CRCGN015_HEPG2_48H:B22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 104.84 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

494 genes differentially expressed following the CRCGN015_HEPG2_48H:B22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 7.32034
TRIB1 tribbles pseudokinase 1 5.35138
SQSTM1 sequestosome 1 4.02886
VAT1 vesicle amine transport 1 3.85859
USP6NL USP6 N-terminal like 3.85716
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.79182
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 3.76937
YARS1 tyrosyl-tRNA synthetase 1 3.7574
AARS1 alanyl-tRNA synthetase 1 3.74841
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.73994
GARS1 glycyl-tRNA synthetase 1 3.71228
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 3.64522
TXNRD1 thioredoxin reductase 1 3.64144
NARS1 asparaginyl-tRNA synthetase 1 3.59172
ZFP36 ZFP36 ring finger protein 3.54768
DDIT4 DNA-damage-inducible transcript 4 3.52445
MAPK13 mitogen-activated protein kinase 13 3.50231
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.49766
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.44052
CARS1 cysteinyl-tRNA synthetase 1 3.42696
CTSL cathepsin L 3.40403
NANOS3 nanos homolog 3 (Drosophila) 3.38423
FHL2 four and a half LIM domains 2 3.36744
SARS1 seryl-tRNA synthetase 1 3.35601
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 3.33565
IL4R interleukin 4 receptor 3.29513
INPP1 inositol polyphosphate-1-phosphatase 3.23957
GTPBP2 GTP binding protein 2 3.23602
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 3.21887
ACVR1 activin A receptor, type I 3.19405
RAP1GAP RAP1 GTPase activating protein 3.15217
FAM50A family with sequence similarity 50, member A 3.07739
DDRGK1 DDRGK domain containing 1 3.04425
GFPT1 glutamine--fructose-6-phosphate transaminase 1 3.02124
ATF4 activating transcription factor 4 3.01498
FOSL1 FOS-like antigen 1 2.94284
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.93117
NCK2 NCK adaptor protein 2 2.92985
HMOX1 heme oxygenase 1 2.91335
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 2.89823
PRSS3 protease, serine, 3 2.87341
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.86652
BLVRA biliverdin reductase A 2.86424
PANK2 pantothenate kinase 2 2.85624
GRB10 growth factor receptor-bound protein 10 2.84341
IARS1 isoleucyl-tRNA synthetase 1 2.83071
IER3 immediate early response 3 2.81867
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.78375
RRAGD Ras-related GTP binding D 2.74084
TERF2IP telomeric repeat binding factor 2, interacting protein 2.73324
LHFPL2 lipoma HMGIC fusion partner-like 2 2.72768
C5AR1 complement component 5a receptor 1 2.71835
KCMF1 potassium channel modulatory factor 1 2.71534
MNT MAX network transcriptional repressor 2.70909
AXIN1 axin 1 2.7048
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.68575
GDI1 GDP dissociation inhibitor 1 2.65929
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.64453
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.60288
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.59183
CAMTA2 calmodulin binding transcription activator 2 2.58366
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 2.57461
VRK2 vaccinia related kinase 2 2.56242
STBD1 starch binding domain 1 2.53694
SQOR sulfide quinone oxidoreductase 2.53536
HOPX HOP homeobox 2.53489
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 2.52762
NGRN neugrin, neurite outgrowth associated 2.51488
GTF2IRD1 GTF2I repeat domain containing 1 2.49567
LOC128125814 uncharacterized LOC128125814 2.49367
SRFBP1 serum response factor binding protein 1 2.48693
PRKCD protein kinase C, delta 2.48294
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.48126
IFRD1 interferon-related developmental regulator 1 2.47823
EPS8 epidermal growth factor receptor pathway substrate 8 2.47251
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 2.47163
AVEN apoptosis, caspase activation inhibitor 2.47089
WDR13 WD repeat domain 13 2.46768
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.46635
MAP7D1 MAP7 domain containing 1 2.45319
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.45145
PRSS58 protease, serine, 58 2.44893
TARS1 threonyl-tRNA synthetase 1 2.43721
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.40007
CIDEC cell death-inducing DFFA-like effector c 2.39991
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.38337
MKKS McKusick-Kaufman syndrome 2.36615
PPARG peroxisome proliferator-activated receptor gamma 2.36412
BECN1 beclin 1, autophagy related 2.33413
RNF38 ring finger protein 38 2.33369
CLTB clathrin, light chain B 2.33032
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.32628
RTCA RNA 3'-terminal phosphate cyclase 2.31498
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.30483
IL15RA interleukin 15 receptor, alpha 2.30359
ATF3 activating transcription factor 3 2.30122
TMEM147 transmembrane protein 147 2.2975
PHC2 polyhomeotic homolog 2 (Drosophila) 2.29578
LRRC8D leucine rich repeat containing 8 family, member D 2.28567
G0S2 G0/G1 switch 2 2.28058
PRSS2 protease, serine, 2 (trypsin 2) 2.27841
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 2.27654
KLF2 Kruppel-like factor 2 2.27081
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.27026
PPP1R15A protein phosphatase 1, regulatory subunit 15A 2.26971
PYCR1 pyrroline-5-carboxylate reductase 1 2.26532
FASTKD5 FAST kinase domains 5 2.26443
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.25758
UPP1 uridine phosphorylase 1 2.24308
SMAD2 SMAD family member 2 2.24259
TMEM53 transmembrane protein 53 2.23297
MARS1 methionyl-tRNA synthetase 1 2.23155
XPOT exportin, tRNA 2.22835
THBD thrombomodulin 2.2252
MBD1 methyl-CpG binding domain protein 1 2.22388
SLC67A1 solute carrier family 67 member 1 2.21735
MOSPD1 motile sperm domain containing 1 2.21514
LAD1 ladinin 1 2.20664
DUSP5 dual specificity phosphatase 5 2.20369
CSRNP2 cysteine-serine-rich nuclear protein 2 2.18961
USP3 ubiquitin specific peptidase 3 2.18051
PCDHB11 protocadherin beta 11 2.18012
SUCO SUN domain containing ossification factor 2.1794
RMC1 regulator of MON1-CCZ1 2.1714
POGK pogo transposable element with KRAB domain 2.1698
PHGDH phosphoglycerate dehydrogenase 2.16763
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.1671
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.16063
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 2.15095
ITGB5 integrin, beta 5 2.14911
TERF2 telomeric repeat binding factor 2 2.14765
MEOX2 mesenchyme homeobox 2 2.13938
LONP1 lon peptidase 1, mitochondrial 2.13703
YPEL5 yippee-like 5 (Drosophila) 2.13424
DSG2 desmoglein 2 2.12071
MUTYH mutY homolog 2.11811
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.11732
UBAP1 ubiquitin associated protein 1 2.11707
PFKP phosphofructokinase, platelet 2.11619
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 2.11309
GPR143 G protein-coupled receptor 143 2.11287
JOSD1 Josephin domain containing 1 2.11286
NFIL3 nuclear factor, interleukin 3 regulated 2.11281
RAP1GAP2 RAP1 GTPase activating protein 2 2.11095
GHITM growth hormone inducible transmembrane protein 2.10903
TRIP4 thyroid hormone receptor interactor 4 2.0998
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.09915
LRRN2 leucine rich repeat neuronal 2 2.09787
PFDN2 prefoldin subunit 2 2.09787
ECH1 enoyl CoA hydratase 1, peroxisomal 2.09737
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.09567
MMRN2 multimerin 2 2.09359
PGAP6 post-GPI attachment to proteins 6 2.08917
PYGB phosphorylase, glycogen; brain 2.08914
BYSL bystin-like 2.07207
OCLN occludin 2.06852
CLCN7 chloride channel, voltage-sensitive 7 2.06617
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.06597
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.06075
LRRC42 leucine rich repeat containing 42 2.05768
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.05596
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.05303
CRLF2 cytokine receptor-like factor 2 2.05045
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.05001
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 2.04647
CCDC92 coiled-coil domain containing 92 2.04527
PTH2R parathyroid hormone 2 receptor 2.04003
LOC102724428 serine/threonine-protein kinase SIK1 2.03674
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 2.02607
TOMM34 translocase of outer mitochondrial membrane 34 2.02579
DENND4B DENN/MADD domain containing 4B 2.01833
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.01705
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.01325
JUN jun proto-oncogene 2.01228
FABP4 fatty acid binding protein 4, adipocyte 2.00809
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.00586
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 2.00354
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) 2.00306
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 2.00283
LOC102724560 cystathionine beta-synthase 2.00149

decreased expression

Symbol Name Standardized Value
KIF20A kinesin family member 20A -5.68075
PECR peroxisomal trans-2-enoyl-CoA reductase -5.50544
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -5.16165
CCNB1 cyclin B1 -5.04675
BIRC5 baculoviral IAP repeat containing 5 -4.91576
CCNB2 cyclin B2 -4.48872
TOP2A topoisomerase (DNA) II alpha 170kDa -4.44509
ASF1B anti-silencing function 1B histone chaperone -4.26704
CCNA2 cyclin A2 -4.26283
NUSAP1 nucleolar and spindle associated protein 1 -4.22595
KIF11 kinesin family member 11 -4.1413
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -4.09624
KIF4A kinesin family member 4A -4.08139
CDC25C cell division cycle 25C -4.06239
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -4.05374
KIFC1 kinesin family member C1 -4.01507
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.97541
NEK2 NIMA-related kinase 2 -3.95059
AURKB aurora kinase B -3.90401
PTTG1 pituitary tumor-transforming 1 -3.85727
OIP5 Opa interacting protein 5 -3.83128
ADI1 acireductone dioxygenase 1 -3.73262
NCAPG2 non-SMC condensin II complex, subunit G2 -3.715
FEN1 flap structure-specific endonuclease 1 -3.71315
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.6922
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.67319
NUP85 nucleoporin 85kDa -3.60964
TK1 thymidine kinase 1, soluble -3.58615
ZWINT ZW10 interacting kinetochore protein -3.56651
RACGAP1 Rac GTPase activating protein 1 -3.56099
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.53738
TTK TTK protein kinase -3.50629
TM9SF3 transmembrane 9 superfamily member 3 -3.49616
DHFR dihydrofolate reductase -3.48954
LMNB1 lamin B1 -3.47648
CDC20 cell division cycle 20 -3.44977
LBR lamin B receptor -3.4412
KIF15 kinesin family member 15 -3.42121
CDCA3 cell division cycle associated 3 -3.39711
GINS2 GINS complex subunit 2 (Psf2 homolog) -3.39123
ERCC6L excision repair cross-complementation group 6-like -3.37014
HMGN2 high mobility group nucleosomal binding domain 2 -3.36655
ATAD2 ATPase family, AAA domain containing 2 -3.32081
NCAPH non-SMC condensin I complex, subunit H -3.3188
STMN1 stathmin 1 -3.28572
FANCC Fanconi anemia, complementation group C -3.28409
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.27425
RFC3 replication factor C (activator 1) 3, 38kDa -3.24932
NCAPD2 non-SMC condensin I complex, subunit D2 -3.22748
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.20215
TPX2 TPX2, microtubule-associated -3.16163
CDK1 cyclin-dependent kinase 1 -3.14879
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.14635
HIRIP3 HIRA interacting protein 3 -3.14273
PLK1 polo-like kinase 1 -3.12772
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.11554
FOXM1 forkhead box M1 -3.10244
RFC2 replication factor C (activator 1) 2, 40kDa -3.10221
TRIP13 thyroid hormone receptor interactor 13 -3.0937
MKI67 marker of proliferation Ki-67 -3.08191
SPC25 SPC25, NDC80 kinetochore complex component -3.07461
MCM4 minichromosome maintenance complex component 4 -3.07262
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.06949
KIF22 kinesin family member 22 -3.06006
TRMT5 tRNA methyltransferase 5 -3.02467
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -3.02211
RRM1 ribonucleotide reductase M1 -3.01432
HMGB2 high mobility group box 2 -3.00892
C5 complement component 5 -2.99648
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.98529
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.96868
MCM3 minichromosome maintenance complex component 3 -2.96376
ZWILCH zwilch kinetochore protein -2.9613
HMGA2 high mobility group AT-hook 2 -2.96125
MCM5 minichromosome maintenance complex component 5 -2.95804
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.95722
PGAM4 phosphoglycerate mutase family member 4 -2.95141
MCM10 minichromosome maintenance complex component 10 -2.942
DSCC1 DNA replication and sister chromatid cohesion 1 -2.93959
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.93135
VAV3 vav 3 guanine nucleotide exchange factor -2.92603
DDB2 damage-specific DNA binding protein 2, 48kDa -2.9198
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.91546
SCARA3 scavenger receptor class A, member 3 -2.91381
PDLIM1 PDZ and LIM domain 1 -2.90863
FANCI Fanconi anemia, complementation group I -2.9052
RBM4B RNA binding motif protein 4B -2.90259
CDC45 cell division cycle 45 -2.8969
RRM2 ribonucleotide reductase M2 -2.89194
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.87301
COG7 component of oligomeric golgi complex 7 -2.87229
ACSM5 acyl-CoA synthetase medium-chain family member 5 -2.86836
DEPDC1 DEP domain containing 1 -2.85762
SPDL1 spindle apparatus coiled-coil protein 1 -2.8569
PCLAF PCNA clamp associated factor -2.83425
NCAPD3 non-SMC condensin II complex, subunit D3 -2.83036
CKAP2 cytoskeleton associated protein 2 -2.83021
CDCA8 cell division cycle associated 8 -2.815
TF transferrin -2.80806
KIF18A kinesin family member 18A -2.79317
UBE2C ubiquitin-conjugating enzyme E2C -2.78902
MOCS2 molybdenum cofactor synthesis 2 -2.77242
MNS1 meiosis-specific nuclear structural 1 -2.77239
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.75249
CENPA centromere protein A -2.74133
SPAG5 sperm associated antigen 5 -2.74132
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.73824
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -2.73374
CDK2 cyclin-dependent kinase 2 -2.72719
SESN1 sestrin 1 -2.71743
INCENP inner centromere protein antigens 135/155kDa -2.71015
CCDC15 coiled-coil domain containing 15 -2.70856
PM20D1 peptidase M20 domain containing 1 -2.70527
UFM1 ubiquitin-fold modifier 1 -2.70391
CENPI centromere protein I -2.69179
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 -2.6726
H2AZ2 H2A.Z variant histone 2 -2.67189
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.66784
PLK4 polo-like kinase 4 -2.6584
RFC4 replication factor C (activator 1) 4, 37kDa -2.65252
CDC6 cell division cycle 6 -2.6483
RECQL4 RecQ protein-like 4 -2.64645
PIMREG PICALM interacting mitotic regulator -2.62581
COPS7A COP9 signalosome subunit 7A -2.62159
HJURP Holliday junction recognition protein -2.61847
WDR76 WD repeat domain 76 -2.59753
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.59517
AURKA aurora kinase A -2.59025
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.58609
C8A complement component 8, alpha polypeptide -2.58463
ANAPC15 anaphase promoting complex subunit 15 -2.58111
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.5801
NDC80 NDC80 kinetochore complex component -2.57876
CENPM centromere protein M -2.56558
BORA bora, aurora kinase A activator -2.55968
HPR haptoglobin-related protein -2.55889
MCM7 minichromosome maintenance complex component 7 -2.55545
KIF14 kinesin family member 14 -2.55082
HAT1 histone acetyltransferase 1 -2.54146
TMEM14A transmembrane protein 14A -2.53295
CROT carnitine O-octanoyltransferase -2.53281
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -2.52523
YIPF5 Yip1 domain family, member 5 -2.52244
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.51264
MXD3 MAX dimerization protein 3 -2.51237
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.50976
STARD13 StAR-related lipid transfer (START) domain containing 13 -2.50831
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.50778
FAM13B family with sequence similarity 13, member B -2.50747
CDKN3 cyclin-dependent kinase inhibitor 3 -2.50642
DSN1 DSN1, MIS12 kinetochore complex component -2.49449
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.47321
RFXAP regulatory factor X-associated protein -2.47206
MREG melanoregulin -2.46808
CENPE centromere protein E, 312kDa -2.46214
PCYOX1 prenylcysteine oxidase 1 -2.46169
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.45994
BRCA1 breast cancer 1, early onset -2.44242
GTSE1 G-2 and S-phase expressed 1 -2.44117
SHCBP1 SHC SH2-domain binding protein 1 -2.4368
UXT ubiquitously-expressed, prefoldin-like chaperone -2.43557
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.43338
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 -2.41615
PRC1 protein regulator of cytokinesis 1 -2.41422
FAIM Fas apoptotic inhibitory molecule -2.40994
KIF18B kinesin family member 18B -2.40823
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.40003
GTF2A2 general transcription factor IIA, 2, 12kDa -2.39976
RBBP7 retinoblastoma binding protein 7 -2.39652
TMEM209 transmembrane protein 209 -2.39255
TMEM168 transmembrane protein 168 -2.39214
EXO1 exonuclease 1 -2.39088
HOXA5 homeobox A5 -2.38859
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.38314
E2F8 E2F transcription factor 8 -2.38249
TROAP trophinin associated protein -2.38002
WRAP53 WD repeat containing, antisense to TP53 -2.37716
TMEM97 transmembrane protein 97 -2.37424
ZNF248 zinc finger protein 248 -2.36029
ZNHIT1 zinc finger, HIT-type containing 1 -2.35953
IGFALS insulin-like growth factor binding protein, acid labile subunit -2.34418
RPA3 replication protein A3, 14kDa -2.34189
MFAP3 microfibrillar-associated protein 3 -2.33793
PCNA proliferating cell nuclear antigen -2.33714
MSH2 mutS homolog 2 -2.33232
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.32203
ELP5 elongator acetyltransferase complex subunit 5 -2.31409
NUP107 nucleoporin 107kDa -2.31298
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 -2.31262
ALAD aminolevulinate dehydratase -2.30953
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) -2.29918
ZNF384 zinc finger protein 384 -2.29839
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.29616
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -2.28643
MIS18A MIS18 kinetochore protein A -2.27906
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.27813
ADH6 alcohol dehydrogenase 6 (class V) -2.2749
FTCD formimidoyltransferase cyclodeaminase -2.26962
POLR1F RNA polymerase I subunit F -2.26959
DBF4 DBF4 zinc finger -2.2676
HELLS helicase, lymphoid-specific -2.26484
SLC25A40 solute carrier family 25, member 40 -2.26006
NASP nuclear autoantigenic sperm protein (histone-binding) -2.24557
PBK PDZ binding kinase -2.23213
CENPN centromere protein N -2.22085
CPLX3 complexin 3 -2.21891
PRUNE1 prune exopolyphosphatase 1 -2.21368
ETNPPL ethanolamine-phosphate phospho-lyase -2.21339
ATP5MF ATP synthase membrane subunit f -2.21316
BET1 Bet1 golgi vesicular membrane trafficking protein -2.21159
PRPF19 pre-mRNA processing factor 19 -2.21013
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.20694
AKR1D1 aldo-keto reductase family 1, member D1 -2.20686
SMC4 structural maintenance of chromosomes 4 -2.201
HOXB9 homeobox B9 -2.20033
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.19948
CENPS-CORT CENPS-CORT readthrough -2.19933
DERL2 derlin 2 -2.19824
CKAP5 cytoskeleton associated protein 5 -2.1912
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.18505
TTPA tocopherol (alpha) transfer protein -2.18389
ASTN2 astrotactin 2 -2.17941
CFAP69 cilia and flagella associated protein 69 -2.17842
MTARC2 mitochondrial amidoxime reducing component 2 -2.17398
CSRP2 cysteine and glycine-rich protein 2 -2.17058
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.16607
NUP160 nucleoporin 160kDa -2.16571
METTL16 methyltransferase like 16 -2.15747
CHL1 cell adhesion molecule L1-like -2.1545
FBXO3 F-box protein 3 -2.15293
ISOC2 isochorismatase domain containing 2 -2.15089
PAH phenylalanine hydroxylase -2.14905
MSH3 mutS homolog 3 -2.14488
EXPH5 exophilin 5 -2.14324
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -2.14312
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.14295
RBM23 RNA binding motif protein 23 -2.14252
H2AX H2A.X variant histone -2.14171
SLC17A2 solute carrier family 17, member 2 -2.14168
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -2.13363
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) -2.13236
SAC3D1 SAC3 domain containing 1 -2.12633
BBS4 Bardet-Biedl syndrome 4 -2.12589
DNA2 DNA replication helicase/nuclease 2 -2.12527
CNPY3-GNMT CNPY3-GNMT readthrough -2.12095
CHEK2 checkpoint kinase 2 -2.11719
CEP70 centrosomal protein 70kDa -2.11526
CCDC86 coiled-coil domain containing 86 -2.11414
COMMD9 COMM domain containing 9 -2.11217
PCF11 PCF11 cleavage and polyadenylation factor subunit -2.11036
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.10881
SIK2 salt-inducible kinase 2 -2.10319
PARPBP PARP1 binding protein -2.10289
MAP2K6 mitogen-activated protein kinase kinase 6 -2.10277
PDIA3 protein disulfide isomerase family A, member 3 -2.09444
BCL7C B-cell CLL/lymphoma 7C -2.09024
BPHL biphenyl hydrolase-like (serine hydrolase) -2.08923
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 -2.08844
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -2.08733
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.08731
CCL16 chemokine (C-C motif) ligand 16 -2.08691
FASTK Fas-activated serine/threonine kinase -2.0866
NCKIPSD NCK interacting protein with SH3 domain -2.08541
DUT deoxyuridine triphosphatase -2.08381
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) -2.08204
CFHR3 complement factor H-related 3 -2.08191
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.08184
CALCA calcitonin-related polypeptide alpha -2.07752
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.07399
RAB30 RAB30, member RAS oncogene family -2.07377
ANKRD49 ankyrin repeat domain 49 -2.07053
AUNIP aurora kinase A and ninein interacting protein -2.06951
AURKC aurora kinase C -2.06785
GTPBP8 GTP-binding protein 8 (putative) -2.06208
CCNF cyclin F -2.06052
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.06021
ZNF227 zinc finger protein 227 -2.0598
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide -2.05795
NR2F1 nuclear receptor subfamily 2, group F, member 1 -2.05681
MBTPS2 membrane-bound transcription factor peptidase, site 2 -2.05345
CFHR5 complement factor H-related 5 -2.04664
THOP1 thimet oligopeptidase 1 -2.04456
CEP55 centrosomal protein 55kDa -2.04434
HMGB1 high mobility group box 1 -2.04251
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 -2.04174
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -2.04159
VRK1 vaccinia related kinase 1 -2.04082
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.0406
SRP9 signal recognition particle 9kDa -2.03987
TBC1D31 TBC1 domain family, member 31 -2.03837
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -2.03778
NUP62CL nucleoporin 62kDa C-terminal like -2.03484
RBM48 RNA binding motif protein 48 -2.03423
NCAPG non-SMC condensin I complex, subunit G -2.03367
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.0328
BBS7 Bardet-Biedl syndrome 7 -2.03134
ACADL acyl-CoA dehydrogenase, long chain -2.0292
DHRS1 dehydrogenase/reductase (SDR family) member 1 -2.02911
SDF2L1 stromal cell-derived factor 2-like 1 -2.02877
PAK1IP1 PAK1 interacting protein 1 -2.02649
TPMT thiopurine S-methyltransferase -2.02269
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 -2.02069
ERI2 ERI1 exoribonuclease family member 2 -2.01672
PON1 paraoxonase 1 -2.01617
SRSF1 serine/arginine-rich splicing factor 1 -2.01424
ALG12 ALG12, alpha-1,6-mannosyltransferase -2.01422
CES3 carboxylesterase 3 -2.01227
KCNK10 potassium channel, two pore domain subfamily K, member 10 -2.01162
CDC25A cell division cycle 25A -2.01022
PDK2 pyruvate dehydrogenase kinase, isozyme 2 -2.00773
TFAM transcription factor A, mitochondrial -2.00489
HGFAC HGF activator -2.00474
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.00428
DCAF16 DDB1 and CUL4 associated factor 16 -2.00011