CRCGN015_HEPG2_48H:B08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid 32.3 um perturbation at 48 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

41 genes differentially expressed following the CRCGN015_HEPG2_48H:B08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.08383
PRKCQ protein kinase C, theta 3.89517
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.61491
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.28232
PRKCH protein kinase C, eta 3.00898
MAP2K5 mitogen-activated protein kinase kinase 5 3.00398
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.79769
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.78717
ZFP36 ZFP36 ring finger protein 2.70646
FZD7 frizzled class receptor 7 2.52593
CRELD2 cysteine-rich with EGF-like domains 2 2.4731
TYRP1 tyrosinase-related protein 1 2.34274
TMEM109 transmembrane protein 109 2.24632
SHBG sex hormone-binding globulin 2.20341
HDAC2 histone deacetylase 2 2.15288
TYR tyrosinase 2.12155
VAT1 vesicle amine transport 1 2.10606
GPR143 G protein-coupled receptor 143 2.10158
ITM2A integral membrane protein 2A 2.09721
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 2.07604
BFSP1 beaded filament structural protein 1, filensin 2.0732
CD34 CD34 molecule 2.06047
RNPS1 RNA binding protein S1, serine-rich domain 2.04324
FHL5 four and a half LIM domains 5 2.03321
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 2.00124

decreased expression

Symbol Name Standardized Value
PUF60 poly-U binding splicing factor 60KDa -4.26429
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.91866
RAI14 retinoic acid induced 14 -3.80864
UFM1 ubiquitin-fold modifier 1 -3.71418
NCBP3 nuclear cap binding subunit 3 -2.40986
FOXC1 forkhead box C1 -2.38988
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.38023
TM9SF3 transmembrane 9 superfamily member 3 -2.32635
MPDU1 mannose-P-dolichol utilization defect 1 -2.23859
LPIN2 lipin 2 -2.21712
TRIT1 tRNA isopentenyltransferase 1 -2.15385
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.04527
SCRIB scribbled planar cell polarity protein -2.03497
BOP1 block of proliferation 1 -2.02931
PDCL3 phosducin-like 3 -2.01972
OPLAH 5-oxoprolinase (ATP-hydrolysing) -2.00684