CRCGN015_HEPG2_48H:B15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hp163 perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN015_HEPG2_48H:B15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.43503
BACE2 beta-site APP-cleaving enzyme 2 3.55328
BAX BCL2-associated X protein 3.43668
CNPY3 canopy FGF signaling regulator 3 3.28012
USP6NL USP6 N-terminal like 3.25101
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.15728
TXNRD1 thioredoxin reductase 1 3.09918
SNX11 sorting nexin 11 3.05381
ABHD4 abhydrolase domain containing 4 3.03423
UGDH UDP-glucose 6-dehydrogenase 2.97249
MAST2 microtubule associated serine/threonine kinase 2 2.73835
PRKCH protein kinase C, eta 2.52598
CCNA1 cyclin A1 2.50348
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.38727
GCLM glutamate-cysteine ligase, modifier subunit 2.3546
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.21384
PTDSS1 phosphatidylserine synthase 1 2.20266
TOB1 transducer of ERBB2, 1 2.18878
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.15937
HLA-DRA major histocompatibility complex, class II, DR alpha 2.15764
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.06254
TRIM16 tripartite motif containing 16 2.00121
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 2.00092

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -3.91759
TSPAN4 tetraspanin 4 -2.83579
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -2.28054
MCUR1 mitochondrial calcium uniporter regulator 1 -2.27923
GBP1 guanylate binding protein 1, interferon-inducible -2.24504
MT1X metallothionein 1X -2.20529
RHOB ras homolog family member B -2.18306
ZNF219 zinc finger protein 219 -2.06507
SALL2 spalt-like transcription factor 2 -2.01623
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 -2.00701