CRCGN015_HEPG2_48H:B14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hp163 perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN015_HEPG2_48H:B14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CBR3 carbonyl reductase 3 6.18546
ABHD4 abhydrolase domain containing 4 4.05168
TXNRD1 thioredoxin reductase 1 3.55513
TRAK2 trafficking protein, kinesin binding 2 3.51352
TRIB1 tribbles pseudokinase 1 3.44521
UGDH UDP-glucose 6-dehydrogenase 3.26483
KEAP1 kelch-like ECH-associated protein 1 3.2091
IGHMBP2 immunoglobulin mu binding protein 2 3.05641
GCLM glutamate-cysteine ligase, modifier subunit 2.83447
TATDN2 TatD DNase domain containing 2 2.62495
NQO1 NAD(P)H dehydrogenase, quinone 1 2.45512
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.30251
EBNA1BP2 EBNA1 binding protein 2 2.27742
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.25174
SQSTM1 sequestosome 1 2.18895
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.16487
ERMP1 endoplasmic reticulum metallopeptidase 1 2.13316
TALDO1 transaldolase 1 2.11988
KLHL21 kelch-like family member 21 2.05789
NOP14 NOP14 nucleolar protein 2.046
MFF mitochondrial fission factor 2.02001
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.01259

decreased expression

Symbol Name Standardized Value
MT1X metallothionein 1X -5.46532
CXADR coxsackie virus and adenovirus receptor -4.30875
UFM1 ubiquitin-fold modifier 1 -3.70581
IL17RB interleukin 17 receptor B -2.52584
FOXJ3 forkhead box J3 -2.484
C5 complement component 5 -2.3443
IGFBP7 insulin-like growth factor binding protein 7 -2.33338
CSRP2 cysteine and glycine-rich protein 2 -2.19014
CCDC102B coiled-coil domain containing 102B -2.15252