CRCGN015_HEPG2_48H:B07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid 96.91 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN015_HEPG2_48H:B07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CISD1 CDGSH iron sulfur domain 1 4.53489
SMIM40 small integral membrane protein 40 4.34126
PRR15L proline rich 15-like 3.80609
EPHB2 EPH receptor B2 3.66074
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.49358
VAT1 vesicle amine transport 1 2.91575
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.76787
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.70241
HMOX1 heme oxygenase 1 2.70051
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.6168
TRIP10 thyroid hormone receptor interactor 10 2.57123
MELK maternal embryonic leucine zipper kinase 2.20413
APOO apolipoprotein O 2.20307
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.16487
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.16388
RAB8B RAB8B, member RAS oncogene family 2.10397
PPARG peroxisome proliferator-activated receptor gamma 2.10187
SRPX sushi-repeat containing protein, X-linked 2.02878

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -5.12384
CCNB1 cyclin B1 -4.69463
PROM1 prominin 1 -3.93572
CXADR coxsackie virus and adenovirus receptor -3.49115
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.21169
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.14755
TXNDC9 thioredoxin domain containing 9 -2.98495
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.52792
UNC50 unc-50 homolog (C. elegans) -2.46897
RAB4A RAB4A, member RAS oncogene family -2.42605
VDAC1 voltage-dependent anion channel 1 -2.37518
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -2.35627
PDCL3 phosducin-like 3 -2.33133
RGS7 regulator of G-protein signaling 7 -2.30483
CHST10 carbohydrate sulfotransferase 10 -2.29173
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -2.27297
RGPD2 RANBP2-like and GRIP domain containing 2 -2.22483
TBC1D31 TBC1 domain family, member 31 -2.20294
PLCB4 phospholipase C, beta 4 -2.19814
RTL10 retrotransposon Gag like 10 -2.15662
TRAPPC8 trafficking protein particle complex 8 -2.14843
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.08045
PLXDC2 plexin domain containing 2 -2.073
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -2.06735
RBM41 RNA binding motif protein 41 -2.06134
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -2.04123
PRMT7 protein arginine methyltransferase 7 -2.01389
COL21A1 collagen, type XXI, alpha 1 -2.00524