GBA1 glucosylceramidase beta 1 2.01045
PLTP phospholipid transfer protein 2.00905
MCOLN1 mucolipin 1 2.0088
NCOA3 nuclear receptor coactivator 3 2.00786
ZNF106 zinc finger protein 106 2.00645
TAOK3 TAO kinase 3 2.0023

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -8.2655
OXA1L oxidase (cytochrome c) assembly 1-like -8.16945
ARID5B AT rich interactive domain 5B (MRF1-like) -8.00205
COG2 component of oligomeric golgi complex 2 -7.85555
BPHL biphenyl hydrolase-like (serine hydrolase) -6.43435
PEG10 paternally expressed 10 -5.68595
CCNB1 cyclin B1 -5.61155
DERA deoxyribose-phosphate aldolase (putative) -5.1684
LDHD lactate dehydrogenase D -4.93115
DNM1L dynamin 1-like -4.8623
CD320 CD320 molecule -4.85005
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.83595
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.77905
COG7 component of oligomeric golgi complex 7 -4.77505
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7278
DPH2 DPH2 homolog (S. cerevisiae) -4.6094
ETFB electron-transfer-flavoprotein, beta polypeptide -4.57405
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -4.5666
TCEAL4 transcription elongation factor A (SII)-like 4 -4.40925
TRIM13 tripartite motif containing 13 -4.24835
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.2251
GRWD1 glutamate-rich WD repeat containing 1 -4.09975
TRAP1 TNF receptor-associated protein 1 -3.8815
TBC1D31 TBC1 domain family, member 31 -3.8552
GNAS GNAS complex locus -3.80854
DCK deoxycytidine kinase -3.7415
RPP38 ribonuclease P/MRP 38kDa subunit -3.66055
SNRPA small nuclear ribonucleoprotein polypeptide A -3.365
SEC14L5 SEC14-like 5 (S. cerevisiae) -3.34285
AHCY adenosylhomocysteinase -3.30535
DEXI Dexi homolog (mouse) -3.27085
NUP85 nucleoporin 85kDa -3.2622
THAP11 THAP domain containing 11 -3.2392
ATG10 autophagy related 10 -3.2192
RNF123 ring finger protein 123 -3.21805
HNRNPF heterogeneous nuclear ribonucleoprotein F -3.2021
FHL2 four and a half LIM domains 2 -3.19365
GET1 guided entry of tail-anchored proteins factor 1 -3.1566
FAIM Fas apoptotic inhibitory molecule -3.15335
ELAC2 elaC ribonuclease Z 2 -3.15265
SLC35F2 solute carrier family 35, member F2 -3.1435
CS citrate synthase -3.12065
MRPS2 mitochondrial ribosomal protein S2 -3.08755
CUEDC1 CUE domain containing 1 -3.0386
MSH6 mutS homolog 6 -3.01238
SNX11 sorting nexin 11 -2.97775
RRH retinal pigment epithelium-derived rhodopsin homolog -2.9573
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.94765
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 -2.93945
ZNF623 zinc finger protein 623 -2.90865
MRPL58 mitochondrial ribosomal protein L58 -2.90625
PDHB pyruvate dehydrogenase (lipoamide) beta -2.9054
FGF9 fibroblast growth factor 9 -2.8787
DNAAF2 dynein, axonemal, assembly factor 2 -2.8676
HPS6 Hermansky-Pudlak syndrome 6 -2.8407
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.8366
APEH acylaminoacyl-peptide hydrolase -2.8355
E2F5 E2F transcription factor 5, p130-binding -2.83015
STOML2 stomatin (EPB72)-like 2 -2.82885
RPIA ribose 5-phosphate isomerase A -2.8051
CLEC1A C-type lectin domain family 1, member A -2.7852
PLCL1 phospholipase C-like 1 -2.7833
SMIM40 small integral membrane protein 40 -2.76405
ISOC1 isochorismatase domain containing 1 -2.75925
NVL nuclear VCP-like -2.7445
PGM1 phosphoglucomutase 1 -2.72965
SUOX sulfite oxidase -2.72925
TERT telomerase reverse transcriptase -2.7284
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.72375
EGF epidermal growth factor -2.7226
STAMBP STAM binding protein -2.7205
PRPF8 pre-mRNA processing factor 8 -2.71325
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.7064
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.70355
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -2.70078
ACOX2 acyl-CoA oxidase 2, branched chain -2.69815
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.69555
MKS1 Meckel syndrome, type 1 -2.68635
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.68635
ANG angiogenin, ribonuclease, RNase A family, 5 -2.68405
RPS6 ribosomal protein S6 -2.67525
RASL11B RAS-like, family 11, member B -2.6733
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 -2.67095
ZNF286A zinc finger protein 286A -2.65325
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 -2.64425
SIRT4 sirtuin 4 -2.6383
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain -2.6199
SREBF1 sterol regulatory element binding transcription factor 1 -2.6184
NENF neudesin neurotrophic factor -2.618
METTL2A methyltransferase like 2A -2.61685
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) -2.6011
CDK4 cyclin-dependent kinase 4 -2.5984
ZMYM3 zinc finger, MYM-type 3 -2.5976
RPS24 ribosomal protein S24 -2.59395
ANTKMT adenine nucleotide translocase lysine methyltransferase -2.59385
ZFP2 ZFP2 zinc finger protein -2.5847
MPST mercaptopyruvate sulfurtransferase -2.5789
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -2.5617
DNAAF5 dynein, axonemal, assembly factor 5 -2.55295
NRTN neurturin -2.5469
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.5469
PLA2G12A phospholipase A2, group XIIA -2.54205
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.5406
TMEM186 transmembrane protein 186 -2.5297
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.52705
REPIN1 replication initiator 1 -2.5246
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.5205
PROS1 protein S (alpha) -2.5109
MRPL33 mitochondrial ribosomal protein L33 -2.50885
MC4R melanocortin 4 receptor -2.50795
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.5055
STX1A syntaxin 1A (brain) -2.49715
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.4943
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa -2.48998
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.487
MRPS7 mitochondrial ribosomal protein S7 -2.48675
ZBED4 zinc finger, BED-type containing 4 -2.48467
A1CF APOBEC1 complementation factor -2.4821
FSD1 fibronectin type III and SPRY domain containing 1 -2.48035
ASB13 ankyrin repeat and SOCS box containing 13 -2.48
COQ9 coenzyme Q9 -2.47365
CAND1 cullin-associated and neddylation-dissociated 1 -2.47172
UBQLN2 ubiquilin 2 -2.47155
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.45913
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) -2.45075
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.4488
THSD4 thrombospondin, type I, domain containing 4 -2.44745
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -2.4435
LRP6 low density lipoprotein receptor-related protein 6 -2.43663
ATRNL1 attractin-like 1 -2.42667
TPST2 tyrosylprotein sulfotransferase 2 -2.42545
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.41915
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.4161
DNAH2 dynein, axonemal, heavy chain 2 -2.4141
PREB prolactin regulatory element binding -2.41365
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase -2.41325
CCDC86 coiled-coil domain containing 86 -2.4103
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 -2.40955
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 -2.40925
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -2.40373
IFNA7 interferon, alpha 7 -2.4007
ZNF180 zinc finger protein 180 -2.3993
TAS2R16 taste receptor, type 2, member 16 -2.38795
ZNF274 zinc finger protein 274 -2.37805
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -2.37727
MLF2 myeloid leukemia factor 2 -2.3751
ESD esterase D -2.36775
ABHD10 abhydrolase domain containing 10 -2.36465
RLN1 relaxin 1 -2.36145
BTBD2 BTB (POZ) domain containing 2 -2.3606
TMEM177 transmembrane protein 177 -2.35655
ECHDC3 enoyl CoA hydratase domain containing 3 -2.3563
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -2.3553
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.3548
ZNF112 zinc finger protein 112 -2.3443
TKT transketolase -2.34238
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.3421
TRIM28 tripartite motif containing 28 -2.3417
EFHD1 EF-hand domain family, member D1 -2.34145
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -2.33843
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -2.33755
FKBP4 FK506 binding protein 4, 59kDa -2.3314
ATP7B ATPase, Cu++ transporting, beta polypeptide -2.3308
PDZRN3 PDZ domain containing ring finger 3 -2.32695
RPL38 ribosomal protein L38 -2.31805
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -2.31525
AICDA activation-induced cytidine deaminase -2.3103
STAP1 signal transducing adaptor family member 1 -2.30595
RUVBL2 RuvB-like AAA ATPase 2 -2.30585
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.30315
PSRC1 proline/serine-rich coiled-coil 1 -2.30105
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -2.2993
PRDX3 peroxiredoxin 3 -2.29772
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.29755
PRMT1 protein arginine methyltransferase 1 -2.2871
HADH hydroxyacyl-CoA dehydrogenase -2.2845
ACTL6A actin-like 6A -2.2806
TUBAL3 tubulin, alpha-like 3 -2.2781
PEX5L peroxisomal biogenesis factor 5-like -2.27685
METTL25B methyltransferase like 25B -2.27615
MRPS27 mitochondrial ribosomal protein S27 -2.2616
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 -2.25765
MAGEF1 melanoma antigen family F1 -2.25515
SCD5 stearoyl-CoA desaturase 5 -2.2546
KIF13A kinesin family member 13A -2.2537
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.2485
RORB RAR-related orphan receptor B -2.2479
AUP1 ancient ubiquitous protein 1 -2.2443
PLA2G1B phospholipase A2, group IB (pancreas) -2.24155
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.238
OR1F1 olfactory receptor, family 1, subfamily F, member 1 -2.2332
PECR peroxisomal trans-2-enoyl-CoA reductase -2.22795
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -2.22705
TCTN3 tectonic family member 3 -2.22585
TBC1D12 TBC1 domain family, member 12 -2.2257
WASF1 WAS protein family, member 1 -2.2215
ADAM21 ADAM metallopeptidase domain 21 -2.2119
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) -2.20993
GEMIN6 gem (nuclear organelle) associated protein 6 -2.20915
SOX12 SRY (sex determining region Y)-box 12 -2.20855
STMN1 stathmin 1 -2.20555
AMOT angiomotin -2.1974
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.1955
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -2.1952
SYT17 synaptotagmin XVII -2.19215
ZNF721 zinc finger protein 721 -2.18965
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.18685
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase -2.17865
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.17755
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.1753
C5AR2 complement component 5a receptor 2 -2.17465
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.1732
TCERG1 transcription elongation regulator 1 -2.1709
NR5A2 nuclear receptor subfamily 5, group A, member 2 -2.16593
PTPN6 protein tyrosine phosphatase, non-receptor type 6 -2.16495
GRB7 growth factor receptor-bound protein 7 -2.1646
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -2.1645
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -2.16192
ARHGAP8 Rho GTPase activating protein 8 -2.1613
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -2.1557
KLHDC2 kelch domain containing 2 -2.1541
SLC26A4 solute carrier family 26 (anion exchanger), member 4 -2.1523
RBMX RNA binding motif protein, X-linked -2.14925
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -2.14545
TMEM214 transmembrane protein 214 -2.1428
MRM3 mitochondrial rRNA methyltransferase 3 -2.14275
PGLYRP4 peptidoglycan recognition protein 4 -2.14115
KDR kinase insert domain receptor -2.13565
CAMK4 calcium/calmodulin-dependent protein kinase IV -2.13445
CRYGB crystallin, gamma B -2.13385
KNOP1 lysine-rich nucleolar protein 1 -2.132
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa -2.13145
PPP1R9A protein phosphatase 1, regulatory subunit 9A -2.13005
ROGDI rogdi homolog (Drosophila) -2.12805
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -2.1271
KIAA0040 KIAA0040 -2.12687
CD200R1 CD200 receptor 1 -2.12615
RNF144A ring finger protein 144A -2.12505
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -2.1241
PHB2 prohibitin 2 -2.1232
NCAPD2 non-SMC condensin I complex, subunit D2 -2.12295
THSD7A thrombospondin, type I, domain containing 7A -2.12227
TEP1 telomerase-associated protein 1 -2.12005
ZNF362 zinc finger protein 362 -2.11065
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I -2.1019
PRPF4 pre-mRNA processing factor 4 -2.09932
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.0984
TMSB15B thymosin beta 15B -2.09825
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.0968
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) -2.09615
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -2.0946
ESRRG estrogen-related receptor gamma -2.09392
CDC20 cell division cycle 20 -2.09315
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.09205
ZNF257 zinc finger protein 257 -2.0915
TMEM164 transmembrane protein 164 -2.09015
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.08995
ZFY zinc finger protein, Y-linked -2.08835
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.08665
PNLIPRP2 pancreatic lipase-related protein 2 -2.08275
BNC2 basonuclin 2 -2.0783
IAPP islet amyloid polypeptide -2.0773
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -2.0763
S100G S100 calcium binding protein G -2.07595
RABL6 RAB, member RAS oncogene family-like 6 -2.0758
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 -2.07075
NKAIN1 Na+/K+ transporting ATPase interacting 1 -2.0672
SOX18 SRY (sex determining region Y)-box 18 -2.0642
IPO13 importin 13 -2.0635
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 -2.0633
SSTR2 somatostatin receptor 2 -2.06292
FAM3C family with sequence similarity 3, member C -2.0623
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 -2.06115
ARMCX1 armadillo repeat containing, X-linked 1 -2.06025
SLC30A4 solute carrier family 30 (zinc transporter), member 4 -2.05835
CSK c-src tyrosine kinase -2.05635
IL2 interleukin 2 -2.0559
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -2.0528
N4BP3 NEDD4 binding protein 3 -2.051
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -2.0508
INTS3 integrator complex subunit 3 -2.05055
FBXO17 F-box protein 17 -2.04715
GEMIN4 gem (nuclear organelle) associated protein 4 -2.04663
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.04255
RNF170 ring finger protein 170 -2.0418
KIF5A kinesin family member 5A -2.04055
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -2.0391
KL klotho -2.03905
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.0386
NCAPD3 non-SMC condensin II complex, subunit D3 -2.0381
AGGF1 angiogenic factor with G patch and FHA domains 1 -2.03682
LAMB1 laminin, beta 1 -2.0366
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.03575
ZNF507 zinc finger protein 507 -2.03225
GPRC5B G protein-coupled receptor, class C, group 5, member B -2.03165
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.0316
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -2.03095
OR1G1 olfactory receptor, family 1, subfamily G, member 1 -2.0298
TJP3 tight junction protein 3 -2.02472
PKP4 plakophilin 4 -2.02469
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -2.0246
ZBTB44 zinc finger and BTB domain containing 44 -2.02325
ISL1 ISL LIM homeobox 1 -2.02305
PARG poly (ADP-ribose) glycohydrolase -2.0215
PDE5A phosphodiesterase 5A, cGMP-specific -2.0213
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.02095
TWF2 twinfilin actin binding protein 2 -2.02035
KIAA0408 KIAA0408 -2.02015
ZNF239 zinc finger protein 239 -2.0172
MRPL35 mitochondrial ribosomal protein L35 -2.01625
ECI1 enoyl-CoA delta isomerase 1 -2.0154
SMAD4 SMAD family member 4 -2.01365
CNKSR3 CNKSR family member 3 -2.0136
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -2.01345
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) -2.0125
CORT cortistatin -2.01215
ZNF33B zinc finger protein 33B -2.0084
ZNF667 zinc finger protein 667 -2.00835
IFNA16 interferon, alpha 16 -2.00685
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -2.00185
TP53I3 tumor protein p53 inducible protein 3 -2.00095
OR7A5 olfactory receptor, family 7, subfamily A, member 5 -2.00005
NSD3 nuclear receptor binding SET domain protein 3 -2.00005