CRCGN015_HEPG2_48H:A24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (4-chloro-2-methylphenoxy)acetic acid 11.84 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN015_HEPG2_48H:A24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.34404
BAD BCL2-associated agonist of cell death 3.30053
GSTM2 glutathione S-transferase mu 2 (muscle) 3.15629
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.82894
FZD7 frizzled class receptor 7 2.77049
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 2.44394
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 2.37547
TIMP2 TIMP metallopeptidase inhibitor 2 2.31785
AGBL5 ATP/GTP binding protein-like 5 2.29587
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.26406
LYRM1 LYR motif containing 1 2.25807
PDGFRL platelet-derived growth factor receptor-like 2.18961
COQ8A coenzyme Q8A 2.15632
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.141
MACROD1 MACRO domain containing 1 2.10082
TLCD3A TLC domain containing 3A 2.09217
TCEA2 transcription elongation factor A (SII), 2 2.0567
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.04977
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 2.0293
CKAP5 cytoskeleton associated protein 5 2.00688
ARHGAP19 Rho GTPase activating protein 19 2.00423
LTC4S leukotriene C4 synthase 2.00359

decreased expression

Symbol Name Standardized Value
CXADR coxsackie virus and adenovirus receptor -4.4755
YME1L1 YME1-like 1 ATPase -4.30893
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.29135
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.92544
BPHL biphenyl hydrolase-like (serine hydrolase) -2.73456
MCC mutated in colorectal cancers -2.71659
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.58061
SIDT1 SID1 transmembrane family, member 1 -2.38443
ELP3 elongator acetyltransferase complex subunit 3 -2.37154
POC1B-GALNT4 POC1B-GALNT4 readthrough -2.37045
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine -2.36763
MPHOSPH8 M-phase phosphoprotein 8 -2.35491
LNPEP leucyl/cystinyl aminopeptidase -2.3518
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -2.34702
SYTL2 synaptotagmin-like 2 -2.33839
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough -2.30183
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.29848
PRR11 proline rich 11 -2.29163
KLF3 Kruppel-like factor 3 (basic) -2.29056
UFM1 ubiquitin-fold modifier 1 -2.27513
ABHD17B abhydrolase domain containing 17B -2.22015
SPRING1 SREBF pathway regulator in golgi 1 -2.21963
PGAM4 phosphoglycerate mutase family member 4 -2.21696
ISOC1 isochorismatase domain containing 1 -2.18836
HP1BP3 heterochromatin protein 1, binding protein 3 -2.17683
RGPD2 RANBP2-like and GRIP domain containing 2 -2.16792
CCNB1 cyclin B1 -2.16697
GDI2 GDP dissociation inhibitor 2 -2.15843
IPP intracisternal A particle-promoted polypeptide -2.14639
DND1 DND microRNA-mediated repression inhibitor 1 -2.14517
COG7 component of oligomeric golgi complex 7 -2.13779
RB1 retinoblastoma 1 -2.13653
TRH thyrotropin-releasing hormone -2.13594
MTPAP mitochondrial poly(A) polymerase -2.13452
SP140L SP140 nuclear body protein-like -2.12387
OR52A1 olfactory receptor, family 52, subfamily A, member 1 -2.11762
WAC WW domain containing adaptor with coiled-coil -2.09497
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -2.08809
WSB1 WD repeat and SOCS box containing 1 -2.07661
ZNF611 zinc finger protein 611 -2.06862
EFR3B EFR3 homolog B (S. cerevisiae) -2.0611
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -2.04606
C18ORF25 chromosome 18 open reading frame 25 -2.04054
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -2.03791
RHOB ras homolog family member B -2.02621
HYAL4 hyaluronoglucosaminidase 4 -2.01673
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -2.01404
ABHD18 abhydrolase domain containing 18 -2.01027
GSTZ1 glutathione S-transferase zeta 1 -2.00278