CRCGN015_HEPG2_48H:B09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid 10.77 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN015_HEPG2_48H:B09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.39678
GRB10 growth factor receptor-bound protein 10 2.86871
GPN1 GPN-loop GTPase 1 2.40345
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.39285
HMOX1 heme oxygenase 1 2.29161
METRN meteorin, glial cell differentiation regulator 2.2844
SIRT3 sirtuin 3 2.21271
GPX7 glutathione peroxidase 7 2.13733
TBCB tubulin folding cofactor B 2.12351
CHMP6 charged multivesicular body protein 6 2.09901
NLRP2B NLR family pyrin domain containing 2B 2.0876
DCTPP1 dCTP pyrophosphatase 1 2.0632
RABEPK Rab9 effector protein with kelch motifs 2.0512
ETFB electron-transfer-flavoprotein, beta polypeptide 2.02192
LAGE3 L antigen family, member 3 2.02064

decreased expression

Symbol Name Standardized Value
CXADR coxsackie virus and adenovirus receptor -5.9139
TM9SF3 transmembrane 9 superfamily member 3 -4.34227
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -3.14442
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.98946
GADD45A growth arrest and DNA-damage-inducible, alpha -2.94708
IGFBP7 insulin-like growth factor binding protein 7 -2.79104
POC1B-GALNT4 POC1B-GALNT4 readthrough -2.29578
R3HCC1L R3H domain and coiled-coil containing 1-like -2.28022
ECD ecdysoneless homolog (Drosophila) -2.25316
OSMR oncostatin M receptor -2.25106
OSBPL10 oxysterol binding protein-like 10 -2.19629
CCDC186 coiled-coil domain containing 186 -2.18758
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -2.16671
AFF4 AF4/FMR2 family, member 4 -2.13667
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -2.13584
SLIT2 slit homolog 2 (Drosophila) -2.13561
CTSD cathepsin D -2.13138
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa -2.11897
LIFR leukemia inhibitory factor receptor alpha -2.11662
CD46 CD46 molecule, complement regulatory protein -2.07413
NUP62CL nucleoporin 62kDa C-terminal like -2.04226
HIPK3 homeodomain interacting protein kinase 3 -2.03412
MT1X metallothionein 1X -2.01257
ZNF780A zinc finger protein 780A -2.01134
LOC128966601 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like -2.00103