CRCGN015_HEPG2_48H:C03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptamine 11.11 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN015_HEPG2_48H:C03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.17836
MINDY1 MINDY lysine 48 deubiquitinase 1 3.46846
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.42341
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 3.33794
ADRB2 adrenoceptor beta 2, surface 3.31493
ANO10 anoctamin 10 3.00911
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.90671
BAD BCL2-associated agonist of cell death 2.90585
COQ8A coenzyme Q8A 2.59238
TLR4 toll-like receptor 4 2.49369
SHMT1 serine hydroxymethyltransferase 1 (soluble) 2.33894
SIX1 SIX homeobox 1 2.23983
SAMHD1 SAM domain and HD domain 1 2.04237
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.0373
SYNM synemin, intermediate filament protein 2.02773
ADIPOR2 adiponectin receptor 2 2.00462

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -3.73139
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.20342
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -3.04077
ZNF274 zinc finger protein 274 -3.01716
FBXO21 F-box protein 21 -2.87407
PUF60 poly-U binding splicing factor 60KDa -2.86851
PROM1 prominin 1 -2.75555
ARID5A AT rich interactive domain 5A (MRF1-like) -2.52523
TM9SF3 transmembrane 9 superfamily member 3 -2.33147
DUSP2 dual specificity phosphatase 2 -2.30507
COL11A1 collagen, type XI, alpha 1 -2.26803
COG2 component of oligomeric golgi complex 2 -2.17494
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -2.10522
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) -2.09931
RAP2A RAP2A, member of RAS oncogene family -2.08652
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.07432
TEX10 testis expressed 10 -2.00642
MMP13 matrix metallopeptidase 13 -2.00119