CRCGN015_HEPG2_48H:A09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description potassium 1h-indol-3-yl sulfate 11.59 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

243 genes differentially expressed following the CRCGN015_HEPG2_48H:A09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 6.16705
SQOR sulfide quinone oxidoreductase 5.36156
VAT1 vesicle amine transport 1 4.94064
ANO10 anoctamin 10 4.15038
ZFP36 ZFP36 ring finger protein 4.04145
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.90089
MAMLD1 mastermind-like domain containing 1 3.82534
CEMIP2 cell migration inducing hyaluronidase 2 3.77795
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.75834
RAP1GAP RAP1 GTPase activating protein 3.40393
FHL2 four and a half LIM domains 2 3.31834
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.24266
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 3.2154
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 3.1875
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.08673
HSPA12A heat shock 70kDa protein 12A 2.98715
TP53I3 tumor protein p53 inducible protein 3 2.9865
RSU1 Ras suppressor protein 1 2.95182
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 2.9454
LPL lipoprotein lipase 2.89114
RALB v-ral simian leukemia viral oncogene homolog B 2.86088
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.85564
SMIM40 small integral membrane protein 40 2.81256
WASHC3 WASH complex subunit 3 2.8063
ANXA4 annexin A4 2.80045
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.79234
BMP4 bone morphogenetic protein 4 2.70117
MX1 MX dynamin-like GTPase 1 2.68113
MX2 MX dynamin-like GTPase 2 2.65458
ILK integrin-linked kinase 2.65202
IFI35 interferon-induced protein 35 2.63719
FABP4 fatty acid binding protein 4, adipocyte 2.62547
MVP major vault protein 2.59968
ACOT9 acyl-CoA thioesterase 9 2.59393
SOCS2 suppressor of cytokine signaling 2 2.58541
PDCD6IP programmed cell death 6 interacting protein 2.5809
CRYZ crystallin, zeta (quinone reductase) 2.57871
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.52298
CNPY3 canopy FGF signaling regulator 3 2.51202
ETFA electron-transfer-flavoprotein, alpha polypeptide 2.50942
PLPP1 phospholipid phosphatase 1 2.49876
CDPF1 cysteine-rich, DPF motif domain containing 1 2.49153
TXNRD1 thioredoxin reductase 1 2.47592
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.47237
INPP1 inositol polyphosphate-1-phosphatase 2.4496
ALAS1 5'-aminolevulinate synthase 1 2.44822
ISG15 ISG15 ubiquitin-like modifier 2.43619
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.42847
UGDH UDP-glucose 6-dehydrogenase 2.40197
GCLM glutamate-cysteine ligase, modifier subunit 2.38186
PPA2 pyrophosphatase (inorganic) 2 2.38022
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.36903
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.3588
CIB1 calcium and integrin binding 1 (calmyrin) 2.3552
ETFB electron-transfer-flavoprotein, beta polypeptide 2.35342
EMCN endomucin 2.35254
PPCS phosphopantothenoylcysteine synthetase 2.34697
ACSL5 acyl-CoA synthetase long-chain family member 5 2.33521
RAB11A RAB11A, member RAS oncogene family 2.31391
TM4SF1 transmembrane 4 L six family member 1 2.30867
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.29105
BECN1 beclin 1, autophagy related 2.2689
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.24116
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.24068
TIMP4 TIMP metallopeptidase inhibitor 4 2.23295
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.22589
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.22478
SEC11A SEC11 homolog A (S. cerevisiae) 2.22346
CYTH1 cytohesin 1 2.21933
HMOX1 heme oxygenase 1 2.19611
MMRN2 multimerin 2 2.19323
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.18774
KCTD9 potassium channel tetramerization domain containing 9 2.18576
AOX1 aldehyde oxidase 1 2.17092
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 2.17081
PRKCD protein kinase C, delta 2.15396
AKR1C1 aldo-keto reductase family 1, member C1 2.14859
SRPX sushi-repeat containing protein, X-linked 2.14605
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.14155
EMC7 ER membrane protein complex subunit 7 2.13951
MAPK13 mitogen-activated protein kinase 13 2.13276
FOXF1 forkhead box F1 2.13211
PLS1 plastin 1 2.12892
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.12666
SNX3 sorting nexin 3 2.11686
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 2.11521
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.11158
HABP4 hyaluronan binding protein 4 2.10355
EIF6 eukaryotic translation initiation factor 6 2.09435
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.08913
TNK1 tyrosine kinase, non-receptor, 1 2.08464
AKR1C3 aldo-keto reductase family 1, member C3 2.08033
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.07963
MT1M metallothionein 1M 2.07694
MKKS McKusick-Kaufman syndrome 2.0743
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.06797
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 2.06612
CSNK1G3 casein kinase 1, gamma 3 2.06519
GPX2 glutathione peroxidase 2 2.0477
MYL12B myosin, light chain 12B, regulatory 2.04375
STBD1 starch binding domain 1 2.04286
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.04195
CDA cytidine deaminase 2.02492
FOXA2 forkhead box A2 2.02303
SQSTM1 sequestosome 1 2.02002
NQO1 NAD(P)H dehydrogenase, quinone 1 2.02
BTBD1 BTB (POZ) domain containing 1 2.00517
PLIN1 perilipin 1 2.005
SPINK1 serine peptidase inhibitor, Kazal type 1 2.00125

decreased expression

Symbol Name Standardized Value
COG7 component of oligomeric golgi complex 7 -4.41551
PROM1 prominin 1 -4.02352
CCNB1 cyclin B1 -3.77198
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -3.5541
PDLIM1 PDZ and LIM domain 1 -3.46972
CXADR coxsackie virus and adenovirus receptor -3.37847
KIF4A kinesin family member 4A -3.37198
AURKB aurora kinase B -3.08322
AUNIP aurora kinase A and ninein interacting protein -3.03718
TBC1D31 TBC1 domain family, member 31 -3.02056
NUSAP1 nucleolar and spindle associated protein 1 -2.92641
MPHOSPH8 M-phase phosphoprotein 8 -2.8544
LBR lamin B receptor -2.8392
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -2.78469
BIRC5 baculoviral IAP repeat containing 5 -2.75697
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.74126
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.72807
KIF15 kinesin family member 15 -2.71237
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.68325
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.65788
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.6415
SKI SKI proto-oncogene -2.6266
TRMT5 tRNA methyltransferase 5 -2.62003
POLR1G RNA polymerase I subunit G -2.6164
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.60393
SH2B2 SH2B adaptor protein 2 -2.59234
CCNB2 cyclin B2 -2.58416
CCNA2 cyclin A2 -2.55872
CEP192 centrosomal protein 192kDa -2.53926
STMN1 stathmin 1 -2.50123
CENPE centromere protein E, 312kDa -2.49413
HMGN2 high mobility group nucleosomal binding domain 2 -2.48891
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.46074
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.45216
RFC3 replication factor C (activator 1) 3, 38kDa -2.44988
NT5DC2 5'-nucleotidase domain containing 2 -2.44283
CCDC81 coiled-coil domain containing 81 -2.44142
FOXM1 forkhead box M1 -2.42319
KNOP1 lysine-rich nucleolar protein 1 -2.42232
PLEKHS1 pleckstrin homology domain containing, family S member 1 -2.41895
KLHL22 kelch-like family member 22 -2.39151
RBM28 RNA binding motif protein 28 -2.38766
XPO4 exportin 4 -2.38405
MGMT O-6-methylguanine-DNA methyltransferase -2.38294
KIF20A kinesin family member 20A -2.36439
TOP2A topoisomerase (DNA) II alpha 170kDa -2.35914
MKS1 Meckel syndrome, type 1 -2.35447
POU2F1 POU class 2 homeobox 1 -2.34724
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.34665
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.34017
LMNB1 lamin B1 -2.33634
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.33471
POLR1E polymerase (RNA) I polypeptide E, 53kDa -2.33186
SMC3 structural maintenance of chromosomes 3 -2.32053
NUP155 nucleoporin 155kDa -2.31576
NCAPG2 non-SMC condensin II complex, subunit G2 -2.31165
UBE2O ubiquitin-conjugating enzyme E2O -2.30495
ASF1B anti-silencing function 1B histone chaperone -2.30453
BORA bora, aurora kinase A activator -2.27945
KLHL26 kelch-like family member 26 -2.27285
SRR serine racemase -2.2691
CD19 CD19 molecule -2.26644
TEAD4 TEA domain family member 4 -2.26213
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.26129
HIRA histone cell cycle regulator -2.25195
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -2.24802
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.24799
CD72 CD72 molecule -2.24789
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -2.24452
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -2.24106
EYA2 EYA transcriptional coactivator and phosphatase 2 -2.23689
UBE2C ubiquitin-conjugating enzyme E2C -2.23577
MAST3 microtubule associated serine/threonine kinase 3 -2.22046
MACF1 microtubule-actin crosslinking factor 1 -2.20585
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -2.2048
KIF11 kinesin family member 11 -2.19903
MYBBP1A MYB binding protein (P160) 1a -2.19732
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.19125
CDC45 cell division cycle 45 -2.18078
VCPKMT valosin containing protein lysine (K) methyltransferase -2.17518
CLDN3 claudin 3 -2.17453
E2F1 E2F transcription factor 1 -2.17151
LIAS lipoic acid synthetase -2.1648
H2AZ2 H2A.Z variant histone 2 -2.15682
RRM2 ribonucleotide reductase M2 -2.15642
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.15208
BRCA1 breast cancer 1, early onset -2.14812
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -2.14572
ZNF573 zinc finger protein 573 -2.13955
MSL2 male-specific lethal 2 homolog (Drosophila) -2.13591
LDLRAP1 low density lipoprotein receptor adaptor protein 1 -2.12823
TMEM97 transmembrane protein 97 -2.12445
NYNRIN NYN domain and retroviral integrase containing -2.12257
TPX2 TPX2, microtubule-associated -2.12249
MYH10 myosin, heavy chain 10, non-muscle -2.12198
BCL7A B-cell CLL/lymphoma 7A -2.12037
WDR70 WD repeat domain 70 -2.11241
ABHD11 abhydrolase domain containing 11 -2.11219
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.11196
MMP9 matrix metallopeptidase 9 -2.10735
PLK1 polo-like kinase 1 -2.10325
CINP cyclin-dependent kinase 2 interacting protein -2.10159
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.10116
ZNF26 zinc finger protein 26 -2.09455
RMDN3 regulator of microtubule dynamics 3 -2.08829
PIM2 Pim-2 proto-oncogene, serine/threonine kinase -2.08524
NIPBL Nipped-B homolog (Drosophila) -2.08452
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.08081
SUZ12 SUZ12 polycomb repressive complex 2 subunit -2.08073
MNS1 meiosis-specific nuclear structural 1 -2.08049
TTPAL tocopherol (alpha) transfer protein-like -2.08
HAUS7 HAUS augmin-like complex, subunit 7 -2.07499
MRPS27 mitochondrial ribosomal protein S27 -2.07355
HAT1 histone acetyltransferase 1 -2.06314
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.06181
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor -2.06054
MKI67 marker of proliferation Ki-67 -2.06003
OIP5 Opa interacting protein 5 -2.04284
SETD6 SET domain containing 6 -2.04261
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -2.03733
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.03701
MCM10 minichromosome maintenance complex component 10 -2.02236
NAIP NLR family, apoptosis inhibitory protein -2.02074
NCAPD2 non-SMC condensin I complex, subunit D2 -2.01802
CDK1 cyclin-dependent kinase 1 -2.01744
AUTS2 autism susceptibility candidate 2 -2.01693
CHIC2 cysteine-rich hydrophobic domain 2 -2.0153
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -2.01483
PGM1 phosphoglucomutase 1 -2.01022
MDN1 MDN1, midasin homolog (yeast) -2.00876
CDCA4 cell division cycle associated 4 -2.0085
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.00379
MCM6 minichromosome maintenance complex component 6 -2.00214
RFC2 replication factor C (activator 1) 2, 40kDa -2.00182