CRCGN015_HEPG2_48H:A15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 10.72 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN015_HEPG2_48H:A15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 3.95713
TXNRD1 thioredoxin reductase 1 3.75842
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 3.4084
ABHD4 abhydrolase domain containing 4 3.17761
TRIB1 tribbles pseudokinase 1 2.95361
SQSTM1 sequestosome 1 2.87693
TOMM34 translocase of outer mitochondrial membrane 34 2.87386
ALG3 ALG3, alpha-1,3- mannosyltransferase 2.64433
CTSL cathepsin L 2.59084
INPP1 inositol polyphosphate-1-phosphatase 2.5686
SBNO1 strawberry notch homolog 1 (Drosophila) 2.56563
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.56357
IER3 immediate early response 3 2.55266
PCCB propionyl CoA carboxylase, beta polypeptide 2.53719
TRMT61B tRNA methyltransferase 61B 2.50888
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.49683
UGDH UDP-glucose 6-dehydrogenase 2.45936
WDR12 WD repeat domain 12 2.42855
NSF N-ethylmaleimide-sensitive factor 2.41379
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.40388
KEAP1 kelch-like ECH-associated protein 1 2.38082
RHOF ras homolog family member F (in filopodia) 2.37986
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.37705
TERF2IP telomeric repeat binding factor 2, interacting protein 2.37239
VRK2 vaccinia related kinase 2 2.3403
YY1AP1 YY1 associated protein 1 2.31999
AK6 adenylate kinase 6 2.27948
KLHL21 kelch-like family member 21 2.2668
MRPS22 mitochondrial ribosomal protein S22 2.26619
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.2561
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.21659
BLVRA biliverdin reductase A 2.21039
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.19531
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) 2.18386
COPG1 coatomer protein complex, subunit gamma 1 2.17214
CASC3 cancer susceptibility candidate 3 2.12733
RIOX2 ribosomal oxygenase 2 2.08608
SLC35F2 solute carrier family 35, member F2 2.07751
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.05984
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.04263
TSPAN14 tetraspanin 14 2.03796
GCLM glutamate-cysteine ligase, modifier subunit 2.037
CRYBG3 beta-gamma crystallin domain containing 3 2.02915
TLE3 transducin-like enhancer of split 3 2.02596
AARSD1 alanyl-tRNA synthetase domain containing 1 2.02347
NLRP2B NLR family pyrin domain containing 2B 2.02015
PALS2 protein associated with LIN7 2, MAGUK p55 family member 2.01174
MAPK13 mitogen-activated protein kinase 13 2.00703

decreased expression

Symbol Name Standardized Value
IL17RB interleukin 17 receptor B -3.75726
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.37402
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.06339
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.8946
PRPF4 pre-mRNA processing factor 4 -2.77612
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.72859
TBC1D31 TBC1 domain family, member 31 -2.63072
BPHL biphenyl hydrolase-like (serine hydrolase) -2.51375
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.41945
TF transferrin -2.37332
IGFBP7 insulin-like growth factor binding protein 7 -2.36506
NUSAP1 nucleolar and spindle associated protein 1 -2.26943
CA8 carbonic anhydrase VIII -2.24523
PROZ protein Z, vitamin K-dependent plasma glycoprotein -2.2326
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.23177
CCNB1 cyclin B1 -2.20086
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -2.16933
MKNK1 MAP kinase interacting serine/threonine kinase 1 -2.14975
ALAD aminolevulinate dehydratase -2.14961
RIPPLY3 ripply transcriptional repressor 3 -2.11685
UFM1 ubiquitin-fold modifier 1 -2.09784
CES3 carboxylesterase 3 -2.0719
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.06129
GUSB glucuronidase, beta -2.0592
NEUROD6 neuronal differentiation 6 -2.05371
TMEM212 transmembrane protein 212 -2.04489
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.03128
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.02649